The conceptual structure of the HERQL.

<p>Circles: latent factors, rectangles: measured variables (questionnaire items). Q01: pain at rest, Q02: hernia protrusion, Q03: pain from mild activity, Q04: pain from moderate activity, Q05: pain from heavy activity, Q08: analgesic usage, Q09: activity restriction, Q11: hernia’s impact on health, Q12: economic burden, Q13: quality of life/global health. Arrows indicate the direction of regressive relationships. Numeric values are regression weights. *P<0.05, **P<0.01.</p

Distributions of the HERQL scores with Likert’s type scales in the field study (n = 386).

<p>Distributions of the HERQL scores with Likert’s type scales in the field study (n = 386).</p

Demographic and clinical features of enrolled patients.

<p>Demographic and clinical features of enrolled patients.</p

Repeated measures of the summative pain scores.

<p>Mean and 95% confidence interval of the summative pain scores are depicted at three time points. Vertical axis: summative pain score, horizontal axis: pre-operative (time = 0), immediately post-operative (time = 1), and post-operative 3-month of interval (time = 3).</p

Known-group comparisons of the HERQL.

<p>Known-group comparisons of the HERQL.</p

The conceptual structure of the extended model of the HERQL with the auxiliary post-operative patient satisfaction module.

<p>Circles: latent factors, rectangles: measured variables (questionnaire items). Q01-05, Q08-09, and Q11-13 are the same as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0183138#pone.0183138.g001" target="_blank">Fig 1</a>. Q15: foreign body sensation, Q17: complication severity, Q18: overall satisfaction, Q19: confidence in hernia repair, Q20: quality of life improvement by hernia repair. Arrows indicate the direction of regressive relationships. Numeric values are regression weights. *P<0.05, **P<0.01.</p

Disease-free survival in 408 Han Chinese breast cancer patients stratified by the 16-concurrent gene signature (Log-rank test: <i>P</i> <0.001).

<p>X-axis: survival time in years.</p

Flow chart of study design (GSEA: Gene set enrichment analysis).

<p>Flow chart of study design (GSEA: Gene set enrichment analysis).</p

Disease-free survival in 214 ER-positive Han Chinese breast cancer patients.

<p>(A) Stratified by intrinsic subtypes (proportional hazards assumption violated) and (B) stratified by the 16-concurrent gene signature (Log-rank test: <i>P</i> = 0.023). SSP: single sample prediction, Her2: HER2-enriched, LumA: luminal A, LumB: luminal B subtype breast cancer. X-axis: survival time in years.</p

Frequency plot of copy number variation in a sample of 23 Taiwanese breast cancers.

<p>Frequency plot of copy number variation in a sample of 23 Taiwanese breast cancers.</p