10 research outputs found
Predictive comparison of joint longitudinal-survival modeling: a case study illustrating competing approaches
- Author
- AA Tsiatis
- Adam J. Branscum
- AJ Branscum
- CL Faucett
- DR Cox
- DR Cox
- EJ Bedrick
- ER Brown
- ER Brown
- F Hsieh
- H-G MĂĽller
- H-G MĂĽller
- JA Rice
- JG Ibrahim
- JM Chiou
- JO Berger
- JR Carey
- JR Carey
- L Fahrmeir
- M Lavine
- M Lavine
- M Zhang
- M-H Chen
- M-H Chen
- MS Wulfsohn
- NJ Law
- NM Laird
- OO Aalen
- P Blasi De
- P Bycott
- R Schoop
- R Yang
- RD Mauldin
- RL Prentice
- RL Prentice
- S Banerjee
- S Geisser
- S Lang
- S Sundaram
- SM Paddock
- T Hanson
- T Hanson
- T Martinussen
- TE Hanson
- TE Hanson
- Timothy E. Hanson
- TM Therneau
- TS Ferguson
- Wesley O. Johnson
- X Song
- X Song
- Y Wang
- Y-K Tseng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture
- Author
- A Svedbom
- AC Phillips
- Andreas Kurth
- B Abrahamsen
- B Gullberg
- B Peter
- B Sobolev
- BA Christiansen
- BL Langdahl
- C Cooper
- C Cryer
- C Raas
- C Woo
- CA Inderjeeth
- CL Leibson
- CM Girgis
- Congress US
- D Marsh
- DL Kopperdahl
- DM Black
- DM Black
- DM Black
- E Basafa
- E Basafa
- E Basafa
- E Chiarello
- E Gaumetou
- E Hernlund
- E Lonnroos
- EF Eriksen
- EG Sutter
- ES LeBlanc
- F Borgstrom
- F Johannesdottir
- G Holzer
- GA Kelley
- HG Bone
- HK Kamel
- HR Springorum
- I Ekrol
- I Wolff
- J Beckmann
- J Magaziner
- J Ryg
- J Schilcher
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Kanis
- JA Sterling
- JC Banwart
- JD Holmes
- JD Ringe
- JE Compston
- JE Koivumaki
- Jean-Marc FĂ©ron
- Jean-Marc Kaufman
- Jean-Pierre Devogelaer
- Jean-Yves Reginster
- JG Seiler 3rd
- John A. Kanis
- JY Reginster
- K Akesson
- K Engelke
- K Imai
- K Stoffel
- KE Poole
- KW Lyles
- L Blum
- L Cianferotti
- L Zani
- LE Lanyon
- LJ Melton 3rd
- M Cree
- M Laursen
- M Scaglione
- M Szpalski
- Maria Luisa Brandi
- MK Javaid
- MR McClung
- N Dobelin
- O Johnell
- P Haentjens
- P Kothawala
- P Piscitelli
- PF Heini
- PJ Ehrlich
- PM Mayhew
- R Burge
- R Dimitriou
- R Madhok
- R Rizzoli
- R Rudang
- RB Silva
- RD Chapurlat
- René Rizzoli
- RM Neer
- RM Zebaze
- RW McCalden
- S Boonen
- S Boutroy
- S Giannini
- S Iuliano-Burns
- S Nawathe
- S Papapoulos
- S Silverman
- S Zimmerman
- SC Faucett
- SC Kim
- SD Berry
- SE Papapoulos
- Serge Ferrari
- SH Kim
- SK Eswaran
- SL Bass
- SR Cummings
- ST Harris
- T Alarcon
- T Whitmarsh
- TM Keaveny
- TM Keaveny
- U Kettenberger
- V Elliot-Gibson
- VA Stadelmann
- VA Stadelmann
- W Kemmler
- W Pistoia
- WR Moore
- YK Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Missing data methods in longitudinal studies: a review
- Author
- A Ekholm
- A Rotnitzky
- AA Tsiatis
- AB Troxel
- AB Troxel
- AH Herring
- AH Herring
- AH Herring
- AH Herring
- AL Stubbendick
- AL Stubbendick
- AP Dempster
- C Beunckens
- CL Faucett
- D Follman
- D Renard
- D Rizopoulos
- DB Rubin
- DB Rubin
- DO Scharfstein
- E Lesaffre
- ER Brown
- ER Brown
- ER Brown
- G Molenberghs
- G Molenberghs
- G Molenberghs
