Detection and measurement of Hypercholesterolaemia in South Africans attending general practitioners in private practice - The cholesterol monitor

Background. 1bis paper reports data on the detection and management of hypercholesterolaemia in patients attending general practitioners in private practice in South Africa.Methods. The frequency of cholesterol testing and the level at which active therapeutic intervention occurred at medical practices were monitored over a 2-year period. A sample of 200 medical practitioners was selected from private practices in major citie;. Data on patients seen by the selected doctors during a 5-day monitoring period were recorded on a standardised form.Results. 12842 patients were seen by the 200 private practice· GPs. More men (18.7%) than women (10.4%) had coronary heart disease (CHD), and their mean total cholesterol (TC) levels were 5.9 mmol/l and 6.0 mmol/l, respectively. Only 3.1% of the patients were reported to have familial hypercholesterolaemia (FH) and 12.8% were reported to have a family history of CHD. Reported smoking rates were exceptionally high (77.5% of women and 64.4% of men). The most commonly prescribed group of lipid-lowering agents was HMG-CoA reductase inhibitors.Conclusions. Inadequate management of hypercholesterol-· aemia leaves many patients with a high risk of CHD mortality in South Africa. Appropriately investigated patients with hypercholesterolaemia should receive treatment to reduce cardiovascular disease using more effective TC control programmes than are currently used in South Africa

AN INVESTIGATION INTO THE UTILISATION OF SOCIAL MEDIA TO FOSTER TEAM COLLABORATION IN A HIGHER EDUCATION INSTITUTION

The COVID-19 pandemic introduced new challenges with subsequent opportunities to teach innovative ways of team collaboration. One example is the utilisation of social media to foster online team collaboration. This study investigates the use of Discord by students, a social media platform originally developed for online gamers, to collaborate virtually to complete project team tasks. The research question – what role a social media tool, namely Discord, plays in fostering team collaboration – was investigated using a qualitative, interpretative approach. Topic modeling identified ten themes, with the most vital theme indicating that students initially used Discord due to the academic requirement but later extensively used the platform because of its convenience and usefulness. Most students continued to use Discord even after completing their studies. While the main reason for adopting the tool was convenience due to peers using the platform, it became a logical and practical platform to communicate with friends, work on completing tasks together, and as a result, create a strong sense of belonging

Municipal sludge as source of nitrogen and phosphorus in perennial pasture Eragrostis curvula production: Agronomic benefits and environmental impacts

Land application of sludge has been shown to improve soil properties and aid crop growth, but the possibility of constituent nutrients such as nitrogen and phosphorus reaching environmentally toxic levels has caused governing authorities to set limits to how much sludge can be applied to agronomic land. The high nitrogen utilisation potential of pasture grasses suggests that more sludge can be used in this cropping system without the risk of excess nitrates. This study investigates the effect of exceeding the South African sludge application limit on hay yield, soil nitrates and phosphorus. Field plots were arranged in a complete block design comprising 4 replications of 4 treatments planted to Eragrostis curvula. The treatments consisted of 0, 4, 8 and 16 Mg∙ha-1 anaerobically digested sludge. Soil samples were collected before treatment application and at the end of each growing season for N, P, NO3-, NH4+, and Bray-1P analyses. Plant samples were collected at flowering stage for hay yield and N and P uptake determination. Statistical analyses were conducted using analysis of variance (ANOVA) and general linear model (GLM) procedures of Windows SAS 9.0 to evaluate the effect of sludge application rates on hay yield. Results over 4 growing seasons indicate that exceeding the recommended limit increased hay yield by 4% in a dry season (11.7 vs. 12.36 Mg∙ha-1) and by 16% in a wet season (14.19 vs. 17.31 Mg∙ha-1) and also increased nitrogen uptake by 15%. Sludge applied at double the recommended limit did not cause the accumulation of nitrate and ammonium in the soil, however, both total and Bray-1P were doubled. The study shows that the potential long-term environmental risk of doubling the sludge application rate norm would be from labile P accumulation in the soil profile despite a sludge P:Fe molar ratio of less than unity.Keywords: sludge, Eragrostis curvula, nitrogen, phosphorus, leachin

Comparison of methods for determining unsaturated hydraulic conductivity in the wet range to evaluate the sensitivity of wetting front detectors

The design of passive lysimeters or wetting front detectors determines the tensions at which they collect a water sample from an unsaturated soil. When deployed in the field to help manage irrigation, it is necessary to know the minimum flux of water that can be sampled by a passive lysimeter and how this relates to the drainage flux at field capacity. This requires a good estimate of the unsaturated hydraulic conductivity characteristic, K(h), in the wet range (< 10 kPa). We compared various field, laboratory and theoretical approaches for obtaining the K(h) function and compared these to a reference K(h) function derived by applying inverse modelling approaches to field drainage experimental data. The Van Genuchten model and three of the pedotransfer models produced K(h) functions with a root mean square error of less than 5% compared to the reference, and appear to be simple methods of obtaining a reasonable estimate of unsaturated hydraulic conductivity. However, despite the goodness of fit, there can be a 10-fold difference in conductivity at a given tension < 10 kPa estimated from the different methods. Moreover, water content at field capacity depends entirely on whether field capacity is defined as time elapsed after saturation, a set tension or a minimum flux.Keywords: inverse modelling, instantaneous profile method, pedotransfer functions, wetting front detector, field capacity, HYDRUS-2

