JRC QSAR Model Database: EURL ECVAM DataBase service on ALternative Methods to animal experimentation: Guideline for Authors and Editors

EURL ECVAM DataBase service on ALternative Methods to animal experimentation In the regulatory assessment of chemicals, Quantitative Structure-Activity Relationship (QSAR) models are playing an increasingly important role in predicting properties needed for hazard and risk assessment. The JRC QSAR Model Database provides information on the validity of QSAR models that have been submitted to the JRC. The database is intended to help to identify valid QSARs, e.g. for the registration and authorisation purposes of chemical substances within the context of REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (EC 1907/2006), a European Union regulation dated 18 December 2006. The QSAR Model Reporting Format (QMRF) is a harmonised template for summarising and reporting key information on QSAR models, including the results of any validation studies. The information is structured according to the OECD principles for the validation of QSAR models.JRC.F.3-Chemicals Safety and Alternative Method

JRC QSAR Model Database: EURL ECVAM DataBase service on ALternative Methods to animal experimentation: To promote the development and uptake of alternative and advanced methods in toxicology and biomedical sciences: SDF - STRUCTURE DATA FORMAT: How to create from SMILES

EURL ECVAM DataBase service on ALternative Methods to animal experimentation To promote the development and uptake of alternative and advanced methods in toxicology and biomedical sciences. This publication is a Tutorial by the Joint Research Centre (JRC), the European Commission’s science and knowledge service. It aims to provide user support. The scientific output expressed does not imply a policy position of the European Commission. Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use that might be made of this publication.JRC.F.3-Chemicals Safety and Alternative Method

Accelerating progress in the Replacement, Reduction and Refinement of animal testing through better knowledge sharing

In the context of the European Commission's Communication published in response to the European Citizens' Initiative "Stop Vivisection", Action 1 aimed to conduct an assessment of current technologies, information sources and networks from all relevant sectors with potential impact on the advancement of the refinement, reduction and replacement of animals used for scientific purposes (the "Three Rs"). The main objective of this study is to map knowledge sources relevant to the Three Rs, to examine how knowledge is being shared, and to identify possible gaps and opportunities to enhance knowledge sharing. An inventory of knowledge sources (KS) potentially relevant to the Three Rs used in the area of life sciences has been compiled which should be viewed as a snapshot of the current status of knowledge sources available (the supply), and as a starting point for further analysis of knowledge sharing strategies. A public survey was also conducted to complement this study (supply versus demand), and to inform on how to proceed effectively with any knowledge management strategy. The survey has revealed that many involved in this area consider that whilst access to relevant knowledge sources is adequate, there is a need for better coordination of the sources, as well as for the communication of information. Opportunities for face-to-face exchanges are highly valued and there is a firm call for more developments in education and training at professional, university and secondary school levels.JRC.F.3-Chemicals Safety and Alternative Method

ECICC: European Commission Initiative on Colorectal Cancer

This leaflet describes the European Commission Initiative on Colorectal Cancer (ECICC), a person-centred initiative to improve colorectal cancer care in Europe. The ECICC will develop evidence-based guidelines and a quality assurance scheme for healthcare services involved in the colorectal cancer care pathway.JRC.F.1-Health in Societ

ECIBC at a Glance: European Commission Initiative on Breast Cancer

This document is a brochure explaining the EICBC initiative to a middle-informed audience. ECIBC provides evidence based guidelines and a European Quality assurance scheme for breast cancer.JRC.F.1-Health in Societ

EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2013-April 2014)

The EURL ECVAM status report provides an update on the progress made in the development, validation and regulatory acceptance of alternative methods and approaches since the last report published in April 2013. It is informing on ongoing research and development activities, validation studies, peer reviews, recommendations, strategies and international acceptance of alternative methods and approaches. R&D activities are ongoing for the complex endpoints where the toxicological processes and the mechanistic understanding have not been sufficiently elucidated yet and for which 3Rs solutions are more difficult to find. On the other hand, good progress In the validation and regulatory acceptance is made in areas where non-animal alternative methods have been developed and validated and where the focus lies in an intelligent combination/ integration of the various non-animal approaches.JRC.I.5-Systems Toxicolog

Alternative methods for regulatory toxicology – a state-of-the-art review

This state-of-the art review is based on the final report of a project carried out by the European Commission’s Joint Research Centre (JRC) for the European Chemicals Agency (ECHA). The aim of the project was to review the state of the science of non-standard methods that are available for assessing the toxicological and ecotoxicological properties of chemicals. Non-standard methods refer to alternatives to animal experiments, such as in vitro tests and computational models, as well as animal methods that are not covered by current regulatory guidelines. This report therefore reviews the current scientific status of non-standard methods for a range of human health and ecotoxicological endpoints, and provides a commentary on the mechanistic basis and regulatory applicability of these methods. For completeness, and to provide context, currently accepted (standard) methods are also summarised. In particular, the following human health endpoints are covered: a) skin irritation and corrosion; b) serious eye damage and eye irritation; c) skin sensitisation; d) acute systemic toxicity; e) repeat dose toxicity; f) genotoxicity and mutagenicity; g) carcinogenicity; h) reproductive toxicity (including effects on development and fertility); i) endocrine disruption relevant to human health; and j) toxicokinetics. In relation to ecotoxicological endpoints, the report focuses on non-standard methods for acute and chronic fish toxicity. While specific reference is made to the information needs of REACH, the Biocidal Products Regulation and the Classification, Labelling and Packaging Regulation, this review is also expected to be informative in relation to the possible use of alternative and non-standard methods in other sectors, such as cosmetics and plant protection products.JRC.I.5-Systems Toxicolog

EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2015)

The EURL ECVAM status report provides an update on the progress made in the development, validation and regulatory acceptance of alternative methods and approaches and their dissemination since the last report published in June 2014. It is informing on ongoing research and development activities, validation studies, peer reviews, recommendations, strategies and regulatory/international acceptance of alternative methods and approaches and dissemination activities. R&D activities within large European or International consortia continued in toxicity areas where 3Rs solutions are more difficult to find due to the underlying complexity of the area. On the other hand, toxicity areas where promising non-animal approaches have been developed, their validation and regulatory acceptance/international adoption could be progressed. Particular emphasis was given to the best and most intelligent combination and integration of these different non-animal approaches to ultimately obtain the required information without resorting to animal testing.JRC.I.5-Systems Toxicolog

EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2016)

Replacement, Reduction and Refinement of animal testing is anchored in EU legislation. Alternative non-animal approaches facilitate a shift away from animal testing. Cell-based methods and computational technologies are integrated to translate molecular mechanistic understanding of toxicity into safety testing strategies.JRC.F.3-Chemicals Safety and Alternative Method

ECVAM's Database Service on Alternative Methods (DB-ALM) Online

ECVAM's Database service on ALternative Methods (Db-ALM) was established to achieve one of the principal objectives of ECVAM as required by the European Commission and Parliament. The year 2005 will see the public access to the entirely revised Internet version of the Db-ALM providing access to new information sectors, such as method summary descriptions and details on validation studies. Db-ALM provides its information as evaluated data sheets. So far, information is available for 21 topics mainly in the area of toxicity testing of chemicals. The current Internet version can refer about 4000 registered users from 65 countries.JRC.I.2-Validation of biomedical testing method