17 research outputs found

    Judah Folkman, a pioneer in the study of angiogenesis

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    More than 30 years ago, Judah Folkman found a revolutionary new way to think about cancer. He postulated that in order to survive and grow, tumors require blood vessels, and that by cutting off that blood supply, a cancer could be starved into remission. What began as a revolutionary approach to cancer has evolved into one of the most exciting areas of scientific inquiry today. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases

    Dynamic dispatching priority setting in customer-oriented manufacturing environments

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    In today's competitive environment, customer-oriented view is essential in gaining sustainable competitive advantage. This study aims to reflect the customer-oriented view to production planning and control decisions. To this aim, a simulation optimization-based approach is developed for job shop systems with dynamic order arrivals. Product-type-based lot splitting is applied in order to improve the flow time, and machine-based dispatching rules are utilized for sublot scheduling to realize dynamic scheduling. Multiple customer segments with different importance weights and their expectations and penalties on order completion rate on due date, tardiness, and earliness are considered. A customer satisfaction-based objective function is defined. Customer-oriented dispatching rules are proposed in this study to ensure the prioritization of orders from the key customers in order fulfilling. In order to prevent customer losses by providing a balanced structure between the customer segments in terms of the satisfaction levels, weight setting functions that dynamically compute the weights in the proposed dispatching rules are proposed. It is aimed to determine the near-optimal values of the segment-based parameters of the related weight setting functions. To this aim, a differential evolution algorithm-based simulation optimization approach is proposed. To confirm its viability, the proposed approach is applied to a realistic job shop system
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