8 research outputs found
Spontaneous Stratification in Granular Mixtures
Granular materials size segregate when exposed to external periodic
perturbations such as vibrations. Moreover, mixtures of grains of different
sizes spontaneously segregate in the absence of external perturbations: when a
mixture is simply poured onto a pile, the large grains are more likely to be
found near the base, while the small grains are more likely to be near the top.
Here, we report a spontaneous phenomenon arising when we pour a mixture between
two vertical plates: the mixture spontaneously stratifies into alternating
layers of small and large grains whenever the large grains are rougher than the
small grains. In contrast, we find only spontaneous segregation when the large
grains are more rounded than the small grains. The stratification is related to
the occurrence of avalanches; during each avalanche the grains comprising the
avalanche spontaneously stratify into a pair of layers through a "kink"
mechanism, with the small grains forming a sublayer underneath the layer of
large grains.Comment: 4 pages, 6 figures, http://polymer.bu.edu/~hmakse/Home.htm
Flower proteome: changes in protein spectrum during the advanced stages of rose petal development
Flowering is a unique and highly programmed process, but hardly anything is known about the developmentally regulated proteome changes in petals. Here, we employed proteomic technologies to study petal development in rose ( Rosa hybrida ). Using two-dimensional polyacrylamide gel electrophoresis, we generated stage-specific (closed bud, mature flower and flower at anthesis) petal protein maps with ca. 1,000 unique protein spots. Expression analyses of all resolved protein spots revealed that almost 30% of them were stage-specific, with ca. 90 protein spots for each stage. Most of the proteins exhibited differential expression during petal development, whereas only ca. 6% were constitutively expressed. Eighty-two of the resolved proteins were identified by mass spectrometry and annotated. Classification of the annotated proteins into functional groups revealed energy, cell rescue, unknown function (including novel sequences) and metabolism to be the largest classes, together comprising ca. 90% of all identified proteins. Interestingly, a large number of stress-related proteins were identified in developing petals. Analyses of the expression patterns of annotated proteins and their corresponding RNAs confirmed the importance of proteome characterization.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47485/1/425_2005_Article_1512.pd
Acute oxytocin improves memory and gaze following in male but not female nursery-reared infant macaques
Rationale: Exogenous oxytocin administration is widely reported to improve social cognition in human and nonhuman primate adults. Risk factors of impaired social cognition, however, emerge in infancy. Early interventions—when plasticity is greatest—are critical to reverse negative outcomes.
Objective: We tested the hypothesis that oxytocin may exert similar positive effects on infant social cognition, as in adults. To test this idea, we assessed the effectiveness of acute, aerosolized oxytocin on two foundational social cognitive skills: working memory (i.e., ability to briefly hold and process information) and social gaze (i.e., tracking the direction of others’ gaze) in 1-month-old nursery-reared macaque monkeys (Macaca mulatta). We did not predict sex differences, but we included sex as a factor in our analyses to test whether our effects would be generalizable across both males and females.
Results: In a double-blind, placebo-controlled design, we found that females were more socially skilled at baseline compared to males, and that oxytocin improved working memory and gaze following, but only in males.
Conclusions: These sex differences, while unexpected, may be due to interactions with gonadal steroids and may be relevant to sexually dimorphic disorders of social cognition, such as male-biased autism spectrum disorder, for which oxytocin has been proposed as a potential treatment. In sum, we report the first evidence that oxytocin may influence primate infant cognitive abilities. Moreover, these behavioral effects appear sexually dimorphic, highlighting the importance of considering sex differences. Oxytocin effects observed in one sex may not be generalizable to the other sex