362 research outputs found
Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic inflammation in patients with knee osteoarthritis? A systematic review and meta-analysis
Objectives We systemically reviewed published studies that evaluated aerobic exercise interventions in patients with knee osteoarthritis (OA) to: (1) report the frequency, intensity, type and time (FITT) of exercise prescriptions and (2) quantify the changes in markers of cardiovascular health and systemic inflammation. Data sources PubMed, CINAHL, Scopus; inception to January 2019. Eligibility criteria Randomised clinical trials (RCT), cohort studies, case series. Design We summarised exercise prescriptions for all studies and calculated effect sizes with 95% CIs for between-group (RCTs that compared exercise and control groups) and within-group (pre-post exercise) differences in aerobic capacity (VO2), heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and inflammatory markers (interleukin-6 (IL-6), tumour necrosis factor-alpha). We pooled results where possible using random effects models. Results Interventions from 49 studies were summarised; 8% (4/49) met all FITT guidelines; 16% (8/49) met all or most FITT guidelines. Fourteen studies (10 RCTs) reported at least one marker of cardiovascular health or systemic inflammation. Mean differences (95% CI) indicated a small to moderate increase in VO2(0.84 mL/min/kg; 95% CI 0.37 to 1.31), decrease in HR (-3.56 beats per minute; 95% CI -5.60 to -1.52) and DBP (-4.10 mm Hg; 95% CI -4.82 to -3.38) and no change in SBP (-0.36 mm Hg; 95% CI -3.88 to 3.16) and IL-6 (0.37 pg/mL; 95% CI -0.11 to 0.85). Within-group differences were also small to moderate. Conclusions In studies of aerobic exercise in patients with knee OA, very few interventions met guideline-recommended dose; there were small to moderate changes in markers of cardiovascular health and no decrease in markers of systemic inflammation. These findings question whether aerobic exercise is being used to its full potential in patients with knee OA. PROSPERO registration number CRD42018087859
symmetry and quasi-normal modes in the BTZ black hole
With the help of two new intrinsic tensor fields associated with the
quadratic Casimir of Killing fields, we uncover the
symmetry satisfied by the solutions to the equations of motion for various
fields in the BTZ black hole in a uniform way by performing tensor and spinor
analysis without resorting to any specific coordinate system. Then with the
standard algebraic method developed recently, we determine the quasi-normal
modes for various fields in the BTZ black hole. As a result, the quasi-normal
modes are given by the infinite tower of descendants of the chiral highest
weight mode, which is in good agreement with the previous analytic result
obtained by exactly solving equations of motion instead.Comment: JHEP style, 1+13 pages, version to appear in JHE
Higher spin quasinormal modes and one-loop determinants in the BTZ black hole
We solve the wave equations of arbitrary integer spin fields in the BTZ black
hole background and obtain exact expressions for their quasinormal modes. We
show that these quasinormal modes precisely agree with the location of the
poles of the corresponding two point function in the dual conformal field
theory as predicted by the AdS/CFT correspondence. We then use these
quasinormal modes to construct the one-loop determinant of the higher spin
field in the thermal BTZ background. This is shown to agree with that obtained
from the corresponding heat kernel constructed recently by group theoretic
methods.Comment: 47 page
The Sound of Topology in the AdS/CFT Correspondence
Using the gauge/gravity correspondence, we study the properties of 2-point
correlation functions of finite-temperature strongly coupled gauge field
theories, defined on a curved space of general spatial topology with a dual
black hole description. We derive approximate asymptotic expressions for the
correlation functions and their poles, supported by exact numerical
calculations, and study their dependence on the dimension of spacetime and the
spatial topology. The asymptotic structure of the correlation functions depends
on the relation between the spatial curvature and the temperature, and is
noticeable when they are of the same order. In the case of a hyperbolic
topology, a specific temperature is identified for which exact analytical
solutions exist for all types of perturbations. The asymptotic structure of the
correlation functions poles is found to behave in a non-smooth manner when
approaching this temperature.Comment: 65 pages, LaTeX, 21 figures, 1 table; fixed a small error in
subsection 3.
Higher spin fermions in the BTZ black hole
Recently it has been shown that the wave equations of bosonic higher spin
fields in the BTZ background can be solved exactly. In this work we extend this
analysis to fermionic higher spin fields. We solve the wave equations for
arbitrary half-integer spin fields in the BTZ black hole background and obtain
exact expressions for their quasinormal modes. These quasinormal modes are
shown to agree precisely with the poles of the corresponding two point function
in the dual conformal field theory as predicted by the AdS/CFT correspondence.
