Phase-resolved Hubble Space Telescope ultraviolet spectroscopy

We present highly time-resolved HST FOS UV spectroscopy of the nova-like binary V795 Her. Several key results emerge. For the first time we find a strong 2.6-h signature in the variability of the UV lines. The HST data reveal no evidence of a 4.8-h ‘period’, in contrast to our previous IUE observations. This, and differences in the spectral line characteristics, suggests that HST found the system in a different state from earlier IUE observations. The C IV line alone contains a fairly stable, asymmetric, extended blueward absorption trough which we associate with a wind outflow. The 2.6-h variations of the line profiles are largely confined to an interval of about 0.4 in phase and to the velocity regime −1500 < v < 0 km s−1, the changes being dominated by the apparent decline and re-emergence of a blueshifted emission peak. The complex profiles permit many empirical interpretations, but the simplest attributes the variability to a narrow (FWHM∼1000 km s−1) emission component which is always blueshifted with a mean velocity of around –600 km s−1. This interpretation, however, is not readily related to any obvious source within the binary. An alternative picture, which attempts to relate the UV and (simultaneously observed) optical line behaviour, invokes a more stable, broad (FWHM∼2000 km s−1) emission feature, the intrinsic morphology of which is disguised by superposed constant and variable absorption components. One tentative physical explanation of such a decomposition involves an accretion stream that overflows the accretion disc. However, several problems with this model remain to be resolved. We also draw attention to similarities between the velocity-restricted behaviour in the UV lines of V795 Her and that in the optical lines of T Tauri stars. This might indicate a connection between V795 Her and the magnetically influenced inflow/outflow characteristics associated with the central star in T Tauri systems. If such a connection were eventually demonstrated, it would reopen the question of whether the 2.6-h period in V795 Her is really the binary period and whether the system is in fact related to the intermediate polars

The psychological functioning of children with Epidermolysis Bullosa (EB) and its relationship with specific aspects of disease

Epidermolysis Bullosa (EB) is a group of genetic conditions resulting in skin and mucosal membrane fragility. EB is characterised by chronic wounds and scarring, consequent functional limitations and high levels of pain. In its most severe forms, life expectancy is significantly foreshortened

Mapping a nation’s landslides: a novel multi-stage methodology

Through combining new technologies and traditional mapping techniques, the British Geological Survey (BGS) has developed a novel, multi-stage methodology for landslide mapping. 3-D aerial photograph interpretation, variable-perspective 3-D topographic visualisation and field mapping with digital data capture are being used to map the UK’s landslides. The resulting ESRI ArcGIS polygons are published on BGS 1:50,000 geological maps and as digital data products. Data collected during mapping are also uploaded directly into the National Landslides Database maintaining a systematic, nationally-uniform landslide inventory. Repeat monitoring of selected landslides using terrestrial LIDAR and dGPS allows the database to be frequently updated and the proactive Landslide Response Team means that new landslide events can be mapped within days, if not hours, of their occurrence. The long-term aim is to apply this methodology throughout the UK, providing a wealth of data for scientific research and hazard assessment. This methodology is also suitable for application in an international context

Friction factor and heat transfer correlation for irradiated organic coolants

"September 1965."Series statement handwritten on cover"MIT-334-23 Chemistry."Also written as an M.S. theses written by the first author and advised by the second author, Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1966Includes bibliographical references (pages 163-165)M.I.T. DSR Project no. 9819Work performed for the Savannah River Operations Office, U.S. Atomic Energy Commission under contract no. AT(38-1)-33

In-pile loop irradiation studies of organic coolant materials : progress report, October 1, 1963 - December 31, 1964,

Statement of responsibility on title page reads: Report prepared by: E. A. Mason, Project Supervisor; Contributors: W.N. Bley, J.C. Kim, T.H. Timmins, J.F. Terrien, A.H. Swan"Issued: February 1, 1965.""AEC Research and Development Report"--Cover"MIT-334-12."Includes bibliographical references (leaves 21-22)Progress report; October 1, 1963 - December 31, 1964M.I.T. Project no. DSR 9819U.S. Atomic Energy Commission, Savannah River Operations Office contract no. AT(38-1)-33

The Thermal Design, Characterization, and Performance of the SPIDER Long-Duration Balloon Cryostat

We describe the SPIDER flight cryostat, which is designed to cool six millimeter-wavelength telescopes during an Antarctic long-duration balloon flight. The cryostat, one of the largest to have flown on a stratospheric payload, uses liquid helium-4 to deliver cooling power to stages at 4.2 and 1.6 K. Stainless steel capillaries facilitate a high flow impedance connection between the main liquid helium tank and a smaller superfluid tank, allowing the latter to operate at 1.6 K as long as there is liquid in the 4.2 K main tank. Each telescope houses a closed cycle helium-3 adsorption refrigerator that further cools the focal planes down to 300 mK. Liquid helium vapor from the main tank is routed through heat exchangers that cool radiation shields, providing negative thermal feedback. The system performed successfully during a 17 day flight in the 2014-2015 Antarctic summer. The cryostat had a total hold time of 16.8 days, with 15.9 days occurring during flight.Comment: 15 pgs, 17 fig

