189 research outputs found
Chemotherapy in conjoint aging-tumor systems: some simple models for addressing coupled aging-cancer dynamics
Background
In this paper we consider two approaches to examining the complex dynamics of conjoint aging-cancer cellular systems undergoing chemotherapeutic intervention. In particular, we focus on the effect of cells growing conjointly in a culture plate as a precursor to considering the larger multi-dimensional models of such systems. Tumor cell growth is considered from both the logistic and the Gompertzian case, while normal cell growth of fibroblasts (WI-38 human diploid fibroblasts) is considered as logistic only. Results
We demonstrate, in a simple approach, how the interdependency of different cell types in a tumor, together with specifications of for treatment, can lead to different evolutionary patterns for normal and tumor cells during a course of therapy. Conclusions
These results have significance for understanding appropriate pharmacotherapy for elderly patients who are also undergoing chemotherapy
Holographic Superconductors in a Cohesive Phase
We consider a four-dimensional N=2 gauged supergravity coupled to matter
fields. The model is obtained by a U(1) gauging of a charged hypermultiplet and
therefore it is suitable for the study of holographic superconductivity. The
potential has a topologically flat direction and the parameter running on this
"moduli space" labels the new superconducting black holes. Zero temperature
solutions are constructed and the phase diagram of the theory is studied. The
model has rich dynamics. The retrograde condensate is just a special case in
the new class of black holes. The calculation of the entanglement entropy makes
manifest the properties of a generic solution and the superconductor at zero
temperature is in a confined cohesive phase. The parameter running on the
topologically flat direction is a marginal coupling in the dual field theory.
We prove this statement by considering the way double trace deformations are
treated in the AdS/CFT correspondence. Finally, we comment on a possible
connection, in the context of gauge/gravity dualities, between the geometry of
the scalar manifold in N=2 supergravity models and the space of marginal
deformations of the dual field theory.Comment: 32 pages, 11 figures. Introduction rewritten and clarified, comments
and details on section 4 added, acknowledgements rectified. To appear in JHE
Pseudo-Killing Spinors, Pseudo-supersymmetric p-branes, Bubbling and Less-bubbling AdS Spaces
We consider Einstein gravity coupled to an n-form field strength in D
dimensions. Such a theory cannot be supersymmetrized in general, we
nevertheless propose a pseudo-Killing spinor equation and show that the AdS X
Sphere vacua have the maximum number of pseudo-Killing spinors, and hence are
fully pseudo-supersymmetric. We show that extremal p-branes and their
intersecting configurations preserve fractions of the pseudo-supersymmetry. We
study the integrability condition for general (D,n) and obtain the additional
constraints that are required so that the existence of the pseudo-Killing
spinors implies the Einstein equations of motion. We obtain new
pseudo-supersymmetric bubbling AdS_5 X S^5 spaces that are supported by a
non-self-dual 5-form. This demonstrates that non-supersymmegtric conformal
field theories may also have bubbling states of arbitrary droplets of free
fermions in the phase space. We also obtain an example of less-bubbling AdS
geometry in D=8, whose bubbling effects are severely restricted by the
additional constraint arising from the integrability condition.Comment: typos corrected, extra comments and references added, version
appeared in JHE
Four-Dimensional SCFTs from M5-Branes
We engineer a large new set of four-dimensional N=1 superconformal field
theories by wrapping M5-branes on complex curves. We present new supersymmetric
AdS_5 M-theory backgrounds which describe these fixed points at large N, and
then directly construct the dual four-dimensional CFTs for a certain subset of
these solutions. Additionally, we provide a direct check of the central charges
of these theories by using the M5-brane anomaly polynomial. This is a companion
paper which elaborates upon results reported in arXiv:1112:5487.Comment: 45 pages, 11 figure
Holographic Lovelock Gravities and Black Holes
We study holographic implications of Lovelock gravities in AdS spacetimes.
