9 research outputs found
Respiratory syncytial virus infection increases chlorine-induced airway hyperresponsiveness
P2Y6 receptors are involved in mediating the effect of inactivated avian influenza virus H5N1 on IL-6 & CXCL8 mRNA expression in respiratory epithelium
Spontaneous remission of “methotrexate-associated lymphoproliferative disorders” after discontinuation of immunosuppressive treatment for autoimmune disease. Review of the literature
Hemophagocytosis induced by Leishmania donovani infection is beneficial to parasite survival within macrophages
Stem cell therapy: a potential approach for treatment of influenza virus and coronavirus-induced acute lung injury
The emerging role of ADAM metalloproteinases in immunity
Proteolysis is an irreversible physiological process that can result in the termination or activation of protein function. Many transmembrane proteins that are involved in the cellular communication between immune cells and structural cells-for example, Notch, CD23, CD44, and membrane-anchored cytokines and their receptors-are cleaved by the ADAM (a disintegrin and metalloproteinase) family of enzymes. Here, we review recent insights into the molecular activation, substrate specificity and function of ADAM proteins in the development and regulation of the immune system, with a particular focus on the roles of ADAM10 and ADAM17