- G Verbeke
- GC Wei
- Geert Molenberghs
- GM Fitzmaurice
- GM Fitzmaurice
- GM Fitzmaurice
- GM Fitzmaurice
- GM Fitzmaurice
- H Thijs
- H-T Zhu
- I Meilijson
- J Carpenter
- J Xu
- JG Ibrahim
- JG Ibrahim
- JG Ibrahim
- JG Ibrahim
- JG Ibrahim
- JG Ibrahim
- JG Ibrahim
- JG Ibrahim
- JG Ibrahim
- JM Robins
- JMG Taylor
- Joseph G. Ibrahim
- JW Hogan
- JW Hogan
- K-Y Liang
- L Huang
- M-H Chen
- M-H Chen
- M-H Chen
- M-H Chen
- M-H Chen
- MC Wu
- MC Wu
- MC Wu
- MD Schluchter
- MJ Daniels
- MK Cowles
- MP Lavalley
- NE Breslow
- NG Best
- NM Laird
- P Diggle
- PJ Diggle
- Q Chen
- Q Chen
- Q Chen
- R Henderson
- R Wolfinger
- RD Cook
- RF Woolson
- RI Jennrich
- RJ Beckman
- RJA Little
- RJA Little
- RJA Little
- RJA Little
- RJA Little
- RL Prentice
- RWM Wedderburn
- SL Zeger
- SR Lipsitz
- SR Lipsitz
- SR Lipsitz
- SR Lipsitz
- SR Lipsitz
- T Louis
- V DeGruttola
- WR Gilks
- Y Chi
- Y Chi
- Y Pawitan
- Publication venue
- Publication date
- Field of study
Expectation-maximization algorithm, Incomplete data, Missing completely at random, Missing at random, Missing not at random, Pattern-mixture model, Selection model, Sensitivity analyses, Shared-parameter model, 62J05, 62J12, 62P10,
Linking Regional Economic Models for Policy Analysis
- Author
- BH Stevens
- Bureau of Economic Analysis (BEA)
- Bureau of the Census
- C Almon Jr
- CH Sawyer
- DH Garnick
- DH Garnick
- EAC (Economic Adjustment Committee)
- EAC (Economic Adjustment Committee)
- F Giarrantani
- F Giarratani
- FG Adams
- G Treyz
- G Treyz
- HO Nourse
- HW Richardson
- JG Faucett
- JI Round
- JI Round
- JI Round
- JR Kort
- JR Kort
- JV Cartwright
- JV Cartwright
- JV Cartwright
- JV Cartwright
- JV Cartwright
- JW Kendrick
- K Ballard
- KR Polenske
- NJ Glickman
- P Bourque
- R Bodkin
- R Bolton
- RD Gustely
- RE Miller
- RL Drake
- RM Seguy
- RS Conway
- RS Preston
- RS Preston
- W Isard
- W L’Esperance
- WA Schaffer
- WA Schaffer
- WI Morrison
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1986
- Field of study
Cost effectiveness of the type II Boston keratoprosthesis
- Author
- A Solomon
- AI Mushlin
- AJ Aldave
- BG Busbee
- BG Busbee
- C H Dohlman
- C Hirneiss
- C Liu
- C McCabe
- CH Dohlman
- CH Dohlman
- CH Dohlman
- CS Foster
- E Losina
- F Xie
- F Yaghouti
- G Falcinelli
- G Geerling
- G Geerling
- G N Papaliodis
- GC Brown
- I Tugal-Tutkun
- J Chodosh
- J D Ament
- JD Ament
- JD Dayton
- JG Dohlman
- JJ Jacobson
- JS Cummins
- MM Brown
- MM Brown
- MR Gold
- N Devlin
- N Kontodimopoulos
- RR Sayegh
- RW Chang
- S Pujari
- S Sharma
- S Siddique
- SC Faucett
- SC Griffin
- SD Pinkerton
- T P Stryjewski
- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Dynamic predictions in Bayesian functional joint models for longitudinal and time-to-event data: An application to Alzheimer’s disease
- Author
- Apostolova LG
- Apostolova LG
- Blanche P
- Cardot H
- Cleveland WS
- Corder E
- Cui Y
- Diggle P
- Du AT
- Faucett CL
- Gertheiss J
- Gilks WR
- Goldsmith J
- Goldsmith J
- Greven S
- Heagerty PJ
