Eradication of unresectable liver metastasis through induction of tumour specific energy depletion.

Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable of eliminating metastatic cancer cells in a selective manner. Nucleus-targeting W18O49 nanoparticles (WONPs) are conjugated to mitochondria-selective mesoporous silica nanoparticles (MSNs) containing photosensitizer (Ce6) through a Cathepsin B-cleavable peptide. In hepatocytes, upon the laser irradiation, the generated singlet oxygen species are consumed by WONPs, in turn leading to the loss of their photothermally heating capacity, thereby sparing hepatocyte from thermal damage induced by the laser illumination. By contrast, in cancer cells, the cleaved peptide linker allows WONPs and MSNs to respectively target nucleus and mitochondria, where the therapeutic powers could be unleashed, both photodynamically and photothermally. This ensures the energy production of cancer cells can be abolished. We further assess the underlying molecular mechanism at both gene and protein levels to better understand the therapeutic outcome

Test of quantum nonlocality via vector meson decays to KSKSK_SK_S

In the system of a pair of quantum-entangled neutral kaons from meson decays, when one kaon collapses into the $K_S$ state, the other will collapse instantaneously into the $K_L$ state due to entanglement and nonlocality. However, if the alternative hypothesis is correct and there's a time window during which one kaon is unaware that the other has decayed, some quantum mechanically prohibited $K_SK_S$ decays may occur. We calculate the branching ratios of $K_SK_S$ in vector meson decays under the locality hypothesis and compare them with experimental results. We show that the branching ratio of $J/\psi\rightarrow K_SK_S$ under locality assumption is already excluded by the BESIII experimental upper limit. Additional experimental results are proposed to perform this test in the future.Comment: 7 pages, 3 figures, 1 tabl

{μ-2-[4-(Benzothia­zol-2-yl)benz­yl]-2-aza­propane-1,3-dithiol­ato-1:2κ4 S,S′:S,S′}bis­[tricarbonyl­iron(I)]

The title compound, [Fe2(C16H14N2S3)(CO)6], was prepared as the biomimetic model for the active site of iron-only hydrogenase. The structure is similar to the diiron subsite of the iron-only hydrogenase active site, and contains a diiron-aza­dithiol­ate moiety in which a boat six-membered ring is fused with a chair six-membered ring. The substituted benzyl group attached to the bridging N atom resides in an equatorial position. The sum of the C—N—C angles around this N atom [331.9 (12)°] indicates sp 3 hybridization

Hall anomaly by vacancies vs fragments of vortex lattice: Quantitative analyses of new evidences

Despite numerous recent studies on the Hall anomaly following the discovery of cuprate superconductivity, the origin of this phenomenon remains contentious. We demonstrate that a previously proposed mechanism, in which vacancy-on-fragment of the flux-line crystal, provides an alternative explanation for the observations of $\rm{Bi_{2}Sr_{2}CaCu_{2}O_{x}}$ thin films made by Nitzav and Kanigel [Phys. Rev. B. 107, 094516 (2023)], without the need for adjustable parameters. Specifically, we show that the power-law behavior of $\rho_{xy}$ over $\rho_{xx}$, with and without sign reversal, is consistent with the picture of vacancies versus fragments. Interestingly, we find that the effective length of vortex lines is consistently 1.5 unit cells (UC) across different experiments, independent of film thickness.Comment: arXiv admin note: substantial text overlap with arXiv:2206.0338

Separating sexual dimorphism from other morphological variation in a specimen complex of fossil marine reptiles (Reptilia, Ichthyosauriformes, Chaohusaurus).

The Early Triassic Chaohu Fauna from Anhui Province, China, contains the oldest record of Mesozoic marine reptiles, such as Cartorhynchus and Sclerocormus. Most specimens from the fauna belong to the ichthyosauriform Chaohusaurus, more specifically resembling C. chaoxianensis. However, a wide range of morphological variation exists within about 40 skeletons that have been prepared, likely reflecting mixed signals from both sexual and taxonomic differences. We test whether the sexual and taxonomic signals are separable based on quantification, aided by the knowledge of sexual dimorphism in extant marine tetrapods. There are two different suites of dimorphism that divide the specimens differently from each other yet consistently within each suite, resulting in four morphotypes in combination, likely representing two sexes of two taxa. Presumed males have larger organ of prehension sensu Darwin, specifically limbs in the present case, for a given body length. This sexing criterion is supported by the only specimen of a gravid female, which belongs to the morphotype with short limbs. Males also have larger skulls for the trunk length compared to females. This study demonstrates that sexual and taxonomic signals are separable in fossil reptiles, with a sufficient sample size and careful analyses

Poly[[[silver(I)-μ-1,4-bis­[(imidazol-1-yl)meth­yl]benzene-κ2 N 3:N 3′-silver(I)-μ-1,4-bis­[(imidazol-1-yl)meth­yl]benzene-κ2 N 3:N 3′] 4,4′-diazenediyldibenzoate] dihydrate]

In the title compound, [Ag2(C14H14N4)2](C14H8N2O4)·2H2O, each of the two unique Ag+ ions is two-coordinated by two N atoms from two different 1,4-bis­[(imidazol-1-yl)meth­yl]benzene ligands in an almost linear fashion [N—Ag—N = 170.34 (10) and 160.25 (10)°]. The 4,4′-diazenediyldibenzoate anions do not coordinate to Ag. O—H⋯O hydrogen bonds stabilize the crystal structure