DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF IGURATIMOD IN BULK AND PHARMACEUTICAL DOSAGE FORM

Objective: The objective of the work was to develop and validate stability indicating HPTLC method for the estimation of Iguratimod. Methods: The method employed HPTLC aluminium pre-covered silica gel 60 GF254 plates (10 cm × 10 cm with 250 μm layer thickness) as stationary phase while the solvent system was n-Hexane: Ethyl Acetate (5:5 v/v) with densitometric scanning at 256 nm. Sample was applied as a band of 8 mm width using Camag 100 μl sample syringe (Hamilton, Switzerland) using a linomat 5 applicator (Camag, Switzerland). Migration distance was 80 mm. Further the sample was subjected for stress conditions under acid and base hydrolysis, oxidation, thermal, neutral and photolytic conditions. Method validation done according to ICH Q2 (R1) guidelines. Results: Retention factor (Rf) of the drug was 0.41±0.02. The linearity of the method was found to be within the concentration range of 200-1200 ng/band with R2= 0.983. Limit of detection and limit of quantification were found to be 34.69 and 105.12 ng/band respectively. The % mean recovery was found to be 100.38±0.83. Stress results showed that there is degradation in acid and base conditions but two degradant peaks were observed only under alkaline stress condition Conclusion: The developed method found to be accurate, simple and precise. Method is successfully employed for quantification of the drug under various stress conditions

Impact and Usage of Social Media in Business Sector during Covid-19 Pandemic

The Impact of covid-19 faced by whole world. The economic growth of all the countries is going down because of covid-19. In India, the covid-19 affected all the sectors but it mostly affected business sector. Social media is used in business sector, but during covid-19 pandemic situation social media is widely used in business sector for work effectively. The purpose of study is to determine the impact of social media on startup and growing business. The researcher wish to investigate how social Media influence on the growth of business and also to analyze which social media tools and application are used for effective work of business. Experiment were done on research data collected from the internet, Journal, Articles and personal prior knowledge. The result showed business sector are work or run effectively during pandemic situation. Most of business are used social media platform for example- Facebook, twitter, Instagram LinkedIn etc. Business sector are use social media platform for improving business both in quality and quantity. So, we conclude that, Business sector widely used social Media platform for effective and continuous work. This study is significant for Business Entrepreneur, Society, stakeholders, Government people and competitors. &nbsp

AN AUTONOMIC CLOUD ENVIRONMENT FOR HOSTING E-VOTING FOR CORPORATE INSTITUTIONS

ABSTRACT it poses, such as unequal access (digital divide), violation to secrecy and anonymity, alteration of the results of an election (because of malicious attacks, bad design/coding, or Procedural weaknesses). As in the case of corporate world, we have proposed the development of an autonomic system which helps in the conduction of the transparent voting process for the corporate companies. All the ve rification process, counting of votes and declaration of results will be automatic. Thus, creating a self-sufficient and secured system with the help of NFC. Further, this system will also provide a platform for rating of the products in the form of "like s". This will help in planning the product release and also help in predicting the market trends so that the maximum product sales can be achieved

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Not AvailablePearl millet (Pennisetum glaucum L.) is a C4 plant with high photosynthetic efficiency and dry matter production capacity. Pearl millet is widely cultivated in Rajasthan, Maharashtra, Gujarat, Uttar Pradesh and Haryana. It is mostly grown in Rainy (Kharif) season. Its grains are highly nutritious with high levels of metabolizable energy and protein. Utilization of different kinds of germplasm and breeding material is very critical in the diversification of cultivars. Being a cross pollinated crop, it provides very good opportunity for recombination and easy pollen flow, making hybrids more rewarding to the farming community. Identification of good maintainer (B) lines and Restorer (R) lines is of utmost importance to breed for hybrids. In this context, the present investigation was carried out at Centre on Rabi sorghum (ICAR-IIMR), Solapur during Kharif 2017 and the study consists of two sets of material viz., 56 B lines and 65 R lines. These lines were evaluated in a Randomized Block Design with two replications. To utilize large number of lines is difficult hence to bring the number to utilizable size cluster analysis is very useful. The variability in six quantitative traits such as Days to 50% flowering, Plant height, Panicle length, Panicle thickness, Grain yield/plant, Fodder yield/plant was studied. Maximum variation was found in Panicle exertion (B; CV=43.84, R; CV=38.48) followed by fodder yield per plant (B;CV=37.24, R; CV=37.54). All the six traits were used as variables in cluster analysis. In the present study four clusters were assigned a priori in both B and R lines. The frequency classes in the qualitative traits were studied to identify the common and rare types in total set. It was found that 75% of lines were of intermediate Spikelet density and synchrony of maturity, 85.3% were with good Seed Yield Potential and 50% with good Fodder Yield Potential. The promising lines belonging to different clusters are to be crossed to broaden the genetic base. Superior ones are hybridized with their counter A linesICA