12 research outputs found
Nondestructive testing of contaminated CFRP surfaces with the BonNDTinspect® system
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Defects in the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans.
- Author
- Airik R
- Beales PL
- Bizet AA
- Bole-Feysot C
- Braun DA
- Brown MA
- Burtey S
- Constantinescu A
- Czarnecki PG
- Davis EE
- Doherty D
- Duncan EL
- Filhol E
- Gardiner B
- Gee HY
- Halbritter J
- Hartley JL
- Hildebrandt F
- Hurd TW
- Jones SJ
- Kaplan BS
- Katsanis N
- Kayserili H
- Knebelmann B
- Krantz ID
- Krug P
- Lehman AM
- Leo PJ
- Leroux MR
- Li C
- Maher ER
- McInerney-Leo AM
- McKenzie FA
- Mitchison HM
- Moorani KN
- Nitschké P
- Otto EA
- Porath JD
- Saunier S
- Scambler PJ
- Schmidts M
- Schueler M
- Shah JV
- Szabó AJ
- Tory K
- Trnka P
- Tuysuz B
- UK10K Consortium
- Zankl A
- Zhan SH
- Publication venue
- Publication date
- 07/11/2013
- Field of study
Intraflagellar transport (IFT) depends on two evolutionarily conserved modules, subcomplexes A (IFT-A) and B (IFT-B), to drive ciliary assembly and maintenance. All six IFT-A components and their motor protein, DYNC2H1, have been linked to human skeletal ciliopathies, including asphyxiating thoracic dystrophy (ATD; also known as Jeune syndrome), Sensenbrenner syndrome, and Mainzer-Saldino syndrome (MZSDS). Conversely, the 14 subunits in the IFT-B module, with the exception of IFT80, have unknown roles in human disease. To identify additional IFT-B components defective in ciliopathies, we independently performed different mutation analyses: candidate-based sequencing of all IFT-B-encoding genes in 1,467 individuals with a nephronophthisis-related ciliopathy or whole-exome resequencing in 63 individuals with ATD. We thereby detected biallelic mutations in the IFT-B-encoding gene IFT172 in 12 families. All affected individuals displayed abnormalities of the thorax and/or long bones, as well as renal, hepatic, or retinal involvement, consistent with the diagnosis of ATD or MZSDS. Additionally, cerebellar aplasia or hypoplasia characteristic of Joubert syndrome was present in 2 out of 12 families. Fibroblasts from affected individuals showed disturbed ciliary composition, suggesting alteration of ciliary transport and signaling. Knockdown of ift172 in zebrafish recapitulated the human phenotype and demonstrated a genetic interaction between ift172 and ift80. In summary, we have identified defects in IFT172 as a cause of complex ATD and MZSDS. Our findings link the group of skeletal ciliopathies to an additional IFT-B component, IFT172, similar to what has been shown for IFT-A
The Colorado River system
- Author
- A Pillsbury
- A Pillsbury
- A Strahler
- A Williams
- AB Bishop
- AB Bishop
- AB Bishop
- AJ Stewart
- AM Woodbury
- AW Knight
- B Everitt
- B Walker
- BR Schmidt
- BW Anderson
- BW Anderson
- C Dibble
- C Eriksen
- C Lowe
- CD Vanicek
- CD Vanicek
- CD Vanicek
- CE Dibble
- CE Shannon
- CH Gilbert
- CL Hubbs
- CL Hubbs
- CL Hubbs
- CL Hubbs
- Cross
- D Lehmkuhl
- D Mueller
- D Weber
- DA Bruns
- DA Hoffman
- DB Czarnecki
- DB Simons
- DE Brown
- DE Busch
- DE Busch
- E Ames
- E Graves
- E Larson
- EL Bolke
- ER Anderson
- EW Hansmann
- FR Hauer
- G Crampton