Evaluating the Viscoelastic Properties of Tissue from Laser Speckle Fluctuations

Most pathological conditions such as atherosclerosis, cancer, neurodegenerative, and orthopedic disorders are accompanied with alterations in tissue viscoelasticity. Laser Speckle Rheology (LSR) is a novel optical technology that provides the invaluable potential for mechanical assessment of tissue in situ. In LSR, the specimen is illuminated with coherent light and the time constant of speckle fluctuations, τ, is measured using a high speed camera. Prior work indicates that τ is closely correlated with tissue microstructure and composition. Here, we investigate the relationship between LSR measurements of τ and sample mechanical properties defined by the viscoelastic modulus, G*. Phantoms and tissue samples over a broad range of viscoelastic properties are evaluated using LSR and conventional mechanical testing. Results demonstrate a strong correlation between τ and |G*| for both phantom (r = 0.79, p <0.0001) and tissue (r = 0.88, p<0.0001) specimens, establishing the unique capability of LSR in characterizing tissue viscoelasticity

Who will use pre-exposure prophylaxis (PrEP) and why?: Understanding PrEP awareness and acceptability amongst men who have sex with men in the UK – a mixed methods study

Background: Recent clinical trials suggest that pre-exposure prophylaxis (PrEP) may reduce HIV transmission by up to 86% for men who have sex with men (MSM), whilst relatively high levels of PrEP acceptability have been reported to date. This study examines PrEP awareness amongst sub-groups of MSM communities and acceptability amongst MSM in a low prevalence region (Scotland, UK), using a mixed methods design. Methods: Quantitative surveys of n = 690 MSM recruited online via social and sociosexual media were analysed using descriptive statistics and multivariate logistic regression. In addition, n = 10 in-depth qualitative interviews with MSM were analysed thematically. Results: Under one third (29.7%) of MSM had heard of PrEP, with awareness related to living in large cities, degree level education, commercial gay scene use and reporting an HIV test in the last year. Just under half of participants (47.8%) were likely to use PrEP if it were available but there was no relationship between PrEP acceptability and previous PrEP awareness. Younger men (18–25 years) and those who report higher risk UAI were significantly more likely to say they would use PrEP. Qualitative data described specific PrEP scenarios, illustrating how risk, patterns of sexual practice and social relationships could affect motivation for and nature of PrEP use. Conclusion: These findings suggest substantial interest PrEP amongst MSM reporting HIV risk behaviours in Scotland. Given the Proud results, there is a strong case to investigate PrEP implementation within the UK. However, it appears that disparities in awareness have already emerged along traditional indicators of inequality. Our research identifies the need for comprehensive support when PrEP is introduced, including a key online component, to ensure equity of awareness across diverse MSM communities (e.g. by geography, education, gay scene use and HIV proximity), as well as to responding to the diverse informational and sexual health needs of all MSM communities

Are lay people good at recognising the symptoms of schizophrenia?

©2013 Erritty, Wydell. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Aim: The aim of this study was to explore the general public’s perception of schizophrenia symptoms and the need to seekhelp for symptoms. The recognition (or ‘labelling’) of schizophrenia symptoms, help-seeking behaviours and public awareness of schizophrenia have been suggested as potentially important factors relating to untreated psychosis. Method: Participants were asked to rate to what extent they believe vignettes describing classic symptoms (positive and negative) of schizophrenia indicate mental illness. They were also asked if the individuals depicted in the vignettes required help or treatment and asked to suggest what kind of help or treatment. Results: Only three positive symptoms (i.e., Hallucinatory behaviour, Unusual thought content and Suspiciousness) of schizophrenia were reasonably well perceived (above 70%) as indicating mental illness more than the other positive or negative symptoms. Even when the participants recognised that the symptoms indicated mental illness, not everyone recommended professional help. Conclusion: There may be a need to improve public awareness of schizophrenia and psychosis symptoms, particularly regarding an awareness of the importance of early intervention for psychosis

Young women's use of a microbicide surrogate: The complex influence of relationship characteristics and perceived male partners' evaluations

This is the post-print version of the article. The official published version can be found at the link below.Currently in clinical trials, vaginal microbicides are proposed as a female-initiated method of sexually transmitted infection prevention. Much of microbicide acceptability research has been conducted outside of the United States and frequently without consideration of the social interaction between sex partners, ignoring the complex gender and power structures often inherent in young women’s (heterosexual) relationships. Accordingly, the purpose of this study was to build on existing microbicide research by exploring the role of male partners and relationship characteristics on young women’s use of a microbicide surrogate, an inert vaginal moisturizer (VM), in a large city in the United States. Individual semi-structured interviews were conducted with 40 young women (18–23 years old; 85% African American; 47.5% mothers) following use of the VM during coital events for a 4 week period. Overall, the results indicated that relationship dynamics and perceptions of male partners influenced VM evaluation. These two factors suggest that relationship context will need to be considered in the promotion of vaginal microbicides. The findings offer insights into how future acceptability and use of microbicides will be influenced by gendered power dynamics. The results also underscore the importance of incorporating men into microbicide promotion efforts while encouraging a dialogue that focuses attention on power inequities that can exist in heterosexual relationships. Detailed understanding of these issues is essential for successful microbicide acceptability, social marketing, education, and use.This study was funded by a grant from National Institutes of Health (NIHU19AI 31494) as well as research awards to the first author: Friends of the Kinsey Institute Research Grant Award, Indiana University’s School of HPER Graduate Student Grant-in-Aid of Research Award, William L. Yarber Sexual Health Fellowship, and the Indiana University Graduate and Professional Student Organization Research Grant