A preliminary investigation of the water use efficiency of sweet sorghum for biofuel in South Africa

Sweet sorghum (Sorghum bicolor (L.) Moench) has been recognized globally as a potential biofuel crop for ethanol production. Sweet sorghum is a drought-tolerant crop that is widely adapted to different environmental growing conditions. The aim of this study was to determine the water use efficiency (utilisable yield per unit amount of water used) of drip-irrigated sweet sorghum (variety Sugargraze) under two different climatic conditions in South Africa. The sweet sorghum trials were conducted at Ukulinga research farm (University of KwaZulu-Natal, Pietermaritzburg) and Hatfield experimental farm (University of Pretoria, Pretoria), South Africa. Field trials were conducted in two successive seasons, viz., 2010/11 and 2011/12. Seasonal water use was estimated using eddy covariance and surface renewal methods. Fresh and dry aboveground biomass yield, stalk yield and stalk Brix % were measured at final harvest. Theoretical ethanol yield was calculated from fresh stalk yield and Brix %. Water use for the two growing seasons was 415 mm at Ukulinga and 398 mm at Hatfield. The ethanol water use efficiency (WUE) values for the sweet sorghum at Ukulinga were 0.27 and 0.60 L∙m-3 for 2010/11 and 2011/12 growing seasons, respectively. The ethanol WUE estimate of the sweet sorghum at Hatfield was 0.53 L∙m-3 for the 2010/11 season and 0.70 L∙m-3 for the 2011/12 growing season. WUE estimates of the sweet sorghum crop were higher for Hatfield compared to Ukulinga research farm. The results from this study showed that the WUE of sweet sorghum was sensitive to plant density. The WUE values confirm that sweet sorghum has high WUE under different climatic conditions.Keywords: water use efficiency; ethanol yield; biofuel crop; plant density, sweet sorghum, South Afric

The association between nutrition and physical activity knowledge and weight status of primary school educators

The purpose of this study was to investigate primary school educators’ health status, knowledge, perceptions and behaviour regarding nutrition and physical activity.Thus, nutrition and physical activity knowledge, attitudes,  behaviour and risk factors for the development of non-communicable diseases of 155 educators were assessed in a  cross-sectional survey. Height, weight, waist circumference, blood pressure and random glucose levels were  measured. Twenty percent of the sample had normal weight (body mass index (BMI, kg/m²) &lt; 25), 27.7% were  overweight (BMI 25 to < 30) and 52.3% were obese (BMI < 30). Most of the participants were younger than 45  years (54.2%), females 78.1%, resided in urban areas (50.3%), with high blood pressure ( 140/90 mmHg:  50.3%), and were inactive (48.7%) with a high waist circumference (&gt; 82 cm: 57.4%). Educators’ nutrition and  physical activity knowledge was poor. Sixty-nine percent of educators incorrectly believed that eating starchy foods  causes weight gain and only 15% knew that one should eat five or more fruit and/or vegetables per day. Aspects of poor nutritional knowledge, misconceptions regarding actual body weight status, and challenges in changing health behaviours, emerged as issues which need to be addressed among educators. Educators’ high risk for developing chronic non-communicable diseases (NCDs) may impact on educator absenteeism and subsequently on school  functioning. The aspects of poor nutrition and physical activity knowledge along with educators’ high risk for NCD development may be particularly significant not merely in relation to their personal health but also the learners they teach.Keywords: body weight, educators, health, knowledge, non-communicable diseases, nutrition, perceptions, physical activity, primary schools, risk factor

Prediction of the environmental impact and sustainability of large-scale irrigation with gypsiferous mine-water on groundwater resources