We also obtain an expression for the 1-loop determinant in terms of the
quasinormal modes and show it agrees with that obtained by integrating the heat
kernel found by group theoretic methods.Comment: 29 page
Social interactions through the eyes of macaques and humans
Group-living primates frequently interact with each other to maintain social bonds as well as to compete for valuable resources. Observing such social interactions between group members provides individuals with essential information (e.g. on the fighting ability or altruistic attitude of group companions) to guide their social tactics and choice of social partners. This process requires individuals to selectively attend to the most informative content within a social scene. It is unclear how non-human primates allocate attention to social interactions in different contexts, and whether they share similar patterns of social attention to humans. Here we compared the gaze behaviour of rhesus macaques and humans when free-viewing the same set of naturalistic images. The images contained positive or negative social interactions between two conspecifics of different phylogenetic distance from the observer; i.e. affiliation or aggression exchanged by two humans, rhesus macaques, Barbary macaques, baboons or lions. Monkeys directed a variable amount of gaze at the two conspecific individuals in the images according to their roles in the interaction (i.e. giver or receiver of affiliation/aggression). Their gaze distribution to non-conspecific individuals was systematically varied according to the viewed species and the nature of interactions, suggesting a contribution of both prior experience and innate bias in guiding social attention. Furthermore, the monkeys’ gaze behavior was qualitatively similar to that of humans, especially when viewing negative interactions. Detailed analysis revealed that both species directed more gaze at the face than the body region when inspecting individuals, and attended more to the body region in negative than in positive social interactions. Our study suggests that monkeys and humans share a similar pattern of role-sensitive, species- and context-dependent social attention, implying a homologous cognitive mechanism of social attention between rhesus macaques and humans
Chern-Simons black holes: scalar perturbations, mass and area spectrum and greybody factors
We study the Chern-Simons black holes in d-dimensions and we calculate
analytically the quasi-normal modes of the scalar perturbations and we show
that they depend on the highest power of curvature present in the Chern-Simons
theory. We obtain the mass and area spectrum of these black holes and we show
that they have a strong dependence on the topology of the transverse space and
they are not evenly spaced. We also calculate analytically the reflection and
transmission coefficients and the absorption cross section and we show that at
low frequency limit there is a range of modes which contributes to the
absorption cross section.Comment: 19 pages, 18 figures, the title has been changed to reflect the
addition of an another section on the reflection, transmission coefficients
and absorption cross sections of the Chern-Simons black holes. Version to be
published in JHE
CR1 Knops blood group alleles are not associated with severe malaria in the Gambia
The Knops blood group antigen erythrocyte polymorphisms have been associated with reduced falciparum malaria-based in vitro rosette formation (putative malaria virulence factor). Having previously identified single-nucleotide polymorphisms (SNPs) in the human complement receptor 1 (CR1/CD35) gene underlying the Knops antithetical antigens Sl1/Sl2 and McC(a)/McC(b), we have now performed genotype comparisons to test associations between these two molecular variants and severe malaria in West African children living in the Gambia. While SNPs associated with Sl:2 and McC(b+) were equally distributed among malaria-infected children with severe malaria and control children not infected with malaria parasites, high allele frequencies for Sl 2 (0.800, 1,365/1,706) and McC(b) (0.385, 658/1706) were observed. Further, when compared to the Sl 1/McC(a) allele observed in all populations, the African Sl 2/McC(b) allele appears to have evolved as a result of positive selection (modified Nei-Gojobori test Ka-Ks/s.e.=1.77, P-value <0.05). Given the role of CR1 in host defense, our findings suggest that Sl 2 and McC(b) have arisen to confer a selective advantage against infectious disease that, in view of these case-control study data, was not solely Plasmodium falciparum malaria. Factors underlying the lack of association between Sl 2 and McC(b) with severe malaria may involve variation in CR1 expression levels
Incompressible Fluids of the de Sitter Horizon and Beyond
There are (at least) two surfaces of particular interest in eternal de Sitter
space. One is the timelike hypersurface constituting the lab wall of a static
patch observer and the other is the future boundary of global de Sitter space.
We study both linear and non-linear deformations of four-dimensional de Sitter
space which obey the Einstein equation. Our deformations leave the induced
conformal metric and trace of the extrinsic curvature unchanged for a fixed
hypersurface. This hypersurface is either timelike within the static patch or
spacelike in the future diamond. We require the deformations to be regular at
the future horizon of the static patch observer. For linearized perturbations
in the future diamond, this corresponds to imposing incoming flux solely from
the future horizon of a single static patch observer. When the slices are
arbitrarily close to the cosmological horizon, the finite deformations are
characterized by solutions to the incompressible Navier-Stokes equation for
both spacelike and timelike hypersurfaces. We then study, at the level of
linearized gravity, the change in the discrete dispersion relation as we push
the timelike hypersurface toward the worldline of the static patch. Finally, we
study the spectrum of linearized solutions as the spacelike slices are pushed
to future infinity and relate our calculations to analogous ones in the context
of massless topological black holes in AdS.Comment: 27 pages, 8 figure
Vacuum Ambiguity in de Sitter Space at Strong Coupling
It is well known that in the weak coupling regime, quantum field theories in
de Sitter space do not have a unique vacuum, but a class of vacua parametrized
by a complex parameter , i.e., the so-called -vacua. In this
article, using gauge/gravity duality, we calculate the symmetric two-point
function of strongly coupled supersymmetric Yang-Mills theory on
. We find that there is a class of de Sitter invariant vacua,
parametrized by a set of complex parameters .Comment: 17 pages in JHEP style, references adde
- …