PTTG1/securin modulates microtubule nucleation and cell migration

PTTG1 is associated with the cis face of the Golgi apparatus and the centrosome, forming a complex with proteins involved in microtubule nucleation. PTTG1 depletion produces a delay in centrosomal and noncentrosomal microtubule nucleation and causes defects in both cell polarization and migration