- G Smith
- G Smith
- G Sykes
- G Sykes
- GA Cole
- GD Constantz
- GF Edmunds Jr
- GF Edmunds Jr
- GW Minshall
- H Chronic
- HB Hynes
- HBN Hynes
- HBN Hynes
- HM Tyus
- HR Gould
- J Allan
- J Illies
- J Johnson
- J Johnson
- J Kim
- J Moffett
- J Rinne
- J Rinne
- J Rinne
- J Rinne
- J Turk
- J Ward
- J Ward
- J Ward
- J Williams
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JA Stanford
- JB Laronne
- JC Bequaert
- JC Priscu
- JD Varley
- JE Deacon
- JE Deacon
- JE Deacon
- JE Deacon
- JE Deacon
- JE Williams
- JL Wilhm
- JN Rinne
- JP Collins
- JR Baker
- JR Baker
- JR Webster
- JTF Saur
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JV Ward
- JW Labough
- K Cole
- K Mello
- K Müller
- L Gray
- LJ Gray
- LJ Gray
- LJ Paulson
- LJ Paulson
- LJ Paulson
- LJ Paulson
- LJ Paulson
- LJ Paulson
- LJ Paulson
- LM Mayer
- M. Pénaz
- MJ Winterbourn
- MM Brinson
- N Hundley
- N. T. H. Holmes
- NH Johnson
- NM Johnson
- P Fradkin
- P Greger
- P King
- PB Holden
- PB Holden
- PB King
- PB Moyle
- R Dolan
- R Dolan
- R Dolan
- R Dolan
- R Miller
- R Pennak
- R Pennak
- RA Short
- RA Short
- RA Valdez
- RA Valdez
- RC Euler
- RC Reynolds
- RH Macarthur
- RJ Behnke
- RJ Behnke
- RJ Martinson
- RJ Martinson
- RJ Naiman
- RL Lowe
- RL Vannote
- RM Lee
- RR Miller
- RR Miller
- RR Miller
- RT Prentki
- RT Prentki
- RW Merritt
- RW Wiley
- SA Morgensen
- SG Fisher
- SG Fisher
- SH Lanigan
- SJ Nicola
- SP Canton
- SP Gloss
- SP Gloss
- SP Gloss
- SW Carothers
- SW Carothers
- SW Carothers
- SW Carothers
- SW Carothers
- SW Carothers
- T Mccall
- TH Clark
- UnitedStates Fish
- W Dill
- W Dill
- W Minckley
- W Minckley
- W Minckley
- W Minckley
- W Minckley
- W. D. Pearson
- WJ Miller
- WJ Miller
- WL Minckley
- WL Minckley
- WO Spofford
- WR Courtney Jr
- WR Meehan
- WV Irons
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1986
- Field of study
A classification and systematic review of product line feature model defects
- Author
- A Borning
- A Felfernig
- A van Deursen
- Ajay Kumar
- AO Elfaki
- AO Elfaki
- AO Elfaki
- Arun Negi
- AS Karataş
- B Kitchenham
- C Eduardo
- C Kyo
- C Salinesi
- D Batory
- D Benavides
- D Benavides
- D Benavides
- D Streitferdt
- E Sirin
- F Baader
- F Semmak
- FJ van der Linden
- G Zhang
- G Zhang
- H Wang
- H Ye
- HH Wang
- J Guo
- J Sun
- J White
- J White
- J White
- JV Gurp
- K Czarnecki
- K Czarnecki
- K Czarnecki
- KC Kang
- KC Kang
- KC Kang
- L Rincón
- M Javed
- M Mannion
- M Mendonça
- M Noorian
- Megha Bhushan
- ML Griss
- P Brereton
- P Clements
- P Klaus
- P Trinidad
- P van den Broek
- Piyush Samant
- PY Schobbens
- R Lutz
- R Pohl
- S Ripon
- S Segura
- S Segura
- Shivani Goel
- T Thüm
- T Thüm
- T von der Maßen
- W Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A definition for gamification: anchoring gamification in the service marketing literature
- Author
- B Suits
- BA Jones
- C Czarnecki
- C Grönroos
- C Grönroos
- D Kelley
- DA Norman
- E Arnould
- EJ Arnould
- EM Avedon
- H Dai
- J Hamari
- J Hamari
- J Hamari
- J Hamari
- J Hamari
- J Hense
- J Juul
- J Simões
- JH Jung
- JJ Gibson
- JM Greeno
- Juho Hamari
- JV Bittner
- Kai Huotari
- KR Christy
- M Cocosila
- M Csíkszentmihályi
- M Filsecker
- MJ Bitner
- MT Bonde
