79 research outputs found
SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways
Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might otherwise threaten cell growth and development. Salt-inducible kinase 1 (SIK1) and salt overly sensitive 2 (SOS2) are key protein kinases within such networks in mammalian and plant cells, respectively. In animals, SIK1 expression and activity are regulated in response to the salt content of the diet, and in plants SOS2 activity is controlled by the salinity of the soil. The specific ionic stress (elevated intracellular sodium) is followed by changes in intracellular calcium; the calcium signals are sensed by calcium-binding proteins and lead to activation of SIK1 or SOS2. These kinases target major plasma membrane transporters such as the Na+,K+-ATPase in mammalian cells, and Na+/H+ exchangers in the plasma membrane and membranes of intracellular vacuoles of plant cells. Activation of these networks prevents abnormal increases in intracellular sodium concentration
Augmented Reality: What Motivates Late Millennials towards Fashion Mobile Apps?
Generation Z is expected to be a dominant demographic and economic group. Cyber-waviness,
constant reliance on smart devices that allows them to be always connected are among some of
their intrinsic characteristics. The combination of this reality with the ever-changing
technological environment is compelling retailers to reshape their business strategies, to meet
this group desires and expectations and to foster their engagement. Augmented reality (AR) is
emerging as a technological solution that pleases both consumers and retailers. This paper aims
to answer two main questions: (1) How does generation Z evaluate an AR experience? (2)
Which attributes/benefits do they value or not during an AR experience? Drawing on a
qualitative methodology â content analysis of 34 interviewees â we discuss six main
dimensions the potential customer value of the relationship between them and AR experiences
under retailer context.info:eu-repo/semantics/publishedVersio
Efflux in Fungi: La PiĂšce de RĂ©sistance
Pathogens must be able to overcome both host defenses and antimicrobial treatment in order to successfully infect and maintain colonization of the host. One way fungi accomplish this feat and overcome intercellular toxin accumulation is efflux pumps, in particular ATP-binding cassette transporters and transporters of the major facilitator superfamily. Members of these two superfamilies remove many toxic compounds by coupling transport with ATP hydrolysis or a proton gradient, respectively. Fungal genomes encode a plethora of members of these families of transporters compared to other organisms. In this review we discuss the role these two fungal superfamilies of transporters play in virulence and resistance to antifungal agents. These efflux transporters are responsible not only for export of compounds involved in pathogenesis such as secondary metabolites, but also export of host-derived antimicrobial compounds. In addition, we examine the current knowledge of these transporters in resistance of pathogens to clinically relevant antifungal agents
A new posttranslational regulation of REDD1/DDIT4 through cleavage by caspase 3 modifies its cellular function
Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects
Effective Heat Treatment for Improvement in Diamond-like Carbon Coatings for Biomedical Applications
Anti arthritic activity of aqueous extract of Indian black tea in experimental and clinical study
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