41 research outputs found
Responsiveness, minimal important difference, minimal relevant difference, and optimal number of patients for a study
Potential problems in the use of patient reported outcome measures (PROMs) and reporting of PROM data in sports science
Dispersal strategies, few dominating or many coexisting: the effect of environmental spatial structure and multiple sources of mortality.
Interspecific competition, life history traits, environmental heterogeneity and spatial structure as well as disturbance are known to impact the successful dispersal strategies in metacommunities. However, studies on the direction of impact of those factors on dispersal have yielded contradictory results and often considered only few competing dispersal strategies at the same time. We used a unifying modeling approach to contrast the combined effects of species traits (adult survival, specialization), environmental heterogeneity and structure (spatial autocorrelation, habitat availability) and disturbance on the selected, maintained and coexisting dispersal strategies in heterogeneous metacommunities. Using a negative exponential dispersal kernel, we allowed for variation of both species dispersal distance and dispersal rate. We showed that strong disturbance promotes species with high dispersal abilities, while low local adult survival and habitat availability select against them. Spatial autocorrelation favors species with higher dispersal ability when adult survival and disturbance rate are low, and selects against them in the opposite situation. Interestingly, several dispersal strategies coexist when disturbance and adult survival act in opposition, as for example when strong disturbance regime favors species with high dispersal abilities while low adult survival selects species with low dispersal. Our results unify apparently contradictory previous results and demonstrate that spatial structure, disturbance and adult survival determine the success and diversity of coexisting dispersal strategies in competing metacommunities
Development of a Valid and Reliable Knee Articular Cartilage Condition–Specific Study Methodological Quality Score
High temperature surface Brillouin scattering study of mechanical properties of boron-doped epitaxial polysilicon
A study of the mechanical properties of a boron-doped epitaxial polysilicon layer
deposited on a Si (100) substrate specimen has been carried out by surface Brillouin scattering at high
temperatures. This type of specimen is widely used in micro-electro-mechanical
systems (MEMS). By
accumulating spectra with the Rayleigh mode and the Lamb continuum the isotropic elastic
constants C44 and C11 were obtained, from which the values of the
bulk, shear and Young’s moduli and Poisson’s ratio for the layer were determined over a range
of temperatures from 20 °C to 110 °C. By contrast, an examination of the literature on
polycrystalline
silicon shows that
other methods each provide a limited range of the above properties and thus additional
experiments and techniques were needed. The SBS method is applicable to other polycrystalline materials such
as silicon
carbide, silicon
nitride, silicon
germanium and amorphous diamond that have also been used for MEMS applications
Determination of the elastic properties of a barrier film on aluminium by Brillouin spectroscopy
Development and validation of a condition-specific diary to measure severity, bothersomeness and impact on daily activities for patients with acute urinary tract infection in primary care
BACKGROUND: Urinary tract infection (UTI) is a common condition in primary care. Patient-reported outcome measures (PROMs) are crucial in the evaluation of interventions to improve diagnosis, treatment and prognosis of UTI. The aim of this study was to identify an existing condition-specific PROM to measure symptom severity, bothersomeness and impact on daily activities for adult patients with suspected urinary tract infection in primary care; or, in the absence of such a PROM, to test items identified from existing PROMs for coverage and relevance in single and group interviews and to psychometrically validate the resulting PROM. METHODS: The literature was searched for existing PROMs covering the three domains. Items from the identified PROMs were tested in single and group interviews. The resulting symptom diary was psychometrically validated using the partial credit Rasch model for polytomous items in a cohort of 451 women participating in two studies regarding UTI. RESULTS: No existing PROM fulfilled the inclusion criteria. Content validation resulted in one domain concerning symptom severity (18 items), one concerning bothersomeness (18 items), and one concerning impact on daily activities (7 items). Psychometrical validation resulted in four dimensions in each of the first two domains and one dimension in the third domain. CONCLUSIONS: Domains were not unidimensional, which meant that we identified dimensions of patient-experienced UTI that differed substantially from those previously found. We recommend that future studies on UTI, in which PROMs are to be used, should ensure high content validity of their outcome measures and unidimensionality of the included dimensions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12955-017-0629-5) contains supplementary material, which is available to authorized users
