5 research outputs found
Medicina de FamĂlia do Primeiro ao Sexto Ano da Graduação MĂ©dica: Considerações sobre uma Proposta Educacional de Integração Curricular Escola-Serviço
Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5 59029 A/G Polymorphism
A panoramic view of the immune response to Trypanosoma cruzi infection
Chagas disease is a complex disorder in which the immunological response developed by the host plays a fundamental role, not only in the clearance of the parasite but also in the inflammatory status observed in specific affected tissues. Chagas disease has two phases, acute and chronic, the latter being established in those cases where treatment with currently available anti-parasitic drugs (Nifurtimox and Benznidazole) is either not applied or not effective. During the chronic phase, the disease may remain without any detectable symptoms for several decades, or progress toward cardiac, digestive, neurological forms, or even a combination of these alterations. The immune response developed in all of these conditions is flowery and comprises humoral and cellular components; however the clearance of the parasite is incomplete due to the multiple mechanisms that T. cruzi deploys in order to perpetuate itself within the host.Here, we make an extensive review of T. cruzi-host immune response interactions with special attention on human models, and also referring to the particular clinical scenario of etiological treatment in Chagas disease.Fil: Acevedo, Gonzalo RaĂşl. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de Investigaciones en IngenierĂa GenĂ©tica y BiologĂa Molecular "Dr. HĂ©ctor N. Torres"; ArgentinaFil: Girard, MagalĂ Celeste. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de Investigaciones en IngenierĂa GenĂ©tica y BiologĂa Molecular "Dr. HĂ©ctor N. Torres"; ArgentinaFil: Gomez, Karina Andrea. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Instituto de Investigaciones en IngenierĂa GenĂ©tica y BiologĂa Molecular "Dr. HĂ©ctor N. Torres"; Argentin