Cooling curves for neutron stars with hadronic matter and quark matter

The thermal evolution of isothermal neutron stars is studied with matter both in the hadronic phase as well as in the mixed phase of hadronic matter and strange quark matter. In our models, the dominant early-stage cooling process is neutrino emission via the direct Urca process. As a consequence, the cooling curves fall too fast compared to observations. However, when superfluidity is included, the cooling of the neutron stars is significantly slowed down. Furthermore, we find that the cooling curves are not very sensitive to the precise details of the mixing between the hadronic phase and the quark phase and also of the pairing that leads to superfluidity.Comment: 19 pages, 25 figure

Revealing the obscured supernova remnant Kes 32 with Chandra

I report here on the analysis and interpretation of a Chandra observation of the supernova remnant Kes 32. Kes 32 is rather weak in X-rays due to a large interstellar absorption, which is found to be ~4E22 cm^-2, larger than previously reported. Spectral analysis indicates that the ionization age of this object is very young, with n_e t ~ 4E9 cm^-3s, and a temperature of kT_e ~ 1 keV. The X-ray emission peaks at a smaller radius than in the radio. The low ionization age suggests that Kes 32 is a young remnant. However, a young age is in contradiction with the relatively large apparent size, which indicates an age of several thousand years, instead of a few hundred years. This problem is discussed in connection with Kes 32's unknown distance and its possible association with the Norma galactic arm.Comment: Accepted for publication in the Astrophysical Journal. 7 pages, 7 figure

Use of cumulative incidence of novel influenza A/H1N1 in foreign travelers to estimate lower bounds on cumulative incidence in Mexico

Background: An accurate estimate of the total number of cases and severity of illness of an emerging infectious disease is required both to define the burden of the epidemic and to determine the severity of disease. When a novel pathogen first appears, affected individuals with severe symptoms are more likely to be diagnosed. Accordingly, the total number of cases will be underestimated and disease severity overestimated. This problem is manifest in the current epidemic of novel influenza A/H1N1. Methods and Results: We used a simple approach to leverage measures of incident influenza A/H1N1 among a relatively small and well observed group of US, UK, Spanish and Canadian travelers who had visited Mexico to estimate the incidence among a much larger and less well surveyed population of Mexican residents. We estimate that a minimum of 113,000 to 375,000 cases of novel influenza A/H1N1 have occurred in Mexicans during the month of April, 2009. Such an estimate serves as a lower bound because it does not account for underreporting of cases in travelers or for nonrandom mixing between Mexican residents and visitors, which together could increase the estimates by more than an order of magnitude. Conclusions: We find that the number of cases in Mexican residents may exceed the number of confirmed cases by two to three orders of magnitude. While the extent of disease spread is greater than previously appreciated, our estimate suggests that severe disease is uncommon since the total number of cases is likely to be much larger than those of confirmed cases

Dusty OB stars in the Small Magellanic Cloud - II: Extragalactic Disks or Examples of the Pleiades Phenomenon?

We use mid-infrared Spitzer spectroscopy and far-infrared Herschel photometry for a sample of twenty main sequence O9--B2 stars in the Small Magellanic Cloud (SMC) with strong 24 micron excesses to investigate the origin of the mid-IR emission. Either debris disks around the stars or illuminated patches of dense interstellar medium (ISM) can cause such mid-IR emission. In a companion paper, Paper I, we use optical spectroscopy to show that it is unlikely for any of these sources to be classical Be stars or Herbig Ae/Be stars. We focus our analysis on debris disks and cirrus hot spots. We find three out of twenty stars to be significantly extended in the mid-IR, establishing them as cirrus hot spots. We then fit the IR spectral energy distributions to determine dust temperatures and masses. We find the dust masses in the SMC stars to be larger than for any known debris disks, although this evidence against the debris disk hypothesis is circumstantial. Finally, we created a local comparison sample of bright mid-IR OB stars in the Milky Way (MW) by cross-matching the WISE and Hipparcos catalogs. All such local stars in the appropriate luminosity range that can be unambiguously classified are young stars with optical emission lines or are spatially resolved by WISE with sizes too large to be plausible debris disk candidates. We conclude that the very strong mid-IR flux excesses are most likely explained as cirrus hot spots, although we cannot rigorously rule out that a small fraction of the sample is made up of debris disks or transition disks. We present suggestive evidence that bow-shock heating around runaway stars may be a contributing mechanism to the interstellar emission. These sources, interpreted as cirrus hot spots, offer a new localised probe of diffuse interstellar dust in a low metallicity environment. (Abridged)Comment: Accepted for publication in ApJ, 23 pages, 11 figures, 8 table

Four-strand hamstring graft is stiffer than a tripled semitendinosus graft in anterior cruciate ligament reconstruction: a cadaveric study

Purpose: The aim of this study was to compare the biomechanics of a four-strand hamstring graft with a tripled semitendinosus graft, with and without adjustable extra-cortical button fixation, in a cadaveric model. Methods: Four groups of 10 cadaveric hamstrings were tested: In group A, a tripled semitendinosus graft fixated with two adjustable extra-cortical buttons; in Group B, a four-strand semitendinosus and gracilis graft fixated with an adjustable extra-cortical button and a clamp; in group C, a tripled semitendinosus graft fixated to a steel hook and a clamp; in group D, a four-strand semitendinosus and gracilis graft fixated to a steel hook and a cla