- Hoffman MD
- James GM
- James GM
- Kan Li
- Lee E
- Li K
- Li S
- Lo RY
- Morris JS
- MĂĽller HG
- Ormerod JT
- Peng J
- Qiu A
- Ramsay JO
- Reiss PT
- Risacher SL
- Rizopoulos D
- Rizopoulos D
- Ruppert D
- Sheng Luo
- Staniswalis JG
- Stefan Lang AB
- Taylor JM
- Wang JL
- Weiner MW
- Wulfsohn MS
- Yang L
- Yao F
- Zhang D
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Joint modeling of multivariate longitudinal data and the dropout process in a competing risk setting: application to ICU data
- Author
- A Tsiatis
- A Tsiatis
- B Saville
- CL Faucett
- D Schoenfeld
- D Spiegelhalter
- E Deslandes
- Emmanuelle Deslandes
- F Ambrogi
- F Bilotta
- F Hsieh
- G Touloumi
- H Jacqmin-Gadda
- H Lin
- H Putter
- HD Spapen
- J Fine
- J Robins
- J Satagopan
- J Vincent
- JG Ibrahim
- JP Fine
- JW Hogan
- L Li
- L Liu
- LA McIntyre
- M Hernan
- M Lunn
- M Resche-Rigon
- M Wolkewitz
- M Wu
- MC Wu
- MJZL Liu
- MS Wulfsohn
- N Li
- N Li
- P Diggle
- P Royston
- PR Williamson
- R Ceriani
- R Davis
- R Development Core Team
- R Gray
- R Henderson
- R Thiebaut
- RM Elashoff
- RM Elashoff
- S Rosthoj
- Sylvie Chevret
- TL Higgins
- W Hu
- W Knaus
- W Ye
- X Guo
- X Song
- Y Liang
- YY Chi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Joint modelling of time-to-event and multivariate longitudinal outcomes: recent developments and issues
- Author
- AA Tsiatis
- AA Tsiatis
- AL Gould
- Andrea Jorgensen
- AP Dempster
- C Proust-Lima
- C Proust-Lima
- C Wang
- CL Faucett
- D Lunn
- D Rizopoulos
- D Rizopoulos
- D Rizopoulos
- D Rizopoulos
- D Zhang
- DO Scharfstein
- DR Cox
- E Dantan
- E-R Andrinopoulou
- E-R Andrinopoulou
- ER Brown
- ER Brown
- F Bartolucci
- F Hsieh
- F Liu
- G Touloumi
- G Verbeke
- Graeme L. Hickey
- H Lin
- H Putter
- H Zhu
- HC Doran
- I Sousa
- J Choi
- J Guedj
- J Xu
- J-F Dupuy
- JG Ibrahim
- JG Ibrahim
- JW Hogan
- JW Hogan
- JZ Musoro
- LA Hatfield
- LC Battes
- LM Chen
- LM McCrink
- MA Jaffa
- MD Escobar
- MJ Crowther
- MJ Sweeting
- MS Wulfsohn
- N Li
- N Pantazis
- N Pantazis
- NM Laird
- NS Tang
- P Ghisletta
- P Royston
- P Wang
- Pete Philipson
- PJ Diggle
- PS Albert
- R Henderson
- R Thiébaut
- R Tsonaka
- Ruwanthi Kolamunnage-Dona
- S Fieuws
- S Fieuws
- S Luo
- S Luo
- S Self
- T Baghfalaki
- T Baghfalaki
- W Huang
- X Guo
- X Song
- X Song
- YY Chi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Joint modeling of longitudinal health-related quality of life data and survival
- Author
- A Bottomley
- A Cull
- AA Tsiatis
- AA Tsiatis
- Andrew Bottomley
- Bernard M. J. Uitdehaag
- C Boor de
- C Quinten
- CC Gotay
- CL Faucett
- Corneel Coens
- D Osoba
- D Osoba
- D Rizopoulos
- D Rizopoulos
- D Zeng
- DE Ediebah
- Divine E. Ediebah
- DT Eton
- E Deslandes
- Efstathios Zikos
- F Hsieh
- Francisca Galindo-Garre
- G Schwarz
- G Touloumi
- H Jacqmin-Gadda
- Jaap C. Reijneveld
- JG Ibrahim
- JH Abbring
- JL Horowitz
- Jolie Ringash
- JW Hogan
- L Li
- L Liu
- Linda Dirven
- LM Chen
- M Wu
- Martin J. B. Taphoorn
- Martin J. van den Bent