- N Yee
- P Zhang
- R Alt
- R Farzan
- R Ryan
- R Terlutter
- S Vargo
- SL Vargo
- SL Vargo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Photosynthetic ATPases: purification, properties, subunit isolation and function
- Author
- A Baccarini-Melandri
- A Baccarini-Melandri
- A Binder
- A Binder
- A Gepshtein
- A Gepshtein
- A Gepshtein
- A Hochman
- A Loyola-Guzman
- A Viale
- A Watanabe
- AE Senior
- AE Senior
- AE Senior
- AF Knowles
- BA Baird
- BA Baird
- BC Johansson
- BR Selman
- C Bengis-Garber
- C Carmeli
- C Kayalar
- CA Price
- CJ Howe
- CJ Howe
- CS Andreo
- CS Andreo
- CW Akey
- D Herrin
- D Khananshvili
- D Khananshvili
- DA Harris
- DA Harris
- DB Datta
- DL Foster
- DW Deters
- E Benedetti De
- EH Moase
- ET Krebbers
- F Farron
- F Farron
- FA McEvoy
- FS Esch
- FS Esch
- FW Hulla
- G Girault
- G Zurawski
- GE Anthon
- GE Blair
- H Deno
- H Hesse
- H Hoffman-Falk
- H Kanazawa
- H Müller
- H Sakurai
- H Stan-Lotter
- H Strotmann
- H Strotmann
- H Tiedge
- HA Lardy
- HH Paradies
- HH Paradies
- HJ Lubberding
- HM Younis
- HM Younis
- HM Younis
- HS Penefsky
- HS Penefsky
- HW Müller
- IA Kozlov
- IC Chang
- J Lunardi
- J-D Rochaix
- JA Steele
- JE Walker
- JE Walker
- JG Wise
- JJ Czarnecki
- JS Kahn
- JT Heij de
- JTO Kirk
- JV Moroney
- JV Moroney
- K Shinozaki
- K-H Süss
- K-H Süss
- L Owers-Narhi
- L Posorke
- LC Cantley
- LC Cantley
- LC Cantley
- LR Mendiola-Morgenthaler
- M Avron
- M Avron
- M Futai
- M Saraste
- M Satre
- M Wolf
- M Yoshida
- M Yoshida
- M Yoshida
- M Yoshida
- M-F Carlier
- MA Tiefert
- MA Weiss
- ME Pullman
- MF Bruist
- MJ Runswiek
- MM Margulies
- MW Gray
- N Nelson
- N Nelson
- N Nelson
- N Nelson
- N Nelson
- N Nelson
- N Shavit
- N-H Chua
- P Mitchell
- P Mitchell
- P Westhoff
- P-Y Bouthyette
- PD Bragg
- PD Bragg
- PR Whitfeld
- R Béliveau
- R Humbert
- R Nechushtai
- R Nechushtai
- R Pougeols
- R Rott
- RA Ravizzini
- RD Todd
- RE Kneusel
- RE McCarty
- RG Piccioni
- RH Fillingame
- RJ Berzborn
- RJ Ellis
- RJ Ellis
- RJ Wagenvoord
- RL Cross
- RL Cross
- S Lien
- S Lien
- S Merchant
- S Merchant
- S Ohta
- S Philosoph
- S Philosoph
- S Philosoph
- S Selman-Reimer
- S Selman-Reimer
- SD Dunn
- SP Myers
- T Bakker-Grunwald
- T Noumi
- U Pick
- U Pick
- V Shoshan
- V Shoshan
- VK Vambutas
- Y Hochman
- Y Hochman
- Y Kagawa
- Y Kagawa
- Y Kagawa
- Y Kagawa
- Y Kagawa
- Z Gromet-Elhanan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1985
- Field of study
Steady shear viscous properties
- Author
- A Dufresne
- A Einstein
- AER Westman
- AJ Poslinski
- AJ Poslinski
- AK Doolittle
- AK Doolittle
- AT Mutel
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- AV Shenoy
- B Derjaguin
- B Hinkelmann
- B Hinkelmann
- BA Knutsson
- BC Mutsuddy
- C Hamaker
- CB Henderson
- CD Han
- CD Han
- CD Han
- CD Han
- CD Han
- CE Chaffey
- CG Tan
- CS Park
- CW Ahu
- DC Goel
- DH Droste
- DI Lee
- DL Faulkner
- DM Bigg
- DM Bigg
- DM Bigg
- DM Bigg
- Dow Chemicals
- DR Paul
- DR Saini
- DR Saini
- DR Saini
- DR Saini
- DR Saini
- DR Saini
- E Matijevic
- E.I. du Pont de Nemours and Co
- EA Barringer
- EF Adams
- EP Plueddemann
- F Nazem
- FM Chapman
- G Menges
- GF Eveson
- GJ Jarzebski
- GM Bartenev
- GR Rideal
- GV Vinogradov
