2,141 research outputs found
Hall viscosity from gauge/gravity duality
In (2+1)-dimensional systems with broken parity, there exists yet another
transport coefficient, appearing at the same order as the shear viscosity in
the hydrodynamic derivative expansion. In condensed matter physics, it is
referred to as "Hall viscosity". We consider a simple holographic realization
of a (2+1)-dimensional isotropic fluid with broken spatial parity. Using
techniques of fluid/gravity correspondence, we uncover that the holographic
fluid possesses a nonzero Hall viscosity, whose value only depends on the
near-horizon region of the background. We also write down a Kubo's formula for
the Hall viscosity. We confirm our results by directly computing the Hall
viscosity using the formula.Comment: 12 page
The role of Cra in regulating acetate excretion and osmotic tolerance in E. coli K-12 and E. coli B at high density growth
<p>Abstract</p> <p>Background</p> <p><it>E. coli </it>B (BL21), unlike <it>E.coli </it>K-12 (JM109) is insensitive to glucose concentration and, therefore, grows faster and produces less acetate than <it>E. coli </it>K-12, especially when growing to high cell densities at high glucose concentration. By performing genomic analysis, it was demonstrated that the cause of this difference in sensitivity to the glucose concentration is the result of the differences in the central carbon metabolism activity. We hypothesized that the global transcription regulator Cra (FruR) is constitutively expressed in <it>E. coli </it>B and may be responsible for the different behaviour of the two strains. To investigate this possibility and better understand the function of Cra in the two strains, <it>cra </it>- negative <it>E. coli </it>B (BL21) and <it>E. coli </it>K-12 (JM109) were prepared and their growth behaviour and gene expression at high glucose were evaluated using microarray and real-time PCR.</p> <p>Results</p> <p>The deletion of the <it>cra </it>gene in <it>E. coli </it>B (BL21) minimally affected the growth and maximal acetate accumulation, while the deletion of the same gene in <it>E.coli </it>K-12 (JM109) caused the cells to stop growing as soon as acetate concentration reached 6.6 g/L and the media conductivity reached 21 mS/cm. <it>ppsA </it>(gluconeogenesis gene), <it>aceBA </it>(the glyoxylate shunt genes) and <it>poxB </it>(the acetate producing gene) were down-regulated in both strains, while <it>acs </it>(acetate uptake gene) was down-regulated only in <it>E.coli </it>B (BL21). These transcriptional differences had little effect on acetate and pyruvate production. Additionally, it was found that the lower growth of <it>E. coli </it>K-12 (JM109) strain was the result of transcription inhibition of the osmoprotectant producing <it>bet </it>operon (<it>betABT</it>).</p> <p>Conclusions</p> <p>The transcriptional changes caused by the deletion of <it>cra </it>gene did not affect the activity of the central carbon metabolism, suggesting that Cra does not act alone; rather it interacts with other pleiotropic regulators to create a network of metabolic effects. An unexpected outcome of this work is the finding that <it>cra </it>deletion caused transcription inhibition of the <it>bet </it>operon in <it>E. coli </it>K-12 (JM109) but did not affect this operon transcription in <it>E. coli </it>B (BL21). This property, together with the insensitivity to high glucose concentrations, makes this the <it>E. coli </it>B (BL21) strain more resistant to environmental changes.</p
Comparison and Mapping Facilitate Relation Discovery and Predication
Relational concepts play a central role in human perception and cognition, but little is known about how they are acquired. For example, how do we come to understand that physical force is a higher-order multiplicative relation between mass and acceleration, or that two circles are the same-shape in the same way that two squares are? A recent model of relational learning, DORA (Discovery of Relations by Analogy; Doumas, Hummel & Sandhofer, 2008), predicts that comparison and analogical mapping play a central role in the discovery and predication of novel higher-order relations. We report two experiments testing and confirming this prediction
Charge-spin correlation in van der Waals antiferromagenet NiPS3
Strong charge-spin coupling is found in a layered transition-metal
trichalcogenide NiPS3, a van derWaals antiferromagnet, from our study of the
electronic structure using several experimental and theoretical tools:
spectroscopic ellipsometry, x-ray absorption and photoemission spectroscopy,
and density-functional calculations. NiPS3 displays an anomalous shift in the
optical spectral weight at the magnetic ordering temperature, reflecting a
strong coupling between the electronic and magnetic structures. X-ray
absorption, photoemission and optical spectra support a self-doped ground state
in NiPS3. Our work demonstrates that layered transition-metal trichalcogenide
magnets are a useful candidate for the study of correlated-electron physics in
two-dimensional magnetic material.Comment: 6 pages, 3 figur
HAE-RAE Bench: Evaluation of Korean Knowledge in Language Models
Large Language Models (LLMs) trained on massive corpora demonstrate
impressive capabilities in a wide range of tasks. While there are ongoing
efforts to adapt these models to languages beyond English, the attention given
to their evaluation methodologies remains limited. Current multilingual
benchmarks often rely on back translations or re-implementations of English
tests, limiting their capacity to capture unique cultural and linguistic
nuances. To bridge this gap for the Korean language, we introduce HAE-RAE
Bench, a dataset curated to challenge models lacking Korean cultural and
contextual depth. The dataset encompasses six downstream tasks across four
domains: vocabulary, history, general knowledge, and reading comprehension.