- MJ Bent van den
- MJ Sweeting
- MJB Taphoorn
- NK Aaronson
- PJ Diggle
- R Henderson
- R Thiebaut
- RJA Little
- RJA Little
- RM Elashoff
- SAS Institute Inc
- V DeGruttola
- W Ye
- X Song
- Y Liang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
- Aranda M
- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
- Arias V
- Armada E
- Armstrong P
- Arnold A
- Arnold M
- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
- Aylward P
- Ayres T
- Azize G
- Azrin M
- Azzolini P
- Babu R
- Bach R
- Badings EA
- Baeza N
- Baig M
- Baiz A
- Bajcsi É
- Balaguera J
- Balcells E
- Baldari D
- Baldus S
- Bali H
- Ballantyne C
- Ballmer P
- Banerjee S
- Bang-Hansen T
- Banikova A
- Bankowski D
- Banks K
- Bansal M
- Baraona F
- Barber C
- Barber C
- Barbir M
- Barillas O
- Barnes D
- Barnett O
- Barr C
- Barrett J
- Barringhaus K
- Barron M
- Bartels GL
- Basilio E
- Bass M
- Bassand J
- Bassand JP
- Bassand JP
- Basso V
- Bata I
- Battikadi S
- Battin D
- Bauer B
- Baumanns S
- Bautista J
- Bayat J
- Bayer M
- Bayer M
- Bayles A
- Bazzi A
- Beaudry M
- Bedoya R
- Been M
- Belicova M
- Bell K
- Belle L
- Beloscar J
- Beltran R
- Beltrano MC
- Ben-Aharon J
- Ben-Yehuda O
- Benetar J
- Bengtsson PO
- Bennermo M
- Bennett J
- Benyahya L
- Beresford P
- Berezniakov I
- Berger M
- Berger-Kucza A
- Bergeron J
- Berglund M
- Berglund R
- Bergsten J
- Berk M
- Berli M
- Bernardi D
- Berra F
- Berrospi P
- Bertolet B
- Bescos L
- Bethea C
- Bethencourt A
- Betti I
- Betzu R
- Bhalla H
- Bhalodkar N
- Bhargava M
- Bhargava R
- Bhargavi M
- Bhesania T
- Biasucci L
- Biedermann B
- Bikkina M
- Bilazarian S
- Bilodeau N
- Bin Ismail O
- Binaghi G
- Birkemeyer R
- Birnbaum Y
- Bishop A
- Bishop B
- Bishop C
- Bissett J
- Bissett J
- Bittel B
- Bitzer V
- Bjornstad H
- Blacher MG
- Blais D
- Blank E
- Blazing M
- Blazing M
- Blazing M
- Blazing Michael A.
- Blessing E
- Block D
- Bluguermann J
- Blumberg E
- Bobek M
- Bocconcelli P
- Bocconcelli P
- Bodanese L
- Bodenstein W
- Boehm S
- Bogomolny N
- Bohle D
- Bohlscheid V
- Bohorquez R
- Bohula Erin A.
- Boliek W
- Bolli R
- Bolsman C
- Bonatti S
- Bondi L
- Bondio M
- Bone C
- Bonnet J
- Bono J
- Book K
- Boomer L
- Boos C
- Botero R
- Bottzauw J
- Botwin S
- Boudriot E
- Bouvier JM
- Bowden W
- Bozek B
- Bradford L
- Bradford L
- Brady A
- Brady A
- Brady A
- Braga J
- Branca G
- Branny M
- Branzi A
- Braun P
- Braunwald Eugene
- Breen J
- Brike C
- Britto F
- Britto F
- Britto F
- Broadwater S
- Bronnum-Schou J
- Brossoit R
- Brown C
- Brown C
- Brown C
- Brown J
- Brunelli C
- Brunelli C
- Brunk S
- Bruno N
- Brunvand H
- Brussee H
- Bryniarski L
- Budzon S
- Bueno M
- Buerke M
- Buerke M
- Bugos V
- Buijs EM
- Buijs F
- Bullivant M
- Burgess L
- Burghard S
- Burley T
- Burton J
- Buss I
- Bustamante G
- Butcher R
- Butkus E
- Butter C
- Buzetti C
- Byfuglien A
- Cabrera-Santamaria A
- CalderĂłn MJ
- Calic S
- Califf
- Calpar I
- Calzolari D
- Campbell C
- Campbell T
- Campos C
- Cannon C
- Cannon C
- Cannon Christopher P.