- H Eyring
- H Fujita
- H Groto
- H Groto
- H Rumpf
- H Tanaka
- H Tanaka
- HL Luo
- I Czarnecki
- IM Krieger
- J Gurland
- J Kolarik
- J Rajaiah
- JA Mangels
- JA Mangels
- JA Mangels
- JE Ayer
- JF Stamhuis
- JH Dow
- JH Dow
- JH Pritchard
- JL White
- JL White
- JP Whelan
- JR Copeland
- JS Chong
- JV Milewski
- K Lakdawala
- KH Sweeny
- KW Lem
- LA Utracki
- LB Cohen
- LE Nielsen
- LE Nielsen
- LM Althouse
- LR Daley
- M Arina
- M Hancock
- M Takahashi
- M Yamada
- MD Sacks
- MI Kohan
- MJ Edirisinghe
- MJ Edirisinghe
- MJ Edirisinghe
- MJ Edirisinghe
- MS Boira
- MV Parish
- N Minagawa
- N Ouchiyama
- NA Frankel
- NH Taylor
- NJ Mills
- P Peyser
- PA Willermet
- PJ Carreau
- R Bourne
- RES Bretas
- RF Westover
- RJ Crowson
- RJ Crowson
- RJ Farris
- RK Gupta
- RK Gupta
- RM German
- RO Johnson
- S Wu
- SG Ward
- SH Maron
- SJ Monte
- SJ Monte
- T Gillespie
- T Kataoka
- T Kataoka
- T Kataoka
- T Kitano
- T Kitano
- T Kitano
- T Kitano
- T Kitano
- T Nakatsuka
- UV Shenoy
- V Mokube
- VM Lobe
- VP Juskey
- W Stober
- WH Herschel
- WM Lee
- Y Chan
- Y Chan
- Y Ishigure
- Y Suetsugu
- Y Suetsugu
- YG Yanovsky
- YN Sharma
- YS Lipatov
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1999
- Field of study
基因编辑:将基因生物学用于植物育种的工具
- Author
- A Chavez
- A Endo
- A Lloyd
- A Piatek
- AG Hunt
- AG von Arnim
- AJ Ytterberg
- AP Kausch
- AS Richter
- ASN Reddy
- AX Li
- B Minkenberg
- B Ren
- B Wang
- B Zetsche
- BP Kleinstiver
- CJ Xu
- CS Lin
- CX Xue
- D Goslings
- D Kauss
- D Rodriguez-Leal
- E Butelli
- E Pierre-Jerome
- FJ Wang
- GY Duan
- H Nishimasu
- H Zhang
- HG Jia
- HW Zhang
- I Eş
- J Apitz
- J Wang
- JF Li
- JH Hu
- JP Zhou
- JR Shi
- JS Zhang
- JV Jorrín-Novo
- JW Woo
- K Hua
- K Hua
- K Leppek
- K Takahashi
- KA Molla
- KB Xie
- KL Chen
- L Tang
- L Wu
- L Zhang
- LT Hickey
- M Fossi
- M Jiang
- M Morsy
- M Takenaka
- M Zhang
- MA Al-Zeer
- MG Wang
- MM Mahfouz
- O Czarnecki
- QW Shan
- QW Shan
- QW Shan
- R Meskauskiene
- R Pandiarajan
- RF Xu
- RV Espley
- RX Yang
- S Filichkin
- S Kim
- S Lin
- S Soyk
- SC Huber
- SI Beale
- SK Wang
- SK Wang
- SM Liu
- SSA Zaidi
- T Cermak
- T Li
- T Li
- T Oikawa
- T Zimny
- T Čermák
- V Nekrasov
- WT Li
- X Deng
- X Tang
- X Zhou
- XQ Liang
- Y Zong
- YB Li
- YF Mao
- YL Deribe
- YP Wang
- YQ Jiao
- YW Sun
- YX Zhang
- Z Shimatani
- ZR Qin
- Publication venue
- 'Zhejiang University Press'
- Publication date
- Field of study
Drittes Kapitel
- Author
- A Benedicenti
- A Benedicenti
- A Bylina
- A Desgrez
- A Frouin
- A Frouin
- A Frouin
- A Gizelt
- A Henry
- A Hustin
- A. C. Ivy
- AB Luckhardt
- AB Luckhardt
- AC Ivy
- AE Zilwa
- AJ Smirnow
- Anrep
- Außer den oben genannten Arbeiten von Popielski vgl. ferner: Über den Charakter der Sekretionstätigkeit des Pankreas unter dem Einfluß von Salz-Popielski
- B Gutowski
- Babkin
- Babkin
- Babkin
- Babkin
- Babkin
- Babkin
- Babkin
- Barger
- Barger
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss
- Bayliss and Starling
- Bierry
- BP Babkin
- BP Babkin
- BP Babkin
- BP Babkin
- BP Babkin
- Bylina
- Bylina
- C Bernard
- C Delezenne
- C Delezenne
- C Delezenne
- C Delezenne
- C Fleig
- C Fleig
- C Fleig
- C Fleig
- C Fleig
- C Fleig
- C Fleig
- C Fleig
- C Voegtlin
- C Voegtlin
