Indian health conditions.

This volume is a compendium of scholarly analyses of the health conditions that together constitute most of the illness borne by American Indians and Alaska Natives. Topics include; health intervention; cancer; cardiovascular diseases; diabetes; digestive system diseases; infant mortality; infectious diseases; maternal health; mental health and mental illness; musculosketetal system disease; oral disease; end-stage renal disease; respiratory diseases; violence; substance abuse; and accidental injuries. This publication was developed in 1986 and although, the data are several years old, much of the analyses and recommendations are still relevant today. It also serves as an important historical or reference document for the Indian Health Service. Each analysis provides an overview of a particular health condition as it affects the IHS service population nationwide and suggests, recommendations regarding the steps that IHS can take to reduce and eventually eliminate the described health problems

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most bronchiectasis is reported to be idiopathic however post-infectious aetiologies dominate across Asia especially secondary to tuberculosis. Most focus to date has been on the study of airway bacteria, both as colonisers and causes of exacerbations. Modern molecular technologies including next generation sequencing (NGS) have become invaluable tools to identify microorganisms directly from sputum and which are difficult to culture using traditional agar based methods. These have provided important insight into our understanding of emerging pathogens in the airways of people with bronchiectasis and the geographical differences that occur. The contribution of the lung microbiome, its ethnic variation, and subsequent roles in disease progression and response to therapy across geographic regions warrant further investigation. This review summarises the known geographical differences in the aetiology, epidemiology and microbiology of bronchiectasis. Further, we highlight the opportunities offered by emerging molecular technologies such as -omics to further dissect out important ethnic differences in the prognosis and management of bronchiectasis.NMRC (Natl Medical Research Council, S’pore)MOH (Min. of Health, S’pore)Published versio

The quality of research synthesis in surgery: the case of laparoscopic surgery for colorectal cancer

Peer reviewedPublisher PD

Indian health conditions.

This volume is a compendium of scholarly analyses of the health conditions that together constitute most of the illness borne by American Indians and Alaska Natives. Topics include; health intervention; cancer; cardiovascular diseases; diabetes; digestive system diseases; infant mortality; infectious diseases; maternal health; mental health and mental illness; musculosketetal system disease; oral disease; end-stage renal disease; respiratory diseases; violence; substance abuse; and accidental injuries. This publication was developed in 1986 and although, the data are several years old, much of the analyses and recommendations are still relevant today. It also serves as an important historical or reference document for the Indian Health Service. Each analysis provides an overview of a particular health condition as it affects the IHS service population nationwide and suggests, recommendations regarding the steps that IHS can take to reduce and eventually eliminate the described health problems