Supersonic water masers in 30 Doradus

We report on extremely high velocity molecular gas, up to -80 km/s relative to the ambient medium, in the giant star-formation complex 30 Doradus in the Large Magellanic Cloud (LMC), as observed in new 22 GHz H2O maser emission spectra obtained with the Mopra radio telescope. The masers may trace the velocities of protostars, and the observed morphology and kinematics indicate that current star formation occurs near the interfaces of colliding stellar-wind blown bubbles. The large space velocities of the protostars and associated gas could result in efficient mixing of the LMC. A similar mechanism in the Milky Way could seed the galactic halo with relatively young stars and gas.Comment: 11 pages plus 1 PS and 1 EPS figure, uses AASTeX preprint style; accepted for publication in Astrophysical Journal Letter

The peculiar cluster HS 327 in the Large Magellanic Cloud: can OH/IR stars and carbon stars be twins?

The obscured OH/IR star IRAS05298-6957 in the LMC was recently noticed to be member of the small double cluster HS 327 that also contains a carbon star (van Loon et al., 1998, A&A 329, 169). Hence they are coeval and have (nearly) the same progenitor mass, which can only be understood if Hot Bottom Burning (HBB) has prevented IRAS05298-6957 from being a carbon star. We present extensive visual and near-IR photometric data for >10^4 stars in and around HS 327, and spectroscopic data for some of the brightest AGB stars amongst these. Colour-magnitude diagrams are used to estimate the age for the cluster and its members, and luminosities are derived for the stars for which spectra have been obtained. The age for IRAS05298-6957 and the carbon star is estimated to be about 200 Myr. This corresponds to a Main-Sequence progenitor mass of about 4.0 M_sun --- the first direct measurement of the lower mass threshold for HBB. This agrees with stellar evolution models that, however, fail to reproduce the low luminosity of the carbon star.Comment: 11 pages (better quality Figs 1b & 9 on request from [email protected]). Accepted for publication in Astronomy and Astrophysics Main Journa

Human genetic determinants of the gut microbiome and their associations with health and disease:a phenome-wide association study

Small-scale studies have suggested a link between the human gut microbiome and highly prevalent diseases. However, the extent to which the human gut microbiome can be considered a determinant of disease and healthy aging remains unknown. We aimed to determine the spectrum of diseases that are linked to the human gut microbiome through the utilization of its genetic determinants as a proxy for its composition. 180 single nucleotide polymorphisms (SNPs) known to influence the human gut microbiome were used to assess the association with health and disease outcomes in 422,417 UK Biobank participants. Potential causal estimates were obtained using a Mendelian randomization (MR) approach. From the total sample analysed (mean age was 57 ± 8 years), 194,567 (46%) subjects were male. Median exposure was 66-person years (interquartile range 59–72). Eleven SNPs were significantly associated with 28 outcomes (Bonferroni corrected P value < 4.63·10−6) including food intake, hypertension, atopy, COPD, BMI, and lipids. Multiple SNP MR pointed to a possible causal link between Ruminococcus flavefaciens and hypertension, and Clostridium and platelet count. Microbiota and their metabolites might be of importance in the interplay between overlapping pathophysiological processes, although challenges remain in establishing causal relationships

Immune checkpoint inhibitor treatment induces colitis with heavy infiltration of CD8+T cells and an infiltration pattern that resembles ulcerative colitis

Colitis is a common, but poorly understood, adverse event of immune checkpoint inhibitors that are standard-of-care for an expanding range of cancer types. This explorative study aimed to describe the immune infiltrates in the colon from individuals developing checkpoint inhibitor colitis and compare them to well-known immunophenotypes of acute graft-versus-host disease, ulcerative colitis, and Crohn’s disease. Colon biopsies (n = 20 per group) of patients with checkpoint inhibitor colitis, acute graft-versus-host disease, ulcerative colitis and Crohn’s disease, all colitis treatment-naïve, and of individuals with a normal colon were analyzed using immunohistochemistry: CD8 for cytotoxic T cells, CD4 for T helper cells, and CD68 to identify cells of macrophage lineage. CD8 + T cell, CD4 + T cell, and CD68 + cell counts were performed. Cell infiltration was scored as scattered/patchy or band-like in the superficial and deep gut mucosa. Checkpoint inhibitor colitis was found to be heavily infiltrated by CD8 + T cells. Comparative analysis between groups showed that both CD8 + T cell counts (P < 0.01) and immune cell infiltration patterns in checkpoint inhibitor colitis were most similar to those observed in ulcerative colitis, with a deep band-like CD4 + T cell infiltration pattern and a superficial band-like CD68 + cell infiltration pattern in both. In conclusion, this is the first immunohistopathological study comparing infiltrate characteristics of checkpoint inhibitor colitis, acute graft-versus-host disease, ulcerative colitis, and Crohn’s disease. Checkpoint inhibitor colitis samples are heterogeneous, heavily infiltrated by CD8 + T cells, and show an immune cell infiltration pattern that is more similar to ulcerative colitis than to colonic acute graft-versus-host disease or colonic Crohn’s disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00428-021-03170-x