- C. W. Edmunds
- Camus
- Camus
- Camus
- Camus
- Camus
- Camus
- Camus
- CL Evans
- CW Edmunds
- CW Edmunds
- Delezenne
- Divry
- Dixon
- Dobreff
- Downs and Eddy
- E Czarnecki
- E Gley
- E Gley
- E Gley
- E Gley
- E Hédon
- E Parsons
- E Peserico
- E Sieheauch
- E Wertheimer
- E Wertheimer
- E Wertheimer
- E Wertheimer
- E Wertheimer
- E Wertheimer
- E Zunz
- E Zunz
- E Zunz
- E Zunz
- EA Starling
- Enriquez
- F Bottazzi
- F Czubalski
- FA Bainbridge
- FC Mann
- François-Frank
- G Modrakowski
- G Modrakowski
- G Métivet
- G. Anrep
- G. Anrep
- G. V. Anrep
- Gley
- Gley
- Gley
- GR Cowgill
- GR Cowgill
- GW Volborth
- H Bierry
- H Necheles
- H Stassano
- Heidenhain
- HH Dale
- HH Dale
- HH Dale
- I Rogers
- I. Matsuo
- J Lalou
- J Mellanby
- J Mellanby
- J Pawlow
- J Piticarin
- J Rogers
- J. Derouaux
- J. G. Braga
- J. Matsuo
- JI Farrell
- JT King
- JV Anrep
- K Djenab
- K Djenab
- K Gläßner
- K Schimizu
- Kühne und Lea: Untersuch. a. d. physiol. Inst. Heidelberg 2 474. 1882. Zit. nach Metzner, R.
- L Camus
- L Camus
- L Camus
- L Camus
- L Camus
- L Camus
- L Camus
- L Camus
- L Launoy
- L Launoy
- L Launoy
- L Morel
- L Morel
- L Popielski
- L Popielski
- L. Popielski
- Lalou
- Lalou
- Langley
- Lim
- M Afanassiew
- M Arthus
- M Dobreff
- M Dobreff
- M Lambert
- M Pitzorno
- M Skarzynska
- M Skarzynska
- Matsuoka
- Mellanby
- Mellanby
- Mellanby
- MM Weaver
- Modrakowski
- Modrakowski
- Modrakowski
- Morel
- N Burdenko
- NB Eddy
- O Fürth
- O Fürth
- O May
- P Borissow
- P Divry
- Popielski
- Popielski
- Popielski
- Popielski
- Popielski
- Popielski
- PT Herring
- PT Herring
- R Gottlieb
- R Grogan
- R Heidenhain
- R Pemberton
- R Pemberton
- R Pemberton
- S Lalou
- S Lalou
- S Lalou
- Tonkich
- V Paglione
- Vergoz
- Volborth
- Volborth
- W Stepp
- W. M. Bayliss
- W. Stepp
- WD Halliburton
- WD Halliburton
- WE Dixon
- Wertheimer
- Wertheimer
- Wertheimer
- Wertheimer
- Wertheimer
- Wertheimer
- WM Bayliss
- WM Bayliss
- WS Collens
- Zilwa
- zu S. 623) May
- Zunz
- Zunz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1928
- Field of study
Graded Subdifferentials, Ioffe Subdifferentials
- Author
- A Arutyunov
- A Auslender
- A Auslender
- A Auslender
- A Auslender
- A Auslender
- A Avez
- A Bacciotti
- A Bakan
- A Bourass
- A Bressan
- A Bressan
- A Brøndsted
- A Brøndsted
- A Cellina
- A Cellina
- A Cellina
- A Coulibaly
- A Daniilidis
- A Daniilidis
- A Eberhard
- A Ferriero
- A Friedman
- A Granas
- A Gudovich
- A Hantoute
- A Ioffe
- A Ioffe
- A Ioffe
- A Ioffe
- A Jofré
- A Jofré
- A Jofré
- A Jofré
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Jourani
- A Lewis
- A Nijenhuis
- A Uderzo
- A Uderzo
- AB Ben-Tal
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AB Levy
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Ioffe
- AD Michal
- AD Michal
- AF Filippov
- AH Hamel
- AJ Hoffman
- AJ Kurdila
- AL Dontchev
- AL Dontchev
- AL Dontchev
- AL Dontchev
- AL Dontchev
- AL Dontchev
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- T Amahroq
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- T Zolezzi
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- T.X.D. Ha
- U Mosco
- V Barbu
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