Validation of Health Behavior and Stages of Change Questionnaire

Leivy Patricia Gonzalez-Ramirez,1,2 Jose Maria De la Roca-Chiapas,2 Cecilia Colunga-Rodriguez,3,4 Maria de Lourdes Preciado-Serrano,3 Adrian Daneri-Navarro,5 Francisco Javier Pedroza-Cabrera,6 Reyna Jazmin Martinez-Arriaga1 1Department of Health Sciences, University Centre of Tonala, University of Guadalajara, Guadalajara, 2Department of Psychology, Division of Health Sciences, Campus Leon, University of Guanajuato, Guanajuato, 3Department of Public Health, University Centre for Health Sciences, University of Guadalajara, 4Paediatric Hospital, Western National Medical Centre, Mexican Social Security Institute, 5Departament of Physiology, University Centre for Health Sciences, University of Guadalajara, Guadalajara, 6Department of Psychology, Autonomous University of Aguascalientes, Aguascalientes, Mexico Background: The transtheoretical model (TTM) has been widely used to promote healthy behaviors in different groups. However, a questionnaire has not yet been developed to evaluate the health behaviors that medical practitioners often consider in individuals with cancer or at a high risk of developing cancer.Purpose: The aim of this study was to construct and validate the Health Behavior and Stages of Change Questionnaire (HBSCQ), which is based on the TTM and health recommendations related to risk and factors that protect against cancer. Methods: Content validity was conducted in two phases (qualitative and quantitative). Item difficulty index, item discrimination index, and discrimination coefficient were obtained based on the classical test theory. Finally, Cronbach’s alpha was used.Results: Measure of concordance showed scores considered adequate and excellent. The item discrimination index obtained a rating of “excellent” and suggested the preservation of all items. The discrimination coefficient scores are >0.74. The global internal consistency of the HBSCQ was 0.384. HBSCQ specification between groups of internal consistency for the sample of men was 0.712 and that for the sample of women was 0.378. Conclusion/implications for practice: The HBSCQ represents a proposal for a fast, simple, and innovative screening test, which aims to identify persons who may benefit from interventions to promote health behaviors delimited to the stage of change. Keywords: screening tests, health promotion, lifestyle, transtheoretical mode

Impact of stress and levels of corticosterone on the development of breast cancer in rats

José María De la Roca-Chiapas,1 Gloria Barbosa-Sabanero,2 Jorge Antonio Martínez-García,3 Joel Martínez-Soto,1 Víctor Manuel Ramos-Frausto,1 Leivy Patricia González-Ramírez,1 Ken Nowack4 1Department of Psychology, 2Department of Medical Sciences, Division of Health Sciences, Campus Leon-University of Guanajuato, Guanajuato, 3General Regional Hospital of Leon, Guanajuato, Mexico; 4Envisia Learning, Inc., Santa Monica, CA, USA Abstract: Stress is experienced during cancer, and impairs the immune system's ability to protect the body. Our aim was to investigate if isolation stress has an impact on the development of tumors in rats, and to measure the size and number of tumors and the levels of corticosterone. Breast cancer was induced in two groups of female rats (N=20) by administration of a single dose of N-methyl-N-nitrosourea 50 mg/kg. Rats in the control group (cancer induction condition) were allowed to remain together in a large cage, whereas in the second group, rats were also exposed to a stressful condition, that is, isolation (cancer induction and isolation condition, CIIC). The CIIC group displayed anxious behavior after 10 weeks of isolation. In the CIIC group, 16 tumors developed, compared with only eleven tumors in the control cancer induction condition group. In addition, compared with the control group, the volume of tumors in the CIIC group was greater, and more rats had more than one tumor and cells showed greater morphological damage. Levels of corticosterone were also significantly different between the two groups. This study supports the hypothesis that stress can influence the development of cancer, but that stress itself is not a sufficient factor for the development of cancer in rats. The study also provides new information for development of experimental studies and controlled environments. Keywords: breast cancer, corticosterone, isolation condition, psychoneuroimmunology, stres

Association Between Telomere Length and C-Reactive Protein and the Development of Coronary Collateral Circulation in Patients with Coronary Artery Disease

The Science and Technology Council of Guanajuato State (CONCYTEG) [08-38-K662-131]; Health Research Fund [FIS/IMSS/PROT/083