62 research outputs found

    Typical support and Sanov large deviations of correlated states

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    Discrete stationary classical processes as well as quantum lattice states are asymptotically confined to their respective typical support, the exponential growth rate of which is given by the (maximal ergodic) entropy. In the iid case the distinguishability of typical supports can be asymptotically specified by means of the relative entropy, according to Sanov's theorem. We give an extension to the correlated case, referring to the newly introduced class of HP-states.Comment: 29 pages, no figures, references adde

    Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise

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    SummaryAcylcarnitine metabolites have gained attention as biomarkers of nutrient stress, but their physiological relevance and metabolic purpose remain poorly understood. Short-chain carnitine conjugates, including acetylcarnitine, derive from their corresponding acyl-CoA precursors via the action of carnitine acetyltransferase (CrAT), a bidirectional mitochondrial matrix enzyme. We show here that contractile activity reverses acetylcarnitine flux in muscle, from net production and efflux at rest to net uptake and consumption during exercise. Disruption of this switch in mice with muscle-specific CrAT deficiency resulted in acetyl-CoA deficit, perturbed energy charge, and diminished exercise tolerance, whereas acetylcarnitine supplementation produced opposite outcomes in a CrAT-dependent manner. Likewise, in exercise-trained compared to untrained humans, post-exercise phosphocreatine recovery rates were positively associated with CrAT activity and coincided with dramatic shifts in muscle acetylcarnitine dynamics. These findings show acetylcarnitine serves as a critical acetyl buffer for working muscles and provide insight into potential therapeutic strategies for combatting exercise intolerance

    Complex Langevin: Etiology and Diagnostics of its Main Problem

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    The complex Langevin method is a leading candidate for solving the so-called sign problem occurring in various physical situations. Its most vexing problem is that in some cases it produces `convergence to the wrong limit'. In the first part of the paper we go through the formal justification of the method, identify points at which it may fail and identify a necessary and sufficient criterion for correctness. This criterion would, however, require checking infinitely many identities, and therefore is somewhat academic. We propose instead a truncation to the check of a few identities; this still gives a necessary criterion, but a priori it is not clear whether it remains sufficient. In the second part we carry out a detailed study of two toy models: first we identify the reasons why in some cases the method fails, second we test the efficiency of the truncated criterion and find that it works perfectly at least in the toy models studied.Comment: 39 pages, 15 figures; typos corrected and reference adde

    First Measurement of Z/gamma* Production in Compton Scattering of Quasi-real Photons

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    We report the first observation of Z/gamma* production in Compton scattering of quasi-real photons. This is a subprocess of the reaction e+e- to e+e-Z/gamma*, where one of the final state electrons is undetected. Approximately 55 pb-1 of data collected in the year 1997 at an e+e- centre-of-mass energy of 183 GeV with the OPAL detector at LEP have been analysed. The Z/gamma* from Compton scattering has been detected in the hadronic decay channel. Within well defined kinematic bounds, we measure the product of cross-section and Z/gamma* branching ratio to hadrons to be (0.9+-0.3+-0.1) pb for events with a hadronic mass larger than 60 GeV, dominated by (e)eZ production. In the hadronic mass region between 5 GeV and 60 GeV, dominated by (e)egamma* production, this product is found to be (4.1+-1.6+-0.6) pb. Our results agree with the predictions of two Monte Carlo event generators, grc4f and PYTHIA.Comment: 18 pages, LaTeX, 5 eps figures included, submitted to Physics Letters

    Experimental progress in positronium laser physics

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    Anxiety in sport: Why are findings contradictory?

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