Establishing the content validity in Hong Kong of the prioritised criteria of consultation competence in the Leicester Assessment Package (LAP)

Objective: To test the content validity in Hong Kong of the prioritised criteria of consultation competence in the Leicester Assessment Package (LAP). Design: A detailed questionnaire was sent to doctors with experience of family medicine in Hong Kong to seek their views on the seven prioritised consultation categories and 39 component competences in the LAP on a six-point scale (strongly approve to strongly disapprove). Respondents also had the opportunity to reject or suggest alternative categories, components and/or weightings. Background demographic and professional data were collected. Subjects: 489 full members of the HKCFP with current Hong Kong postal address. Main outcome measure: The respondents' collated levels of approval of the LAP consultation categories, component competences and weightings and any consensus for changes. Results: There was a response rate of 57%. Of the respondents 92%, and 82% to 97% either strongly approved or approved of the overall LAP set of consultation categories and the individual categories respectively. Thirty-seven of the 39 suggested component competences were supported by more than 80% of respondents. There was little support for excluding, including or shifting any categories or component competences. Ninety-three percent of respondents were in favour of the need to identify priorities between any categories of consultation competence and 88% of respondents expressed approval of the suggested weightings. Conclusion: The high levels of approval from respondents suggest that the content validity of the categories and components of consultation competence in the LAP has been established in Hong Kong and that the LAP weightings of consultation categories have also been validated. Indeed, the results closely correlate with the findings of the original study in the United Kingdom. The LAP criteria of consultation competence may be used with confidence as measures against which consultation performance can be judged in formative or regulatory assessment (and improvement) of consultation competence in family medicine in Hong Kong.published_or_final_versio

Nucleophilic substitution by amide nitrogen in the aromatic rings of [zn − H]˙+ ions; the structures of the [b2 − H − 17]˙+ and [c1 − 17]+ ions

Peptide radical cations that contain an aromatic amino acid residue cleave to give [zn − H]˙+ ions with [b2 − H − 17]˙+ and [c1 − 17]+ ions, the dominant products in the dissociation of [zn − H]˙+, also present in lower abundance in the CID spectra. Isotopic labeling in the aromatic ring of [Yπ˙GG]+ establishes that in the formation of [b2 − H − 17]˙+ ions a hydrogen from the δ-position of the Y residue is lost, indicating that nucleophilic substitution on the aromatic ring has occurred. A preliminary DFT investigation of nine plausible structures for the [c1 − 17]+ ion derived from [Yπ˙GG]+ shows that two structures resulting from attack on the aromatic ring by oxygen and nitrogen atoms from the peptide backbone have significantly better energies than other isomers. A detailed study of [Yπ˙GG]+ using two density functionals, B3LYP and M06-2X, with a 6-31++G(d,p) basis set gives a higher barrier for attack on the aromatic ring of the [zn − H]˙+ ion by nitrogen than by the carbonyl oxygen. However, subsequent rearrangements involving proton transfers are much higher in energy for the oxygen-substituted isomer leading to the conclusion that the [c1 − 17]+ ions are the products of nucleophilic attack by nitrogen, protonated 2,7-dihydroxyquinoline ions. The [b2 − H − 17]˙+ ions are formed by loss of glycine from the same intermediates involved in the formation of the [c1 − 17]+ ions.postprin

Measurement of cosmic-ray muons and muon-induced neutrons in the Aberdeen Tunnel Underground Laboratory

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An apparatus for studying spallation neutrons in the Aberdeen Tunnel laboratory

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Structure of hadron resonances with a nearby zero of the amplitude

We discuss the relation between the analytic structure of the scattering amplitude and the origin of an eigenstate represented by a pole of the amplitude.If the eigenstate is not dynamically generated by the interaction in the channel of interest, the residue of the pole vanishes in the zero coupling limit. Based on the topological nature of the phase of the scattering amplitude, we show that the pole must encounter with the Castillejo-Dalitz-Dyson (CDD) zero in this limit. It is concluded that the dynamical component of the eigenstate is small if a CDD zero exists near the eigenstate pole. We show that the line shape of the resonance is distorted from the Breit-Wigner form as an observable consequence of the nearby CDD zero. Finally, studying the positions of poles and CDD zeros of the KbarN-piSigma amplitude, we discuss the origin of the eigenstates in the Lambda(1405) region.Comment: 7 pages, 3 figures, v2: published versio

Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay

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Independent measure of the neutrino mixing angle θ13 via neutron capture on hydrogen at Daya Bay

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Measurement of electron antineutrino oscillation based on 1230 days of operation of the Daya Bay experiment

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Improved Search for a Light Sterile Neutrino with the Full Configuration of the Daya Bay Experiment

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The muon system of the Daya Bay Reactor antineutrino experiment

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