Haemostatics in surgery and our experience in the enucleoresection of renal cell carcinoma

<p>Abstract</p> <p>Background</p> <p>30 patients, with T1 renal cell carcinomas (RCC) who underwent open enucleoresection of the tumour, were randomized to the use of a topical haemostatic agent (Floseal) or to an infrared-sapphire coagulator (ISC), to compare their efficacy in achieving haemostasis. Methods: Successful intra-operative haemostasis, intra- and post-operative bleeding, operative time, hospital discharge were evaluated.</p> <p>Results</p> <p>Statistically higher rates of successful haemostasis and shorter time-to-haemostasis (8,1 vs 12,9 min) were observed in the FloSeal group (p < 0.001 both). Patients operative time was not different between Group 1 vs 2 (58.7 ± 12 vs 62.4 ± 15; p > 0.05). The average blood loss during surgery was less (60 +/- 25.5 mL) for the FloSeal group than for the ISC group (85 +/- 40.5 mL) (p < 0.05). Postoperative blood loss was 25 +/- 5 mL and 40 +/- 45 mL for Floseal and ISC respectively, (p < 0.05). Length of the postoperative hospital discharge was 2.5 +/- 1.2 days for FloSeal group and 3.5 +/- 1.3 for the Group 2 (p < 0.05). No major immediate or delayed complications were observed in either Groups.</p> <p>Conclusions</p> <p>The use of Floseal and ISC offer a safe and efficacy haemostasis in the enucleoresection of RCC. Moreover, our results show a less intra-operative and post-operative blood loss as well as a shorter time to haemostasis of Floseal in respect to ISC.</p

First measurement of quasi-elastic Λ\Lambda baryon production in muon anti-neutrino interactions in the MicroBooNE detector

We present the first measurement of the cross section of Cabibbo-suppressed $\Lambda$ baryon production, using data collected with the MicroBooNE detector when exposed to the neutrinos from the Main Injector beam at the Fermi National Accelerator Laboratory. The data analyzed correspond to $2.2 \times 10^{20}$ protons on target of neutrino mode running and $4.9 \times 10^{20}$ protons on target of anti-neutrino mode running. An automated selection is combined with hand scanning, with the former identifying five candidate $\Lambda$ production events when the signal was unblinded, consistent with the GENIE prediction of $5.3 \pm 1.1$ events. Several scanners were employed, selecting between three and five events, compared with a prediction from a blinded Monte Carlo simulation study of $3.7 \pm 1.0$ events. Restricting the phase space to only include $\Lambda$ baryons that decay above MicroBooNE's detection thresholds, we obtain a flux averaged cross section of $2.0^{+2.2}_{-1.7} \times 10^{-40}$ cm$^2/$Ar, where statistical and systematic uncertainties are combined

New CC0\pi\ GENIE Model Tune for MicroBooNE

A novel tune has been made for the MicroBooNE experiment. The fit uses 4 new parameters within the GENIE v3.0.6 Monte Carlo program. Charged current pionless data from the T2K experiment was used. New uncertainties were obtained. These results will be used in future MicroBooNE analyses.Comment: 24 pages, 14 figure

Search for heavy neutral leptons in electron-positron and neutral-pion final states with the MicroBooNE detector

We present the first search for heavy neutral leptons (HNL) decaying into $\nu e^+e^-$ or $\nu\pi^0$ final states in a liquid-argon time projection chamber using data collected with the MicroBooNE detector. The data were recorded synchronously with the NuMI neutrino beam from Fermilab's Main Injector corresponding to a total exposure of $7.01 \times 10^{20}$ protons on target. We set upper limits at the $90\%$ confidence level on the mixing parameter $\lvert U_{\mu 4}\rvert^2$ in the mass ranges $10\le m_{\rm HNL}\le 150$ MeV for the $\nu e^+e^-$ channel and $150\le m_{\rm HNL}\le 245$ MeV for the $\nu\pi^0$ channel, assuming $\lvert U_{e 4}\rvert^2 = \lvert U_{\tau 4}\rvert^2 = 0$. These limits represent the most stringent constraints in the mass range $35<m_{\rm HNL}<175$ MeV and the first constraints from a direct search for $\nu\pi^0$ decays.Comment: Version as accepted by Physical Review Letters, some presentational changes and updated references, no changes to result

