Discovering Successful Second Language Teaching Strategies and Practices: From Programme Evaluation to Classroom Experimentation

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Criminal Careers Among Female Perpetrators of Family and Non-family Homicide in Australia

Knowledge of women’s pathways to serious offending, including homicide, is limited. This study contributes to a small but growing body of literature examining the criminal careers of serious female offenders by using interview data with females convicted of murder or manslaughter in Australia to examine various dimensions of their criminal careers, specifically, prevalence, frequency, age of onset, duration, and offending variety. In particular, in this study we compared criminal career dimensions across women who had killed a family member (e.g., intimate partner, children) and those whose victims were not part of the family unit (i.e., acquaintances or strangers). Our findings reveal differences between female homicide offenders who kill within and outside of the family unit. Although both groups had comparable overall lifetime prevalence of self-reported participation in criminal offending, findings indicate that participation among the family group was typically at low levels of frequency, of limited duration, and with relatively little variety in categories of offending. The family group also reported lower contact with the criminal justice system compared with the nonfamily group, and were less likely to have experienced some form of criminal/legal sanction in the 12 months prior to the homicide incident. This suggests that women who kill family members are more “conventional” than their nonfamily counterparts, in terms of having low and time-limited (i.e., short duration) lifetime participation in criminal offending

From core to content: bridging the L2 proficiency gap in late immersion

In this paper we argue that assumptions which underlie the successful implementation of early immersion education may not be valid for late immersion education. In particular, assumptions about the curriculum that hold for early immersion (e.g. that the same content can be covered) and the pedagogy (e.g. that there is no place for the use of the L1 by students or teachers) may need to be reconsidered in the context of late immersion . The reason for these differences lies in the nature and extent of the L2 proficiency gap experienced by late immersion students as they begin their immersion experience. The paper concludes with some suggestions for research focusing on curricular issues and pedagogy in late immersion education.published_or_final_versio

The local economic development processes in low-income countries: the case of the metropolis of Chegutu in Zimbabwe

Local authorities are widely regarded as catalysts accelerating localised processes of economic development in industrialised countries but in low-income countries they are perceived as dysfunctional, inefficient and ineffective in meeting and addressing societal demands. This abstract view is however, not grounded in empirical research. As such, utilising the case of the metropolis of Chegutu a survey was designed to empirically explicate the economic processes militating its economic development. The findings are useful to policy-makers, local government authorities and management scholars. The study's unique contribution lies in its examination of the processes of local economic development in a low-income country

Design and function of superfast muscles : new insights into the physiology of skeletal muscle

First published online as a Review in Advance on October 24, 2005. (Some corrections may occur before final publication online and in print)Author Posting. © Annual Reviews, 2005. This article is posted here by permission of Annual Reviews for personal use, not for redistribution. The definitive version was published in Annual Review of Physiology 68 (2006): 22.1-22.29, doi:10.1146/annurev.physiol.68.040104.105418.Superfast muscles of vertebrates power sound production. The fastest, the swimbladder muscle of toadfish, generates mechanical power at frequencies in excess of 200 Hz. To operate at these frequencies, the speed of relaxation has had to increase approximately 50-fold. This increase is accomplished by modifications of three kinetic traits: (a) a fast calcium transient due to extremely high concentration of sarcoplasmic reticulum (SR)-Ca2+ pumps and parvalbumin, (b) fast off-rate of Ca2+ from troponin C due to an alteration in troponin, and (c) fast cross-bridge detachment rate constant (g, 50 times faster than that in rabbit fast-twitch muscle) due to an alteration in myosin. Although these three modifications permit swimbladder muscle to generate mechanical work at high frequencies (where locomotor muscles cannot), it comes with a cost: The high g causes a large reduction in attached force-generating cross-bridges, making the swimbladder incapable of powering low-frequency locomotory movements. Hence the locomotory and sound-producing muscles have mutually exclusive designs.This work was made possible by support from NIH grants AR38404 and AR46125 as well as the University of Pennsylvania Research Foundation

Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by ^1H molecular diffusion NMR and ^(19)F spin diffusion NMR

R_f-PEG (fluoroalkyl double-ended poly(ethylene glycol)) hydrogel is potentially useful as a drug delivery depot due to its advanced properties of sol–gel two-phase coexistence and low surface erosion. In this study, ^1H molecular diffusion nuclear magnetic resonance (NMR) and ^(19)F spin diffusion NMR were used to probe the drug loading and diffusion properties of the R_f-PEG hydrogel for small anticancer drugs, 5-fluorouracil (FU) and its hydrophobic analog, 1,3-dimethyl-5-fluorouracil (DMFU). It was found that FU has a larger apparent diffusion coefficient than that of DMFU, and the diffusion of the latter was more hindered. The result of ^(19)F spin diffusion NMR for the corresponding freeze-dried samples indicates that a larger portion of DMFU resided in the R_f core/IPDU intermediate-layer region (where IPDU refers to isophorone diurethane, as a linker to interconnect the R_f group and the PEG chain) than that of FU while the opposite is true in the PEG–water phase. To understand the experimental data, a diffusion model was proposed to include: (1) hindered diffusion of the drug molecules in the R_f core/IPDU-intermediate-layer region; (2) relatively free diffusion of the drug molecules in the PEG-water phase (or region); and (3) diffusive exchange of the probe molecules between the above two regions. This study also shows that molecular diffusion NMR combined with spin diffusion NMR is useful in studying the drug loading and diffusion properties in hydrogels for the purpose of drug delivery applications

Use of mixed methods designs in substance research: a methodological necessity in Nigeria

The utility of mixed methods (qualitative and quantitative) is becoming increasingly accepted in health sciences, but substance studies are yet to substantially benefit from such utilities. While there is a growing number of mixed methods alcohol articles concerning developed countries, developing nations are yet to embrace this method. In the Nigerian context, the importance of mixed methods research is yet to be acknowledged. This article therefore, draws on alcohol studies to argue that mixed methods designs will better equip scholars to understand, explore, describe and explain why alcohol consumption and its related problems are increasing in Nigeria. It argues that as motives for consuming alcohol in contemporary Nigeria are multiple, complex and evolving, mixed method approaches that provide multiple pathways for proffering solutions to problems should be embraced