- Canto J
- Cappelen H
- Capucci A
- Capucci A
- Cardillo MT
- Cardinal F
- Cardoso A
- Carell E
- Carell E
- Carey C
- Carlessi C
- Carlevaro O
- Carling-Chambers L
- Carlsson F
- Carmelo M
- Carr K
- Carrageta M
- Carrageta M
- Carrageta M
- Carrié D
- Carswell BS
- Cartasegna L
- Caruso O
- Casalins M
- Casares G
- Caso P
- Caspi A
- Cassadonte F
- Cassavar D
- Cassel G
- Castoldi M
- Castro P
- Castro R
- Catarino C
- Caussin C
- Cauthren T
- Cavallini C
- Ceder-Brolin K
- Centeno E
- Centurion C
- Cepeda M
- Cequier A
- Chadwyn D
- Chae SC
- Chalavarya G
- Chambers J
- Chandler G
- Chandna H
- Chandna H
- Chandna H
- Chandra P
- Chandraratna P
- Chandrasekaran S
- Chang D
- Chang G
- Chang K
- Chang K
- Chang M
- Charng M
- Chattree K
- Chavarri M
- Chavez V
- Chee K
- Chernick R
- Chessa P
- Cheung S
- Chew D
- Chhabra A
- Chian-Yi W
- Chiariello M
- Chilakamarri V
- Childs A
- Childs C
- Chiodi L
- Chiu A
- Cho M
- Choi Y
- Cholewa M
- Chopra A
- Chopra V
- Christopher J
- Christy L
- Chronos N
- Chu A
- Chui K
- Chung W
- Ciampricotti R
- Cianflone D
- Cicia G
- Cihalik C
- Ciliberti D
- Cirillo W
- Ciuti G
- Cizinsky S
- Clarke A
- Clarus S
- Clausen H
- Clausen H
- Clavero X
- Clemmensen P
- Cleveland D
- Cleveland T
- Cloud B
- Cobos M
- Cocco N
- Coelho O
- Coetzee C
- Coffin N
- Coffman A
- Cohen B
- Cohen LE
- Cohen Y
- Coisne D
- Coldwell J
- Colfer H
- Collins J
- Collins J
- Collins T
- Colombo H
- Commerford P
- Conaway D
- Connolly T
- Constance C
- Conti M
- Cooke J
- Cooke L
- Corbalan R
- Corbalan R
- Corbett C
- Cortada J
- Corut S
- Cossett J
- Costa M
- Costantini C
- Costello T
- Cottin Y
- Coviaux F
- Coy K
- Craig M
- Crandall L
- Crawford K
- Cristaldi J
- Cristell N
- Cronje T
- Cross D
- Crutchfield B
- Cryderman C
- CsapĂł K
- Cubeddu L
- Cuccia C
- Cullen T
- Curry R
- Curtis S
- Cush S
- Cusimano S
- Cyncar R
- D'Urso M
- da Costa FA
- da Cunha C
- Dagefoerde N
- Dahiya R
- Dalby A
- Dalby A
- Dalby A
- Dale H
- Daley P
- Dalin L
- Dambrine P
- Damiano M
- Damiano S
- Damm T
- Dani S
- Daniel D
- Daniels MC
- Danse IY
- Darcel I
- Darius H
- Darius H
- Darius H
- Darius Harald
- Darnell Z
- Dauber I
- Dave R
- David M
- Davidovits S
- Davidson L
- Davis B
- Davis C
- Davis G
- Davis T
- Davis W
- Davy J
- Dawson G
- De Andrade M
- De Belder M
- de Carvalho Moreira R
- De Caterina R
- De Clippel M
- De Feo S
- De Ferrari G
- De Ferrari G
- De Ferrari Gaetano M.
- De Ferrari GM
- De Gregorio M
- de la Guia F
- de la Guia F
- De Larochelliere R
- de Lemos J
- De Lemos J
- De Lucca Paul
- De Maria E
- de Sa E
- de Salazar D
- de Souza J
- de Teresa E
- de Valdecilla H
- De Velder L
- De Wolf L
- Debrouwer K
- Decker S
- DeFranco A
- Del Core M
- del Rio A
- Dela Cruz C
- Delahaye F
- Delgado J
- Delio-Cox B
- Della Siega A
- Dellatorre M
- Dellborg M
- Dellborg M
- Dellborg M
- Delport E
- Demarcq JM
- Dempsey K
- Den Hartog FR
- DeRaad R
- Desai V
- Desalca M
- DeSimone L
- DeVault S
- Devlin G
- Dhooghe G
- Di Biase M
- Di Fazio J
- Di Pasquale G
- Diadema B
- Dias D
- Dickinson D
- Dietz S
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- Ă…ngman K
- Édes I
- Ă–stberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit