28 research outputs found
Prenatal diagnosis of Caudal Regression Syndrome : a case report
BACKGROUND: Caudal regression is a rare syndrome which has a spectrum of congenital malformations ranging from simple anal atresia to absence of sacral, lumbar and possibly lower thoracic vertebrae, to the most severe form which is known as sirenomelia. Maternal diabetes, genetic predisposition and vascular hypoperfusion have been suggested as possible causative factors. CASE PRESENTATION: We report a case of caudal regression syndrome diagnosed in utero at 22 weeks' of gestation. Prenatal ultrasound examination revealed a sudden interruption of the spine and "frog-like" position of lower limbs. Termination of pregnancy and autopsy findings confirmed the diagnosis. CONCLUSION: Prenatal ultrasonographic diagnosis of caudal regression syndrome is possible at 22 weeks' of gestation by ultrasound examination
Medida do comprimento do osso nasal entre 11 e 15 semanas de gestação em uma população brasileira: estudo preliminar
Increased nuchal translucency with normal karyotype
Increased fetal nuchal translucency (NT) thickness between 11 and 14
weeks’ gestation is a common phenotypic expression of chromosomal
abnormalities, including trisomy 21. However, even in the absence of
aneuploidy, nuchal thickening is clinically relevant because it is
associated with an increase in adverse perinatal Outcome caused by a
variety of fetal malformations, dysplasias, deformations, dysruptions,
and genetic syndromes. Once the presence of aneuploidy is ruled Out, the
risk of perinatal Outcome close not statistically increase until the
nuchal translucency measurement reaches 3.5 min or more (> 99th
percentile). This increase in risk Occurs in an exponential fashion as
the NT measurement increases. However, if the fetus survives until
midgestation, and if a targeted ultrasound at 20 to 22 weeks fails to
reveal any abnormalities, the risk of an adverse perinatal outcome and
postriatal developmental delay is not statistically increased. (c) 2005
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