307 research outputs found
Impact-parameter dependent nuclear parton distribution functions: EPS09s and EKS98s and their applications in nuclear hard processes
We determine the spatial (impact parameter) dependence of nuclear parton
distribution functions (nPDFs) using the -dependence of the spatially
independent (averaged) global fits EPS09 and EKS98. We work under the
assumption that the spatial dependence can be formulated as a power series of
the nuclear thickness functions . To reproduce the -dependence over the
entire range we need terms up to . As an outcome, we release two
sets, EPS09s (LO, NLO, error sets) and EKS98s, of spatially dependent nPDFs for
public use. We also discuss the implementation of these into the existing
calculations. With our results, the centrality dependence of nuclear
hard-process observables can be studied consistently with the globally fitted
nPDFs for the first time. As an application, we first calculate the LO nuclear
modification factor for primary partonic-jet production in
different centrality classes in Au+Au collisions at RHIC and Pb+Pb collisions
at LHC. Also the corresponding central-to-peripheral ratios are
studied. We also calculate the LO and NLO nuclear modification factors for
single inclusive neutral pion production, , at mid- and
forward rapidities in different centrality classes in d+Au collisions at RHIC.
In particular, we show that our results are compatible with the PHENIX
mid-rapidity data within the overall normalization uncertainties given by the
experiment. Finally, we show our predictions for the corresponding
modifications in the forthcoming p+Pb collisions at LHC.Comment: 36 page
JIMWLK evolution in the Gaussian approximation
We demonstrate that the Balitsky-JIMWLK equations describing the high-energy
evolution of the n-point functions of the Wilson lines (the QCD scattering
amplitudes in the eikonal approximation) admit a controlled mean field
approximation of the Gaussian type, for any value of the number of colors Nc.
This approximation is strictly correct in the weak scattering regime at
relatively large transverse momenta, where it reproduces the BFKL dynamics, and
in the strong scattering regime deeply at saturation, where it properly
describes the evolution of the scattering amplitudes towards the respective
black disk limits. The approximation scheme is fully specified by giving the
2-point function (the S-matrix for a color dipole), which in turn can be
related to the solution to the Balitsky-Kovchegov equation, including at finite
Nc. Any higher n-point function with n greater than or equal to 4 can be
computed in terms of the dipole S-matrix by solving a closed system of
evolution equations (a simplified version of the respective Balitsky-JIMWLK
equations) which are local in the transverse coordinates. For simple
configurations of the projectile in the transverse plane, our new results for
the 4-point and the 6-point functions coincide with the high-energy
extrapolations of the respective results in the McLerran-Venugopalan model. One
cornerstone of our construction is a symmetry property of the JIMWLK evolution,
that we notice here for the first time: the fact that, with increasing energy,
a hadron is expanding its longitudinal support symmetrically around the
light-cone. This corresponds to invariance under time reversal for the
scattering amplitudes.Comment: v2: 45 pages, 4 figures, various corrections, section 4.4 updated, to
appear in JHE
Non-perturbative computation of double inclusive gluon production in the Glasma
The near-side ridge observed in A+A collisions at RHIC has been described as
arising from the radial flow of Glasma flux tubes formed at very early times in
the collisions. We investigate the viability of this scenario by performing a
non-perturbative numerical computation of double inclusive gluon production in
the Glasma. Our results support the conjecture that the range of transverse
color screening of correlations determining the size of the flux tubes is a
semi-hard scale, albeit with non-trivial structure. We discuss our results in
the context of ridge correlations in the RHIC heavy ion experiments.Comment: 25 pages, 11 figures, uses JHEP3.cls V2: small clarifications,
published in JHE
Potential of Resveratrol Analogues as Antagonists of Osteoclasts and Promoters of Osteoblasts
The plant phytoalexin resveratrol was previously demonstrated to inhibit the differentiation and bone resorbing activity of osteoclasts, to promote the formation of osteoblasts from mesenchymal precursors in cultures, and inhibit myeloma cell proliferation, when used at high concentrations. In the current study, we screened five structurally modified resveratrol analogues for their ability to modify the differentiation of osteoclasts and osteoblasts and proliferation of myeloma cells. Compared to resveratrol, analogues showed an up to 5,000-fold increased potency to inhibit osteoclast differentiation. To a lesser extent, resveratrol analogues also promoted osteoblast maturation. However, they did not antagonize the proliferation of myeloma cells. The potency of the best-performing candidate in vitro was tested in vivo in an ovariectomy-induced model of osteoporosis, but an effect on bone loss could not be detected. Based on their powerful antiresorptive activity in vitro, resveratrol analogues might be attractive modulators of bone remodeling. However, further studies are required to establish their efficacy in vivo
Effective Rheology of Bubbles Moving in a Capillary Tube
We calculate the average volumetric flux versus pressure drop of bubbles
moving in a single capillary tube with varying diameter, finding a square-root
relation from mapping the flow equations onto that of a driven overdamped
pendulum. The calculation is based on a derivation of the equation of motion of
a bubble train from considering the capillary forces and the entropy production
associated with the viscous flow. We also calculate the configurational
probability of the positions of the bubbles.Comment: 4 pages, 1 figur
Eag and HERG potassium channels as novel therapeutic targets in cancer
Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
uncorrected proofStress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal function. Here, we analyzed the role of Tau on stress-driven suppression of neurogenesis in the adult dentate gyrus (DG) using animals lacking Tau (Tau-knockout; Tau-KO) and wild-type (WT) littermates. Unlike WTs, Tau-KO animals exposed to chronic stress did not exhibit reduction in DG proliferating cells, neuroblasts and newborn neurons; however, newborn astrocytes were similarly decreased in both Tau-KO and WT mice. In addition, chronic stress reduced phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR)/glycogen synthase kinase-3 beta (GSK3 beta)/beta-catenin signaling, known to regulate cell survival and proliferation, in the DG of WT, but not Tau-KO, animals. These data establish Tau as a critical regulator of the cellular cascades underlying stress deficits on hippocampal neurogenesis in the adult brain.Portuguese Foundation for Science and Technology (FCT) Investigator grants (IF/01799/2013, IF/00883/2013, IF/01079/2014, respectively). This work was funded by FCT research grants 'PTDC/SAU-NMC/113934/2009' (IS), the Portuguese North Regional Operational Program (ON.2) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER), the Project Estratégico co-funded by FCT (PEst-C/SAU/LA0026/2013) and the European Regional Development Fund COMPETE (FCOMP-01-0124-FEDER-037298) as well as the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER)info:eu-repo/semantics/publishedVersio
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