How Firms Adapt and Interact in Open Source Ecosystems: Analyzing Stakeholder Influence and Collaboration Patterns

[Context and motivation] Ecosystems developed as Open Source Software (OSS) are considered to be highly innovative and reactive to new market trends due to their openness and wide-ranging contributor base. Participation in OSS often implies opening up of the software development process and exposure towards new stakeholders. [Question/Problem] Firms considering to engage in such an environment should carefully consider potential opportunities and challenges upfront. The openness may lead to higher innovation potential but also to frictional losses for engaged firms. Further, as an ecosystem progresses, power structures and influence on feature selection may fluctuate accordingly. [Principal ideas/results] We analyze the Apache Hadoop ecosystem in a quantitative longitudinal case study to investigate changing stakeholder influence and collaboration patterns. Further, we investigate how its innovation and time-to-market evolve at the same time. [Contribution] Findings show collaborations between and influence shifting among rivaling and non-competing firms. Network analysis proves valuable on how an awareness of past, present and emerging stakeholders, in regards to power structure and collaborations may be created. Furthermore, the ecosystem’s innovation and time-to-market show strong variations among the release history. Indications were also found that these characteristics are influenced by the way how stakeholders collaborate with each other

3, 3′5 Triiodo L Thyronine Induces Apoptosis in Human Breast Cancer MCF-7cells, Repressing SMP30 Expression through Negative Thyroid Response Elements

Thyroid hormones regulate cell proliferation, differentiation as well as apoptosis. However molecular mechanism underlying apoptosis as a result of thyroid hormone signaling is poorly understood. The antiapoptotic role of Senescence Marker Protein-30 (SMP30) has been characterized in response to varieties of stimuli as well as in knock out model. Our earlier data suggest that thyroid hormone 3, 3'5 Triiodo L Thyronine (T(3)), represses SMP30 in rat liver.In highly metastatic MCF-7, human breast cancer cell line T3 treatment repressed SMP30 expression leading to enhanced apoptosis. Analysis by flow cytometry and other techniques revealed that overexpression and silencing of SMP30 in MCF-7 resulted in decelerated and accelerated apoptosis respectively. In order to identify the cis-acting elements involved in this regulation, we have analyzed hormone responsiveness of transiently transfected hSMP30 promoter deletion reporter vectors in MCF-7 cells. As opposed to the expected epigenetic outcome, thyroid hormone down regulated hSMP30 promoter activity despite enhanced recruitment of acetylated H3 on thyroid response elements (TREs). From the stand point of established epigenetic concept we have categorised these two TREs as negative response elements. Our attempt of siRNA mediated silencing of TRβ, reduced the fold of repression of SMP30 gene expression. In presence of thyroid hormone, Trichostatin- A (TSA), which is a Histone deacetylase (HDAC) inhibitor further inhibited SMP30 promoter activity. The above findings are in support of categorisation of both the thyroid response element as negative response elements as usually TSA should have reversed the repressions.This is the first report of novel mechanistic insights into the remarkable downregulation of SMP30 gene expression by thyroid hormone which in turn induces apoptosis in MCF-7 human breast cancer cells. We believe that our study represents a good ground for future effort to develop new therapeutic approaches to challenge the progression of breast cancer

Developer Dynamics and Syntactic Quality of Commit Messages in OSS Projects

Part 2: OSS Projects ValidityInternational audienceCommunity dynamics play an important role in the Open Source Software (OSS) development paradigm. Researchers have extensively studied the human aspects of the OSS paradigm from the point of view of community formation to community evolution. A few studies relate community dynamics with OSS product attributes such as code quality. However, the impact of community dynamics on non-code contributions such as commits has not been explored. In this paper, the aim is to analyze the impact of community dynamics on syntactic quality of commit messages of an OSS project. We first propose and validate a commit message quality model, and then use that model to analyze the OSS projects. Empirical analysis of seven OSS projects available in the Git repository shows that a small group of contributors active at the same time in a project leads to high syntactic quality contributions. These observations may prove useful to developers as well as project managers who need quantifiable techniques for monitoring the OSS projects

In vivo evidence of mitochondrial dysfunction and altered redox homeostasis in a genetic mouse model of propionic acidemia: Implications for the pathophysiology of this disorder.