For a generic Lovelock gravity in arbitrary spacetime dimensions we formulate
the existence condition for asymptotically AdS black holes. We consider small
fluctuations around these black holes and determine the constraint on Lovelock
parameters by demanding causality of the boundary theory. For the case of cubic
Lovelock gravity in seven spacetime dimensions we compute the holographic Weyl
anomaly and determine the three point functions of the stress energy tensor in
the boundary CFT. Remarkably, these correlators happen to satisfy the same
relation as the one imposed by supersymmetry. We then compute the energy flux;
requiring it to be positive is shown to be completely equivalent to requiring
causality of the finite temperature CFT dual to the black hole. These
constraints are not stringent enough to place any positive lower bound on the
value of viscosity. Finally, we conjecture an expression for the energy flux
valid for any Lovelock theory in arbitrary dimensions.Comment: 31 pages, 1 figure, harvmac, references added, calculation of
viscosity/entropy ratio include
Black Holes in Quasi-topological Gravity
We construct a new gravitational action which includes cubic curvature
interactions and which provides a useful toy model for the holographic study of
a three parameter family of four- and higher-dimensional CFT's. We also
investigate the black hole solutions of this new gravity theory. Further we
examine the equations of motion of quasi-topological gravity. While the full
equations in a general background are fourth-order in derivatives, we show that
the linearized equations describing gravitons propagating in the AdS vacua
match precisely the second-order equations of Einstein gravity.Comment: 33 pages, 4 figures; two references adde
Lifshitz black holes in string theory
We provide the first black hole solutions with Lifshitz asymptotics found in
string theory. These are expected to be dual to models enjoying anisotropic
scale invariance with dynamical exponent z=2 at finite temperature. We employ a
consistent truncation of type IIB supergravity to four dimensions with an
arbitrary 5-dimensional Einstein manifold times a circle as internal geometry.
New interesting features are found that significantly differ from previous
results in phenomenological models. In particular, small black holes are shown
to be thermodynamically unstable, analogously to the usual AdS-Schwarzschild
black holes, and extremality is never reached. This signals a possible
Hawking-Page like phase transition at low temperatures.Comment: 19 pages, 7 figures. v2 references adde
Reducing bias in auditory duration reproduction by integrating the reproduced signal
Duration estimation is known to be far from veridical and to differ for sensory estimates and motor reproduction. To investigate how these differential estimates are integrated for estimating or reproducing a duration and to examine sensorimotor biases in duration comparison and reproduction tasks, we compared estimation biases and variances among three different duration estimation tasks: perceptual comparison, motor reproduction, and auditory reproduction (i.e. a combined perceptual-motor task). We found consistent overestimation in both motor and perceptual-motor auditory reproduction tasks, and the least overestimation in the comparison task. More interestingly, compared to pure motor reproduction, the overestimation bias was reduced in the auditory reproduction task, due to the additional reproduced auditory signal. We further manipulated the signal-to-noise ratio (SNR) in the feedback/comparison tones to examine the changes in estimation biases and variances. Considering perceptual and motor biases as two independent components, we applied the reliability-based model, which successfully predicted the biases in auditory reproduction. Our findings thus provide behavioral evidence of how the brain combines motor and perceptual information together to reduce duration estimation biases and improve estimation reliability
Holographic Renormalization and Stress Tensors in New Massive Gravity
We obtain holographically renormalized boundary stress tensors with the
emphasis on a special point in the parameter space of three dimensional new
massive gravity, using the so-called Fefferman-Graham coordinates with relevant
counter terms. Through the linearized equations of motion with a standard
prescription, we also obtain correlators among these stress tensors. We argue
that the self-consistency of holographic renormalization determines counter
terms up to unphysical ambiguities. Using these renormalized stress tensors in
Fefferman-Graham coordinates, we obtain the central charges of dual CFT, and
mass and angular momentum of some black hole solutions. These results are
consistent with the previous ones obtained by other methods. In this study on
the Fefferman-Graham expansion of new massive gravity, some aspects of higher
curvature gravity are revealed.Comment: Version accepted for publication in JHEP, conclusion revised,
references adde
Anomalous Dimensions of Non-Chiral Operators from AdS/CFT
Non-chiral operators with positive anomalous dimensions can have interesting
applications to supersymmetric model building. Motivated by this, we develop a
new method for obtaining the anomalous dimensions of non-chiral double-trace
operators in N=1 superconformal field theories (SCFTs) with weakly-coupled AdS
duals. Via the Hamiltonian formulation of AdS/CFT, we show how to directly
compute the anomalous dimension as a bound state energy in the gravity dual.
This simplifies previous approaches based on the four-point function and the
OPE. We apply our method to a class of effective AdS5 supergravity models, and
we find that the binding energy can have either sign. If such models can be UV
completed, they will provide the first calculable examples of SCFTs with
positive anomalous dimensions.Comment: 38 pages, 2 figures, refs adde
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