Attention-dependent modulation of cortical taste circuits revealed by granger causality with signal-dependent noise

We show, for the first time, that in cortical areas, for example the insular, orbitofrontal, and lateral prefrontal cortex, there is signal-dependent noise in the fMRI blood-oxygen level dependent (BOLD) time series, with the variance of the noise increasing approximately linearly with the square of the signal. Classical Granger causal models are based on autoregressive models with time invariant covariance structure, and thus do not take this signal-dependent noise into account. To address this limitation, here we describe a Granger causal model with signal-dependent noise, and a novel, likelihood ratio test for causal inferences. We apply this approach to the data from an fMRI study to investigate the source of the top-down attentional control of taste intensity and taste pleasantness processing. The Granger causality with signal-dependent noise analysis reveals effects not identified by classical Granger causal analysis. In particular, there is a top-down effect from the posterior lateral prefrontal cortex to the insular taste cortex during attention to intensity but not to pleasantness, and there is a top-down effect from the anterior and posterior lateral prefrontal cortex to the orbitofrontal cortex during attention to pleasantness but not to intensity. In addition, there is stronger forward effective connectivity from the insular taste cortex to the orbitofrontal cortex during attention to pleasantness than during attention to intensity. These findings indicate the importance of explicitly modeling signal-dependent noise in functional neuroimaging, and reveal some of the processes involved in a biased activation theory of selective attention

Testing in Mice the Hypothesis That Melanin Is Protective in Malaria Infections

Malaria has had the largest impact of any infectious disease on shaping the human genome, exerting enormous selective pressure on genes that improve survival in severe malaria infections. Modern humans originated in Africa and lost skin melanization as they migrated to temperate regions of the globe. Although it is well documented that loss of melanization improved cutaneous Vitamin D synthesis, melanin plays an evolutionary ancient role in insect immunity to malaria and in some instances melanin has been implicated to play an immunoregulatory role in vertebrates. Thus, we tested the hypothesis that melanization may be protective in malaria infections using mouse models. Congenic C57BL/6 mice that differed only in the gene encoding tyrosinase, a key enzyme in the synthesis of melanin, showed no difference in the clinical course of infection by Plasmodium yoelii 17XL, that causes severe anemia, Plasmodium berghei ANKA, that causes severe cerebral malaria or Plasmodium chabaudi AS that causes uncomplicated chronic disease. Moreover, neither genetic deficiencies in vitamin D synthesis nor vitamin D supplementation had an effect on survival in cerebral malaria. Taken together, these results indicate that neither melanin nor vitamin D production improve survival in severe malaria

The 'antisocial' person: an insight in to biology, classification and current evidence on treatment

<p>Abstract</p> <p>Background</p> <p>This review analyses and summarises the recent advances in understanding the neurobiology of violence and empathy, taxonomical issues on defining personality disorders characterised by disregard for social norms, evidence for efficacy of different treatment modalities and ethical implications in defining 'at-risk' individuals for preventive interventions.</p> <p>Methods</p> <p>PubMed was searched with the keywords 'antisocial personality disorder', 'dissocial personality disorder' and 'psychopathy'. The search was limited to articles published in English over the last 10 years (1999 to 2009)</p> <p>Results</p> <p>Both diagnostic manuals used in modern psychiatry, the <it>Diagnostic and Statistical Manual </it>published by the American Psychiatric Association and the <it>International Classification of Diseases </it>published by the World Health Organization, identify a personality disorder sharing similar traits. It is termed antisocial personality disorder in the diagnostic and statistical manual and dissocial personality disorder in the <it>International Classification of Diseases</it>. However, some authors query the ability of the existing manuals to identify a special category termed 'psychopathy', which in their opinion deserves special attention. On treatment-related issues, many psychological and behavioural therapies have shown success rates ranging from 25% to 62% in different cohorts. Multisystemic therapy and cognitive behaviour therapy have been proven efficacious in many trials. There is no substantial evidence for the efficacy of pharmacological therapy. Currently, the emphasis is on early identification and prevention of antisocial behaviour despite the ethical implications of defining at-risk children.</p> <p>Conclusions</p> <p>Further research is needed in the areas of neuroendocrinological associations of violent behaviour, taxonomic existence of psychopathy and efficacy of treatment modalities.</p

A Rapid Decision Sampling Plan for Implementing Area—Wide Management of the Red Palm Weevil, Rhynchophorus ferrugineus, in Coconut Plantations of India