Accumulation of toxic metabolites has been described to inhibit mitochondrial enzymes, thereby inducing oxidative stress in propionic acidemia (PA), an autosomal recessive metabolic disorder caused by the deficiency of mitochondrial propionyl-CoA carboxylase. PA patients exhibit neurological deficits and multiorgan complications including cardiomyopathy. To investigate the role of mitochondrial dysfunction in the development of these alterations we have used a hypomorphic mouse model of PA that mimics the biochemical and clinical hallmarks of the disease. We have studied the tissue-specific bioenergetic signature by Reverse Phase Protein Microarrays and analysed OXPHOS complex activities, mtDNA copy number, oxidative damage, superoxide anion and hydrogen peroxide levels. The results show decreased levels and/or activity of several OXPHOS complexes in different tissues of PA mice. An increase in mitochondrial mass and OXPHOS complexes was observed in brain, possibly reflecting a compensatory mechanism including metabolic reprogramming. mtDNA depletion was present in most tissues analysed. Antioxidant enzymes were also found altered. Lipid peroxidation was present along with an increase in hydrogen peroxide and superoxide anion production. These data support the hypothesis that oxidative damage may contribute to the pathophysiology of PA, opening new avenues in the identification of therapeutic targets and paving the way for in vivo evaluation of compounds targeting mitochondrial biogenesis or reactive oxygen species production

Setting Up Government 3.0 Solutions Based on Open Source Software: The Case of X-Road

Part 2: E-Government Services and Open GovernmentInternational audienceGovernment 3.0, which builds on openness and transparency, sharing, increased communication and collaboration, government reorganization through integration and interoperability, and use of new technologies, is an emerging concept in eGovernance. However, few systems that qualify as Government 3.0 have been described in detail so far. And there is a lack of research on how governments can put in place such systems. This study investigates and characterizes an innovative eGovernment project, based on Open Source Software (OSS), that could be considered as an example of a Government 3.0 project. Therefore, we report from a case study of X-Road, an originally Estonian eGovernment project for creating a data sharing infrastructure, which today is also used in other countries. We present the main characteristics of X-Road from the point of view of Government 3.0, how the X-Road project is organized, compare its organization to other OSS projects, identify who contributes to the project, and point out what challenges are perceived by their stakeholders. We conclude offering some reflections on how X-Road and other Government 3.0 projects can benefit from OSS

Open Innovation through the Lens of Open Source Tools: A case study at Sony Mobile

Despite growing interest of Open Innovation (OI) in Software Engineering (SE), little is known about what triggers software organizations to adopt it and how this affects SE practices. OI can be realized in numerous of ways, including Open Source Software (OSS) involvement. Outcomes from OI are not restricted to product innovation but also include process innovation, e.g. improved SE practices and methods. This study explores the involvement of a software organization (Sony Mobile) in OSS communities from an OI perspective and what SE practices (requirements engineering and testing) have been adapted in relation to OI. It also highlights the innovative outcomes resulting from OI. An exploratory embedded case study investigates how Sony Mobile use and contribute to Jenkins and Gerrit; the two central OSS tools in their continuous integration tool chain. Quantitative analysis was performed on change log data from source code repositories in order to identify the top contributors and triangulated with the results from five semi-structured interviews to explore the nature of the commits. The findings of the case study include five major themes: i) The process of opening up towards the tool communities correlates in time with a general adoption of OSS in the organization. ii) Assets not seen as competitive advantage nor a source of revenue are made open to OSS communities, and gradually, the organization turns more open. iii) The requirements engineering process towards the community is informal and based on engagement. iv) The need for systematic and automated testing is still in its infancy, but the needs are identified. v) The innovation outcomes included free features and maintenance, and were believed to increase speed and quality in development. Adopting OI was a result of a paradigm shift of moving from Windows to Linux. This shift enabled Sony Mobile to utilize the Jenkins and Gerrit communities to make their internal development process better for its software developers and testers.open access</p