Public libraries and non-users: A comparison between Manchester and Rome

This paper presents the findings of a study conducted with library managers from two major metropolitan areas, Greater Manchester in England and Rome in Italy. The study aims to compare practices, activities and policies adopted in the two cities to attract non-users, with particular attention to the approach that librarians take to resolving the non-user issue. This research also revealed differences in the way public libraries are used in the two areas. In Manchester, libraries are predominantly task orientated, offering access points for community services, whereas in Rome the focus is more on entertainment, leisure, and social events. The non-user profiles differ between cities, with non-users being mostly older teenagers and young adults in Manchester and mostly younger teenagers and pensioners in Rome. Reading groups, a key service for encouraging reading and familiarising with library facilities, are well established in England, with 90% of the libraries in Manchester accommodating one or more groups, compared to only 50% of the libraries in Rome offering usually a single group. In addition, Manchester libraries often have a range of specialised reading groups to suit a large variety of reading tastes. Libraries in both cities are aware of the need for proactive marketing and management of their web presence but should look at other countries’ strategies to expand their range of activities and programmes to attract more public

Administration of interferon-<FONT FACE=Symbol>g</font> to pregnant rats reverses the depressed adjuvant-induced arthritis of their chronically Trypanosoma cruzi-infected offspring

We demonstrated that administration of interferon gamma (IFN-<FONT FACE="Symbol">g</font>) to the inbred "l" strain of pregnant rats conferred partial resistance on their offspring to challenge with Trypanosoma cruzi. We now examine if this intervention also modifies the reportedly immunodepressed cellular responses which occur during chronic infection. Offspring were born to mothers undergoing one of the following procedures during gestation: subcutaneous injections of recombinant rat IFN-<FONT FACE="Symbol">g</font>, 50,000 IU/rat, five times/week for 3 weeks, which was started on the day of mating (IFN-Mo); infection with 106 trypomastigotes of T. cruzi at 7, 14, and 21 days after mating plus IFN-<FONT FACE="Symbol">g</font> treatment as given to the former group (TcIFN-Mo); the same protocol except that physiological saline was injected instead of IFN-<FONT FACE="Symbol">g</font> (Tc-Mo); injection of physiological saline only (control-Mo). All offspring groups (N = 8-10/group) were infected at weaning and were assessed 90 days later for their adjuvant-induced arthritic response or levels of major T cell subsets in spleen and lymph nodes. TcIFN-Mo and IFN-Mo offspring showed a reestablished arthritic response, which remained within the range seen in controls. Immunolabeling studies on parallel groups of 90-day-infected offspring showed that the inverse CD4/CD8 cell ratio that is usually seen in lymphoid organs from these chronically infected rats (median 0.61) appeared to have recovered in the TcIFN-Mo and IFN-Mo groups (median 1.66 and 1.78, respectively) and was not different from uninfected controls (1.96). These studies indicate that early stimulation with IFN-<FONT FACE="Symbol">g</font> is able to reverse the immunosuppressive state that is usually present during the chronic period of the experimental infection