A Svedbom

AC Phillips

Andreas Kurth

B Abrahamsen

B Gullberg

B Peter

B Sobolev

BA Christiansen

BL Langdahl

C Cooper

C Cryer

C Raas

C Woo

CA Inderjeeth

CL Leibson

CM Girgis

Congress US

D Marsh

DL Kopperdahl

DM Black

E Basafa

E Chiarello

E Gaumetou

E Hernlund

E Lonnroos

EF Eriksen

EG Sutter

ES LeBlanc

F Borgstrom

F Johannesdottir

G Holzer

GA Kelley

HG Bone

HK Kamel

HR Springorum

I Ekrol

I Wolff

J Beckmann

J Magaziner

J Ryg

J Schilcher

JA Kanis

JA Sterling

JC Banwart

JD Holmes

JD Ringe

JE Compston

JE Koivumaki

Jean-Marc Féron

Jean-Marc Kaufman

Jean-Pierre Devogelaer

Jean-Yves Reginster

JG Seiler 3rd

John A. Kanis

JY Reginster

K Akesson

K Engelke

K Imai

K Stoffel

KE Poole

KW Lyles

L Blum

L Cianferotti

L Zani

LE Lanyon

LJ Melton 3rd

M Cree

M Laursen

M Scaglione

M Szpalski

Maria Luisa Brandi

MK Javaid

MR McClung

N Dobelin

O Johnell

P Haentjens

P Kothawala

P Piscitelli

PF Heini

PJ Ehrlich

PM Mayhew

R Burge

R Dimitriou

R Madhok

R Rizzoli

R Rudang

RB Silva

RD Chapurlat

René Rizzoli

RM Neer

RM Zebaze

RW McCalden

Abstract
          
            
              Summary
            
            This review provides a critical analysis of currently available approaches to increase bone mass, structure and strength through drug therapy and of possible direct intra-osseous interventions for the management of patients at imminent risk of hip fracture.
          
          
            Purpose
            Osteoporotic hip fractures represent a particularly high burden in morbidity-, mortality- and health care-related costs. There are challenges and unmet needs in the early prevention of hip fractures, opening the perspective of new developments for the management of osteoporotic patients at imminent and/or at very high risk of hip fracture. Amongst them, preventive surgical intervention needs to be considered.
          
          
            Methods
            A European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)/International Osteoporosis Foundation (IOF) working group reviewed the presently available intervention modalities including preventive surgical options for hip fragility. This paper represents a summary of the discussions.
          
          
            Results
            Prevention of hip fracture is currently based on regular physical activity; prevention of falls; correction of nutritional deficiencies, including vitamin D repletion; and pharmacological intervention. However, efficacy of these various measures to reduce hip fractures is at most 50% and may need months or years before becoming effective. To face the challenges of early prevention of hip fractures for osteoporotic patients at imminent and/or at very high risk of hip fracture, preventive surgical intervention needs further investigation.
          
          
            Conclusion
            Preventive surgical intervention needs to be appraised for osteoporotic patients at imminent and/or at very high risk of hip fracture.
          </jats:sec

Serge Ferrari

Crossref

Archives of Osteoporosis

Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture

https://link.springer.com/content/pdf/10.1007%2Fs11657-016-0292-1.pdf

Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture

Abstract

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