The red palm weevil Rhynchophorus ferrugineus Olivier (Curculionidae/Rhynchophoridae/Dryophthoridae) is a lethal pest of young coconut palms, Cocos nucifera L. (Arecales: Arecaceae), with a highly aggregated population distribution pattern. R. ferrugineus is managed in several coconut growing countries using area-wide pheromone based programmes that need a substantial commitment of funds over a period of time. Often, decisions to implement area-wide management of R. ferrugineus are based on pheromone trap captures in surveillance traps and or infestation reports. Implementing area-wide management of this pest on the basis of such data can be inaccurate, as it may either under or over estimate the pest intensity in the field. This study presents sampling plans for rapid and accurate classification of R. ferrugineus infestation in coconut plantations of India by inspecting palms to detect infestation in a sequence until a decision to either implement or not to initiate area-wide management of R. ferrugineus can be made. The sampling plans are based on a common aggregation index of 3.45, assumed action threshold values of either 1.0 (plan A) or 0.5 (plan B) per cent infested palms and a risk factor of making the wrong decision set at 0.05. Using plans A and B, if the cummulative number of infested palms in a young 1 hectare coconut plantation is zero out of 150 palms for both plans, then area-wide management is not required, while on the other hand, if the cummulative number of infested palms for the same area is 6 (plan A), or 5 (plan B), then area-wide management of R. ferrugineus is essential. The proposed sampling plans are efficient tools in decision making, particularly at very low and high levels of infestation and can also be used to assess the performance of R. ferrugineus IPM programmes that are in progress. These plans not only save time and money as only a small area needs to be sampled to arrive at a correct decision, but are also efficient in rating the infestation level accurately

Prototype implementation of an islanding detection relay based on pattern classification of current and voltage transients

A prototype islanding detection relay, which uses decision tree classifier to categorize the transient generating events as ‘islanding’ or ‘non-islanding’ was implemented and tested. It consisted of two basic stages of signal processing to extract the required feature vectors for the classification. The first stage involved signal filtering and in the second stage signals were processed by rectifying, summing, and lowpass filtering to get the energy content in the three phases during a selected time-frame. A simple radial medium voltage distribution system having a single distributed generator was simulated in PSCAD/EMTDC to obtain the transient waveforms, and the performance of the relay was tested with signals generated using an RTP real-time waveform playback instrument. The experimental results showed high accuracy in detecting islanding events within a response time of less than two cycles. The proposed relay can be implemented with a very low cost and is simple in construction. Therefore, this could be an acceptable low cost substitute for the expensive and complex transfer trip schemes, which are commonly in use with the distributed generation. loads and distributed energy resources (DER) remains energized while isolated from the remainder of the utility system’ (IEEE, 2003). Unintentional islanding resultsin several safety and power quality' issues including abnormal variations in frequency and voltage, possibility of creating ungrounded systems, and potential safety hazards for repair crews. In formulating guidelines and/or rules for interconnecting DGs in the distribution systems, the most common practice is to adopt the IEEE standard 154 (IEEE, 2003). These otional practice standards have been developed with an underlying assumption that thepower system is radial. In the past, the power available from DGs was not essential to support the load on the system. Hence, the standards suggest to disconnect the DGs for any ‘significant’ fault (a fault that could require the protection to be provoked) on the distribution system and thus, maintaining the radial nature of the system. Consequently, the islanding detection relays are designed to avoid power islanding, and these relays are referred to as anti-islanding relays (Xu et al., 2004; Mahat et al., 2008). However, there is a change in the approach towards islanding with the initiatives on microgrids (Chowdhury et al., 2009; Lidula & Rajapakse, 2011). The performance of the power-islanding detection methods in a microgrid setup is more demanding as the microgrid is designed to operate as a stable power island. Many powerislanding detection methods in practice would find it difficult to meet the qualities demanded by micorgrids (Katiraei et al., 2005) without the use of expensive telecommunication facilities. Keywords: Active filters, decision tree classifica

Prototype implementation of an islanding detection relay based on pattern classification of current and voltage transients

A prototype islanding detection relay, which uses decision tree classifier to categorize the transient generating events as ‘islanding’ or ‘non-islanding’ was implemented and tested. It consisted of two basic stages of signal processing to extract the required feature vectors for the classification. The first stage involved signal filtering and in the second stage signals were processed by rectifying, summing, and lowpass filtering to get the energy content in the three phases during a selected time-frame. A simple radial medium voltage distribution system having a single distributed generator was simulated in PSCAD/EMTDC to obtain the transient waveforms, and the performance of the relay was tested with signals generated using an RTP real-time waveform playback instrument. The experimental results showed high accuracy in detecting islanding events within a response time of less than two cycles. The proposed relay can be implemented with a very low cost and is simple in construction. Therefore, this could be an acceptable low cost substitute for the expensive and complex transfer trip schemes, which are commonly in use with the distributed generation. loads and distributed energy resources (DER) remains energized while isolated from the remainder of the utility system’ (IEEE, 2003). Unintentional islanding resultsin several safety and power quality' issues including abnormal variations in frequency and voltage, possibility of creating ungrounded systems, and potential safety hazards for repair crews. In formulating guidelines and/or rules for interconnecting DGs in the distribution systems, the most common practice is to adopt the IEEE standard 154 (IEEE, 2003). These otional practice standards have been developed with an underlying assumption that thepower system is radial. In the past, the power available from DGs was not essential to support the load on the system. Hence, the standards suggest to disconnect the DGs for any ‘significant’ fault (a fault that could require the protection to be provoked) on the distribution system and thus, maintaining the radial nature of the system. Consequently, the islanding detection relays are designed to avoid power islanding, and these relays are referred to as anti-islanding relays (Xu et al., 2004; Mahat et al., 2008). However, there is a change in the approach towards islanding with the initiatives on microgrids (Chowdhury et al., 2009; Lidula & Rajapakse, 2011). The performance of the power-islanding detection methods in a microgrid setup is more demanding as the microgrid is designed to operate as a stable power island. Many powerislanding detection methods in practice would find it difficult to meet the qualities demanded by micorgrids (Katiraei et al., 2005) without the use of expensive telecommunication facilities. Keywords: Active filters, decision tree classifica

