13 research outputs found
History of adversity, health and psychopathology among prisoners: comparison between men and women
Adversity in childhood, risk behaviors
and psychopathology are highly prevalent phenomena
in inmate populations and have a strong
impact on health. Knowing the differences in these
variables between the sexes is most important in
order to develop appropriate intervention strategies
in a prison context. By administering the
Socio-demographic and Life History Questionnaire
and the Brief Symptoms Inventory, we
sought to characterize adverse childhood experiences
and relate them to risk behaviors and to
psychopathological symptoms, and study the differences
between the 65 male and 42 female detainees
in Portuguese prison establishments. Men
and women report a complex web of adversity in
childhood. In a range of ten possible categories, a
medium value of 5.05 (DP = 2.63) in total adversity
for women and 2.63 (DP = 2.18) for men was
encountered, with the prevalence being significantly
higher within the female population (Z =
-4.33; p = .000). A high prevalence of risk behaviors
and psychopathological symptoms was found
in both groups, the latter being higher among females.
We concluded that the differences between
men and women calls for in depth studies in order
to provide guidelines for intervention projects
in specific populations.Adversidade na infância, comportamentos
de risco e psicopatologia são fenómenos muito
prevalentes na população reclusa e com forte impacto
na saúde. Conhecer as diferenças entre sexos,
no que diz respeito a tais variáveis, é de elevada
importância no sentido de adequar estraté-
gias de intervenção em contexto prisional. Utilizando
o Questionário Sociodemográfico e Histó-
ria de Vida, o Questionário de Adversidade na
Infância e o Brief Symptons Inventory, procuramos
caracterizar a adversidade na infância, os
comportamentos de risco e as dimensões psicopatológicas,
e averiguar as diferenças entre 65 homens
e 42 mulheres reclusos em estabelecimentos
prisionais Portugueses. Homens e mulheres relatam
um quadro complexo de adversidade na infância.
Num total possível de dez categorias, verificamos
uma média de adversidade total de 5.05
(DP = 2.63) para as mulheres e de 2.63 (DP =
2.18) para os homens, sendo a prevalência significativamente
mais elevada junto da população
feminina (Z = -4.33; p = .000). Foi ainda encontrada
uma elevada prevalência de comportamentos
de risco e de sintomatologia psicopatológica
em ambos os grupos, sendo esta última superior
nas mulheres. Concluímos que as diferenças entre
sexos devem ser estudadas para guiarem a adequação
dos projetos
Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors.
Presentation of intracellular tumor-associated Ags (TAAs) in the context of HLA class I molecules offers unique cancer-specific cell surface markers for the identification and targeting of tumor cells. For most peptide Ags, the levels of and variations in cell surface presentation remain unknown, yet these parameters are of crucial importance when considering specific TAAs as targets for anticancer therapy. Here we use a soluble TCR with picomolar affinity for the HLA-A2-restricted 157-165 epitope of the NY-ESO-1 and LAGE-1 TAAs to investigate presentation of this immunodominant epitope on the surface of a variety of cancer cells. By single molecule fluorescence microscopy, we directly visualize HLA-peptide presentation for the first time, demonstrating that NY-ESO-1/LAGE-1-positive tumor cells present 10-50 NY-ESO-1/LAGE-1(157-165) epitopes per cell
Wittgenstein, Frazier and religion An analysis of the Remarks on Frazier's Golden Bough, illustrating the significance of Wittgenstein's view of magical and religious phenomena
SIGLEAvailable from British Library Document Supply Centre-DSC:DX205367 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
HIV/AIDS and Tourism in the Caribbean: An Ecological Systems Perspective
The Caribbean has the highest HIV rates outside of sub-Saharan Africa. In recent decades, tourism has become the most important Caribbean industry. Studies suggest that tourism areas are epicenters of demographic and social changes linked to HIV risk, such as transactional sex, elevated alcohol and substance use, and internal migration. Despite this, no formative HIV-prevention studies have examined tourism areas as ecologies that heighten HIV vulnerability. HIV/AIDS research needs to place emphasis on the ecological context of sexual vulnerability in tourism areas and develop multilevel interventions that are sensitive to this context. From our review and integration of a broad literature across the social and health sciences, we argue for an ecological approach to sexual health in Caribbean tourism areas, point to gaps in knowledge, and provide direction for future research