The large observatory for x-ray timing

Postprint (published version

Observing GRBs with the LOFT Wide Field Monitor

LOFT (Large Observatory For X-ray Timing) is one of the four candidate missions currently under assessment study for the M3 mission in ESAs Cosmic Vision program to be launched in 2024. LOFT will carry two instruments with prime sensitivity in the 2-30 keV range: a 10 m2 class large area detector (LAD) with a <1° collimated field of view and a wide field monitor (WFM) instrument. The WFM is based on the coded mask principle, and 5 camera units will provide coverage of more than 1/3 of the sky. The prime goal of the WFM is to detect transient sources to be observed by the LAD. With its wide field of view and good energy resolution of <500 eV, the WFM will be an excellent instrument for detecting and studying GRBs and X-ray flashes. The WFM will be able to detect ~150 gamma ray bursts per year, and a burst alert system will enable the distribution of ~100 GRB positions per year with a ~1 arcmin location accuracy within 30 s of the burst

Constraining Sterile Neutrino Warm Dark Matter with Chandra Observations of the Andromeda Galaxy

We use the Chandra unresolved X-ray emission spectrum from a 12'-28' (2.8-6.4 kpc) annular region of the Andromeda galaxy to constrain the radiative decay of sterile neutrino warm dark matter. By excising the most baryon-dominated, central 2.8 kpc of the galaxy, we reduce the uncertainties in our estimate of the dark matter mass within the field of view and improve the signal-to-noise ratio of prospective sterile neutrino decay signatures relative to hot gas and unresolved stellar emission. Our findings impose the most stringent limit on the sterile neutrino mass to date in the context of the Dodelson-Widrow model, m_s < 2.2 keV (95% C.L.). Our results also constrain alternative sterile neutrino production scenarios at very small active-sterile neutrino mixing angles.Comment: minor revisions, key results unchanged, accepted for publication in JCA

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Diabetes mellitus: pathophysiological changes and therap

Comparison of blind imaging performance of Fizeau and Michelson type arrays for a partially resolved object

This paper compares two well-known types of interferometer arrays for optical aperture synthesis. An analytical model for both types describes the expected output, in terms of photon counts. The goal is to characterize the performance of both types of array for blind imaging of a wide-field or extended object that would be partially resolved by a single elementary aperture. The spectrum of the source is assumed to be constant over the source and in time, but broad-banded. The light levels are such that only a few photons per pixel or bin are received. The simulated interferometer responses are discussed. The process of reconstructing the source from the ‘recorded’ responses is presented, but not discussed in this paper. It turns out that both types of interferometer are capable of imaging a partially resolved source with high spatial frequencies present all over the source.Imaging Science and TechnologyApplied Science