Strength properties of composite clay balls containing additives from industry wastes as new filter media in water treatment

Pebble matrix filtration (PMF) is a water treatment technology that can remove suspended solids in highly turbid surface water during heavy storms. PMF typically uses sand and natural pebbles as filter media. Hand-made clay pebbles (balls) can be used as alternatives to natural pebbles in PMF treatment plants, where natural pebbles are not readily available. Since the high turbidity is a seasonal problem that occurs during heavy rains, the use of newly developed composite clay balls instead of pure clay balls have the advantage of removing other pollutants such as natural organic matter (NOM) during other times. Only the strength properties of composite clay balls are described here as the pollutant removal is beyond the scope of this paper. These new composite clay balls must be able to withstand dead and live loads under dry and saturated conditions in a filter assembly. Absence of a standard ball preparation process and expected strength properties of composite clay balls were the main reasons behind the present study. Five different raw materials from industry wastes: Red Mud (RM), Water Treatment Alum Sludge (S), Shredded Paper (SP), Saw Dust (SD), and Sugar Mulch (SM) were added to common clay brick mix (BM) in different proportions. A comprehensive experimental program was performed to evaluate influence burning temperature on crushing strength of composite hand-made clay balls, using uniaxial compression test to establish the best material combination on the basis of strength properties for designing sustainable filter media for water treatment plants. Performance at both construction and operating stages were considered by analyzing both strength properties under fully dry conditions and strength degradation after saturation in a water bath. Approximately 50 mm diameter composite clay balls fired at 800 0C provided sufficient strength for water treatment applications at both construction and operational stages due to their higher strength at dry conditions, and no strength degradation at soaked conditions. The use of water treatment sludge as an additive produced the lowest strength of composite clay balls, with a failure load of 1.4 kN. However, this value is much higher than the effective load on each clay ball of 0.04 kN in a typical filter assembly (safety factor of 35), therefore, can still be used as a suitable filter material for enhanced pollutant removal.Authors wish to thank Queensland Alumina Limited (QAL) and Seqwater for supplying Red Mud and water treatment sludge for the experiments. The support of PGH Bricks and Pavers for firing composite clay balls in their factory is greatly acknowledged. Also, the support of technical and professional staff of the geotechnical laboratory at Queensland University of Technology during testing is highly appreciated.This is a metadata record relating to an article that cannot be shared due to publisher copyright

Strength properties of composite clay balls containing additives from industry wastes as new filter media in water treatment

Pebble matrix filtration (PMF) is a water treatment technology that can remove suspended solids in highly turbid surface water during heavy storms. PMF typically uses sand and natural pebbles as filter media. Hand-made clay pebbles (balls) can be used as alternatives to natural pebbles in PMF treatment plants, where natural pebbles are not readily available. Since the high turbidity is a seasonal problem that occurs during heavy rains, the use of newly developed composite clay balls instead of pure clay balls have the advantage of removing other pollutants such as natural organic matter (NOM) during other times. Only the strength properties of composite clay balls are described here as the pollutant removal is beyond the scope of this paper. These new composite clay balls must be able to withstand dead and live loads under dry and saturated conditions in a filter assembly. Absence of a standard ball preparation process and expected strength properties of composite clay balls were the main reasons behind the present study. Five different raw materials from industry wastes: Red Mud (RM), Water Treatment Alum Sludge (S), Shredded Paper (SP), Saw Dust (SD), and Sugar Mulch (SM) were added to common clay brick mix (BM) in different proportions. In an effort to minimize costs, in this study clay balls were fired to 1100°C at a local brick factory together with their bricks. A comprehensive experimental program was performed to evaluate crushing strength of composite hand-made clay balls, using uniaxial compression test to establish the best material combination on the basis of strength properties for designing sustainable filter media for water treatment plants. Performance at both construction and operating stages were considered by analyzing both strength properties under fully dry conditions and strength degradation after saturation in a water bath. The BM-75% as the main component produced optimum combination in terms of workability and strength. With the material combination of BM-75% and additives-25%, the use of Red Mud and water treatment sludge as additives produced the highest and lowest strength of composite clay balls, with a failure load of 5.4 kN and 1.4 kN respectively. However, this lower value of 1.4 kN is much higher than the effective load on each clay ball of 0.04 kN in a typical filter assembly (safety factor of 35), therefore, can still be used as a suitable filter material for enhanced pollutant removal