First demonstration of O(1 ns)\mathcal{O}(1\,\text{ns}) timing resolution in the MicroBooNE liquid argon time projection chamber

MicroBooNE is a neutrino experiment located in the Booster Neutrino Beamline (BNB) at Fermilab, which collected data from 2015 to 2021. MicroBooNE's liquid argon time projection chamber (LArTPC) is accompanied by a photon detection system consisting of 32 photomultiplier tubes used to measure the argon scintillation light and determine the timing of neutrino interactions. Analysis techniques combining light signals and reconstructed tracks are applied to achieve a neutrino interaction time resolution of $\mathcal{O}(1\,\text{ns})$. The result obtained allows MicroBooNE to access the ns neutrino pulse structure of the BNB for the first time. The timing resolution achieved will enable significant enhancement of cosmic background rejection for all neutrino analyses. Furthermore, the ns timing resolution opens new avenues to search for long-lived-particles such as heavy neutral leptons in MicroBooNE, as well as in future large LArTPC experiments, namely the SBN program and DUNE

First Measurement of Differential Charged Current Quasielasticlike νμ-Argon Scattering Cross Sections with the MicroBooNE Detector

We report on the first measurement of flux-integrated single differential cross sections for chargedcurrent (CC) muon neutrino (νμ) scattering on argon with a muon and a proton in the final state, 40Ar ðνμ; μpÞX. The measurement was carried out using the Booster Neutrino Beam at Fermi National Accelerator Laboratory and the MicroBooNE liquid argon time projection chamber detector with an exposure of 4.59 × 1019 protons on target. Events are selected to enhance the contribution of CC quasielastic (CCQE) interactions. The data are reported in terms of a total cross section as well as single differential cross sections in final state muon and proton kinematics.We measure the integrated per-nucleus CCQE-like cross section (i.e., for interactions leading to a muon, one proton, and no pions above detection threshold) of ð4.93 0.76stat 1.29sysÞ × 10−38 cm2, in good agreement with theoretical calculations. The single differential cross sections are also in overall good agreement with theoretical predictions, except at very forward muon scattering angles that correspond to low-momentum-transfer events.United States Department of Energy (DOE)National Science Foundation (NSF)Swiss National Science Foundation (SNSF)Science and Technology Facilities Council (STFC), part of the United Kingdom Research and InnovationRoyal Society of LondonAlbert Einstein Center for Fundamental Physics, Bern, SwitzerlandAzrieli FoundationZuckerman STEM Leadership ProgramIsrael Science FoundationVisiting Scholars Award Program of the Universities Research AssociationDE-AC02-07CH1135

First Measurement of Differential Cross Sections for Muon Neutrino Charged Current Interactions on Argon with a Two-proton Final State in the MicroBooNE Detector

We present the first measurement of differential cross sections for charged-current muon neutrino interactions on argon with one muon, two protons, and no pions in the final state. Such interactions leave the target nucleus in a two-particle two-hole state; these states are of great interest, but currently there is limited information about their production in neutrino-nucleus interactions. Detailed investigations of the production of two-particle two-hole states are vital to support upcoming experiments exploring the nature of the neutrino, and the development of the liquid-argon time-projection-chamber has made possible the isolation of such final states. The opening angle between the two protons, the angle between the total proton momentum and the muon, and the total transverse momentum of the final state system are sensitive to the underlying physics processes as embodied in a variety of models. Realistic initial-state momentum distributions are shown to be important in reproducing the data.Comment: To be submitted to PR