Contrary to traditional evaluation suites focused on token or sequence
classification and specific mathematical or logical reasoning, HAE-RAE Bench
emphasizes a model's aptitude for recalling Korean-specific knowledge and
cultural contexts. Comparative analysis with prior Korean benchmarks indicates
that the HAE-RAE Bench presents a greater challenge to non-native models, by
disturbing abilities and knowledge learned from English being transferred.Comment: Revised Erro
Comprehensive three-dimensional analysis of right-sided aortic arch with multiple vascular anomalies
Rapid suppression of quantum many-body magnetic exciton in doped van der Waals antiferromagnet (Ni,Cd)PS3
The unique discovery of magnetic exciton in van der Waals antiferromagnet
NiPS3 arises between two quantum many-body states of a Zhang-Rice singlet
excited state and a Zhang-Rice triplet ground state. Simultaneously, the
spectral width of photoluminescence originating from this exciton is
exceedingly narrow as 0.4 meV. These extraordinary properties, including the
extreme coherence of the magnetic exciton in NiPS3, beg many questions. We
studied doping effects using Ni1-xCdxPS3 using two experimental techniques and
theoretical studies. Our experimental results show that the magnetic exciton is
drastically suppressed upon a few % Cd doping. All these happen while the width
of the exciton only gradually increases, and the antiferromagnetic ground state
is robust. These results highlight the lattice uniformity's hidden importance
as a prerequisite for coherent magnetic exciton. Finally, an exciting scenario
emerges: the broken charge transfer forbids the otherwise uniform formation of
the coherent magnetic exciton in (Ni,Cd)PS3.Comment: 40 pages, 4 main figures, 13 supporting figures, accepted by Nano
Letter
Unconventional spin-phonon coupling via the Dzyaloshinskii???Moriya interaction
Spin-phonon coupling (SPC) plays a critical role in numerous intriguing phenomena of transition metal oxides (TMOs). In 3d and 4d TMOs, the coupling between spin and lattice degrees of freedom is known to originate from the exchange interaction. On the other hand, the origin of SPC in 5d TMOs remains to be elucidated. To address this issue, we measured the phonon spectra of the 5d pyrochlore iridate Y 2 Ir 2 O 7 using optical spectroscopy. Three infrared-active phonons soften below the N??el temperature of T N ??? 170 K, indicating the existence of strong SPC. Simulations using density functional theory showed that the coupling is closely related to the Ir???O???Ir bond angle. A tight-binding model analysis reveals that this SPC is mainly mediated by the Dzyaloshinskii???Moriya interaction rather than the usual exchange interaction. We suggest that such unconventional SPC may be realized in other 5d TMOs with non-collinear magnetic order
Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation
Paclitaxel is a chemotherapeutic drug commonly used to treat different types of cancer. In addition to its antitumor effect, paclitaxel is also known to promote Toll-like receptor (TLR) 4-dependent inflammatory responses, which may lower its chemotherapeutic efficacy. However, it remains unclear whether paclitaxel is able to affect inflammasome signaling in myeloid or cancer cells. Therefore, we examined the potential effect of paclitaxel on the activation of an inflammasome complex by examining caspase-1 activation and interleukin (IL)-1β secretion in bone marrow-derived macrophages (BMDMs). The results showed that treatment with paclitaxel alone or following LPS priming failed to trigger the secretion of active caspase-1 and IL-1β from BMDMs. However, paclitaxel could induce robust activation of caspase-1 in BMDMs in the presence of NLRP3 inflammasome-activating signal 2, such as ATP or nigericin. This paclitaxel/ATP-mediated inflammasome activation was completely abrogated in Nlrp3-deficient macrophages. Mechanistically, paclitaxel treatment induced robust activation of the TLR4 signaling cascade, including phosphorylation of IκB and JNK and upregulation of proinflammatory cytokine mRNA levels in a TLR4-dependent manner. In contrast, paclitaxel treatment alone did not induce mitochondrial damages such as the loss of the mitochondrial membrane potential and production of mitochondrial ROS. These findings suggest that paclitaxel can drive the priming of signal-mediated events for NLRP3 activation but not a second signal-triggered phenomenon such as mitochondrial damage. This suggestion was supported by the observations that paclitaxel treatment caused robust IL-1β production in macrophages in the presence of cell-free medium derived from growth of injured cells and also in the spleen of mice. Collectively, our data strongly indicate that paclitaxel is able to facilitate the activation of NLRP3 inflammasome signaling in a certain physiological environment
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