The Effect of Contrast Medium SonoVue® on the Electric Charge Density of Blood Cells

The effect of contrast medium SonoVue® on the electric charge density of blood cells (erythrocytes and thrombocytes) was measured using a microelectrophoretic method. We examined the effect of adsorbed H+ and OH− ions on the surface charge of erythrocytes or thrombocytes. Surface charge density values were determined from electrophoretic mobility measurements of blood cells performed at various pH levels. The interaction between solution ions and the erythrocyte’s or thrombocyte’s surface was described by a four-component equilibrium model. The agreement between the experimental and theoretical charge variation curves of the erythrocytes and thrombocytes was good at pH 2–9. The deviation observed at a higher pH may be caused by disregarding interactions between the functional groups of blood cells

Zróżnicowanie gęstości tkanki mózgowej w badaniu tomografii komputerowej w ognisku niedokrwienia w odniesieniu do stanu klinicznego u pacjentów w ostrym i podostrym okresie udaru niedokrwiennego mózgu

Background: The detecion of ischaemic brain tissue by a CT depends on degree and time of hypoperfusion. The aim of the present study was to establish interrelation between morphologic changes in CT scans and clinical classification of focal neurological deficit. Material/Methods: We analyzed data from 139 consecutive patients enrolled in a prospective cohort study at Clinic of Neurology University Hospital in Bialystok, at which emergency CT for patients suspected of having acute (>6 h) ischaemic stroke was performed. Next follow up nonenhanced CT scans were obtained between 7 and 10 day after admission. Resultts: In general, the presence of an ischaemic hypodensity in a patient with signs and symptoms of acute stroke signifies irreversible infarction. In hyperacute and acute stage of ischaemic stroke focal decreased attenuation was about 10-20 HU. In subacute stage focal parenchymal hypodensity further decreased to 20-30 HU. Patients with mild neurological deficit and quick recovery had smaller focal areas of infarct with slight density changes compared to larger territory of infarct extent in patients with severe neurologic symptoms. Conclusions: In subacute stage of ischaemic stroke extent of parenchymal changes and degree of hypodensity correlates with stroke severity and may have some prognostic significance