Intraocular Pressure Fluctuation: Is It Important?

Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of glaucoma. Previous prospective, randomized, long-term studies have demonstrated the strength of IOP reduction in slowing the progression of disease. It is well known that IOP is not a fixed value but fluctuates considerably over time. Although there have been some studies on IOP fluctuation and the progression of glaucoma, whether IOP fluctuation is an independent risk factor for glaucomatous damage and disease progression remains controversial. In this article, we reviewed the definition of IOP fluctuation, and both the evidence and the speculation for and against the effect of IOP fluctuation on glaucoma progression. Although conclusions seem to vary from study to study, we considered that different studies examined different groups of patients, at different stages of disease, and at different IOP levels. Our conclusion is that these apparently disparate results are not conflicting, but rather can be viewed as complementary. In clinical care, we recommend the consideration of IOP "modulation" rather than just IOP "reduction" when glaucoma patients are treated. Quality-based IOP control may be more effective than quantity-based IOP reduction to prevent or retard disease progression

A systems-biology approach to understanding the ciliopathy disorders.

'Ciliopathies' are an emerging class of genetic multisystemic human disorders that are caused by a multitude of largely unrelated genes that affect ciliary structure/function. They are unified by shared clinical features, such as mental retardation, cystic kidney, retinal defects and polydactyly, and by the common localization of the protein products of these genes at or near the primary cilium of cells. With the realization that many previously disparate conditions are a part of this spectrum of disorders, there has been tremendous interest in the function of cilia in developmental signaling and homeostasis. Ciliopathies are mostly inherited as simple recessive traits, but phenotypic expressivity is under the control of numerous genetic modifiers, putting these conditions at the interface of simple and complex genetics. In this review, we discuss the ever-expanding ciliopathy field, which has three interrelated goals: developing a comprehensive understanding of genes mutated in the ciliopathies and required for ciliogenesis; understanding how the encoded proteins work together in complexes and networks to modulate activity and structure-function relationships; and uncovering signaling pathways and modifier relationships

The second-phase development of the China JinPing underground Laboratory

During 2013-2015 an expansion of the China JinPing underground Laboratory (CJPL) will be undertaken along a main branch of a bypass tunnel in the JinPing tunnel complex. This second phase of CJPL will increase laboratory space to approximately 96,000 m^3, which can be compared to the existing CJPL-I volume of 4,000 m^3. One design configuration has eight additional hall spaces, each over 60 m long and approximately 12 m in width, with overburdens of about 2.4 km of rock, oriented parallel to and away from the main water transport and auto traffic tunnels. Concurrent with the excavation activities, planning is underway for dark matter and other rare-event detectors, as well as for geophysics/engineering and other coupled multi-disciplinary sensors. In the town meeting on 8 September, 2013 at Asilomar, CA, associated with the 13th International Conference on Topics in Astroparticle and Underground Physics (TAUP), presentations and panel discussions addressed plans for one-ton expansions of the current CJPL germanium detector array of the China Darkmatter EXperiment (CDEX) collaboration and of the duel-phase xenon detector of the Panda-X collaboration, as well as possible new detector initiatives for dark matter studies, low-energy solar neutrino detection, neutrinoless double beta searches, and geoneutrinos. JinPing was also discussed as a site for a low-energy nuclear astrophysics accelerator. Geophysics/engineering opportunities include acoustic and micro-seismic monitoring of rock bursts during and after excavation, coupled-process in situ measurements, local, regional, and global monitoring of seismically induced radon emission, and electromagnetic signals.Comment: 9 pages, 3 figures. 13th International Conference on Topics in Astroparticle and Underground Physics, TAUP 201

ECONOMIC IMPACTS OF BANNING SUBTHERAPEUTIC USE OF ANTIBIOTICS IN SWINE PRODUCTION

Public health officials and physicians are concerned about possible development of bacterial resistance and potential effects on human health that may be related to the use of antimicrobial agents in livestock feed. The focus of this research is aimed at determining the economic effects that subtherapeutic bans of antimicrobials would have on both swine producers and consumers. The results show that a ban on growth promotants for swine would be costly, totaling $242.5 million annually, with swine producers sharing the larger portion in the short run and consumers sharing the larger portion in the long run.banning subtherapeutic use, feed efficiency, mortality rate, sort loss, Livestock Production/Industries, Q18, D61,

ECONOMIC IMPACTS OF BANNING SUBTHERAPEUTIC USE OF ANTIBIOTICS IN SWINE PRODUCTION

Public health officials and physicians are concerned about possible development of bacterial resistance and potential effects on human health that may be related to the use of antimicrobial agents in livestock feed. The focus of this research is aimed at determining the economic effects that subtherapeutic bans of antimicrobials would have on both swine producers and consumers. The results show that a ban on growth promotants for swine would be costly, totaling $242.5 million annually with swine producers sharing the larger portion in the short run and consumers sharing about 75$586 million per year with swine producers sharing about the same as in bans for swine only and consumers sharing significantly more than the swine only case.Crop Production/Industries,

Electron Parallel Closures for the 3 + 1 Fluid Model

Linear closures are obtained for arbitrary collisionality for the 3 þ 1 fluid model which includes the evolution of density, flow velocity, and pressure both parallel and perpendicular to a preferred direction, usually a magnetic field. A large set of 6400 moment equations is solved to provide closures that are accurate in the collisional regime and well into the collisionless regime. The closures in the collisionless limit are determined by solving the kinetic equation with a model collision operator. Simple fits for the kernel functions that define the closures are obtained for arbitrary collisionality in wave number space. The results are linearly accurate to within 3% across the entire range of collisionality