8 research outputs found
Study of Metal-Metal Interactions and Their Biomarkers Using an Intestinal Human Cell Line
No full textEnhanced Refrigerant Capacity and Magnetic Entropy Nearly Flattening in (La 2 / 3 Ba 1 / 3 MnO 3 ) 1 â x / (La 2 / 3 Ba 1 / 3 MnO 2 . 9 8 ) x Composite
No full textInvestigation of Iron Metabolism in Mice Expressing a Mutant Menkeâs Copper Transporting ATPase (Atp7a) Protein with Diminished Activity (Brindled; MoBr/y)
No full textHigh-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats
No full text
Copper uptake and trafficking in the brain
No full textThe aim of this chapter is to give a general view on the current status of the scientific basis for the role of copper in human health and disease, outlining the roles of copper in human metabolism and bioenergetics, its coordination chemistry as well as the biological ligands involved in the multiple steps of metal incorporation. In particular, our attention has been focused towards the interaction of copper status and brain function in health and disease, with particular consideration to the role of copper in the pathogenesis of Wilsonâs, of Menkesâs, and of human neurodegenerative diseases. Data on interactions between essential trace elements and copper, from the level of absorption in the gut to other systems in the body, are also presented. Particular attention is paid to copper-dependent enzymes in the central nervous system and to copper uptake and trafficking in brain cells