Irrigation of agricultural crops is one of the most cost-effective options for the utilisation of gypsiferous mine wastewater. In addition, it creates the opportunity to produce crops during the dry season. Gypsum is a slightly soluble salt and concentrating the gypsiferous soil solution through crop evapotranspiration precipitates gypsum in the soil profile, removing it from the water system and reducing the potential for groundwater pollution. In previous research, it was found that crops can be commercially produced under irrigation with gypsiferous mine- water with no obvious impact on groundwater in the short term (3 years). It was, however, recommended that monitoring should continue to confirm findings over a longer period and for different conditions. A research project was therefore initiated in 2001 to determine the impact of  irrigation with several gypsiferous water/soil combinations on crop performance, soil properties and groundwater quality. Field trials were carried out in South Africa on three mines: Kleinkopjé and New Vaal Collieries (Anglo Coal), and at Syferfontein (Sasol). Different crop and pasture species were grown on different soil types under centre-pivot irrigation with different mine-water qualities. Intensive monitoring systems were established in each irrigated field to determine the components of the soil-water and salt balance. Boreholes were also installed to monitor groundwater level and quality. Field water and salt balance data were used for calibration and validation of the mechanistic, generic crop, Soil-Water Balance (SWB) Model. The results of the field trials indicated that high crop and pasture yields can be obtained, provided site selection, land preparation, fertilisation and irrigation water management are appropriate. The results of the soil-water and salt balance studies indicated that considerable volumes of mine-water can be used and substantial amounts of salts can be removed from the water system through precipitation of gypsum in the soil profile. The groundwater impact was limited based on borehole measurements, indicating the presence of a zone of attenuation between the cropped soil profile and groundwater, but this should be monitored over a longer period. With appropriate management, water and salt runoff, and under specific conditions, drainage and salts leached can be intercepted, thereby minimising unwanted impacts on groundwater. Thirty-year scenario simulations were run with SWB and the generated salt loads from this model were used as input into a separate groundwater model in order to predict the likely long-term effects of irrigation with gypsiferous mine-water on groundwater. The results of these simulations showed that while salts reached the groundwater, there was a drop in concentration of the plume as it moved away from the irrigated area. This was due largely to dilution by infiltration from rainfall recharge and the dispersive characteristics of the aquifer. The simulations also showed the importance of matching the amount of drainage from an irrigated site with the transmissivity and storage properties of the aquifer below. These results suggest that large-scale irrigation with gypsiferous water could be viable if irrigated fields are carefully sited to prevent waterlogging and are well managed. A site-specific approach is essential. Water SA Vol 32(1)pp:21-2

Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer

Chiral, dimeric natural products containing complex structures and interesting biological properties have inspired chemists and biologists for decades. A seven-step total synthesis of the axially chiral, dimeric tetrahydroxanthone natural product rugulotrosin A is described. The synthesis employs a one-pot Suzuki coupling/dimerization to generate the requisite 2,2'-biaryl linkage. Highly selective point-to-axial chirality transfer was achieved using palladium catalysis with achiral phosphine ligands. Single X-ray crystal diffraction data were obtained to confirm both the atropisomeric configuration and absolute stereochemistry of rugulotrosin A. Computational studies are described to rationalize the atropselectivity observed in the key dimerization step. Comparison of the crude fungal extract with synthetic rugulotrosin A and its atropisomer verified that nature generates a single atropisomer of the natural product.P50 GM067041 - NIGMS NIH HHS; R01 GM099920 - NIGMS NIH HHS; GM-067041 - NIGMS NIH HHS; GM-099920 - NIGMS NIH HH

Efficiency of immediate postoperative inpatient physical therapy following total knee arthroplasty: an RCT

BACKGROUND: The main goal of physical therapy treatment (PT) in the clinical stage following total knee arthroplasty (TKA) is to prepare patients for discharge from the hospital as soon as possible after their operation. Although aggressive rehabilitation is believed to be important, evidence of effects of different exercise programmes following TKA is limited. This led to the question whether the intensity of PT (once versus twice daily) following TKA affects short-term recovery, measured as range of motion. METHODS: A randomised controlled trial compared an exercise regimen of two sessions per day with a similar programme administered once daily. Primary outcome measure was ROM. RESULTS: At the time of hospital discharge, there was no difference between the experimental and control groups in range of motion. CONCLUSION: This study shows that in our setting twice daily PT sessions do not produce different results as daily PT sessions. It may be questioned whether multiple daily therapy sessions are needed as an in-hospital PT regimen in OA total knee patients

The significance of the sense of coherence for various coping resources in stress situations used by police officers in on-the-beat service

Background: Police officers meet many stressors as part of their occupation. The psychological resource "sense of coherence" (SOC) protects against ill-health, but its impact on coping resources for stress situations has not been studied in the population of police officers. Different approaches to investigate the significance of SOC for different outcomes have been identified in literature, leading to some difficulties in the interpretation and generalization of results. The aim was therefore to explore SOC and the coping resources, and to examine the significance of SOC for various coping resources for stress using different models in a sample of Swedish police officers providing on-the-beat service. Materials and Methods: One hundred and one police officers (age: mean = 33 years, SD = 8; 29 females) were included, and the Orientation to Life Questionnaire (SOC-29) and the Coping Resources Inventory (CRI) were used. The dependent variable in each regression analysis was one of the coping resources: cognitive, social, emotional, spiritual/philosophical, physical, and a global resource. Global SOC-29 and/or its components (comprehensibility, manageability, and meaningfulness) were investigated as independent variables. Results: All CRI and SOC-29 scores except for that of spiritual/philosophical resources were higher than those of reference groups. Manageability was the most important component of SOC for various coping resources in stress situations used by police officers. Conclusion: A deeper study of manageability will give useful information, because this component of SOC is particularly significant in the variation in resources used by police officers to cope with stress. Salutogenesis, the origin of well-being, should be more in focus of future research on workplaces with a high level of occupational stress