861 research outputs found
Baryogenesis via lepton number violating scalar interactions
We study baryogenesis through lepton number violation in left-right symmetric
models. In these models the lepton number and CP violating interactions of the
triplet higgs scalars can give rise to lepton number asymmetry through
non-equilibrium decays of the triplet higgs and the right handed
neutrinos. This in turn generates baryon asymmetry during the electroweak
anomalous processes.Comment: 14 pages, UTPT-93-1
CASSETTE—clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: Study protocol for a randomised controlled trial
Background
Exotoxins are important virulence factors in Staphylococcus aureus. Clindamycin, a protein synthesis inhibitor antibiotic, is thought to limit exotoxin production and improve outcomes in severe S. aureus infections. However, randomised prospective data to support this are lacking.
Methods
An open-label, multicentre, randomised controlled trial (RCT) will compare outcome differences in severe S. aureus infection between standard treatment (flucloxacillin/cefazolin in methicillin-susceptible S. aureus; and vancomycin/daptomycin in methicillin-resistant S. aureus) and standard treatment plus an additional clindamycin given for 7 days. We will include a minimum of 60 participants (both adult and children) in the pilot study. Participants will be enrolled within 72 h of an index culture. Severe infections will include septic shock, necrotising pneumonia, or multifocal and non-contiguous skin and soft tissue/osteoarticular infections. Individuals who are immunosuppressed, moribund, with current severe diarrhoea or Clostridiodes difficile infection, pregnant, and those with anaphylaxis to β-lactams or lincosamides will be excluded.
The primary outcomes measure is the number of days alive and free (1 or 0) of systemic inflammatory response syndrome (SIRS) within the first 14 days post randomisation. The secondary outcomes measure will include all-cause mortality at 14, 42, and 90 days, time to resolution of SIRS, proportion with microbiological treatment failure, and rate of change of C-reactive protein over time. Impacts of inducible clindamycin resistance, strain types, methicillin susceptibility, and presence of various exotoxins will also be analysed.
Discussion
This study will assess the effect of adjunctive clindamycin on patient-centred outcomes in severe, toxin-mediated S. aureus infections. The pilot study will provide feasibility for a much larger RCT.
Trial registration
Australian New Zealand Clinical Trials Registry, ACTRN12617001416381p. Registered on 6 October 2017
Variational Approximations in a Path-Integral Description of Potential Scattering
Using a recent path integral representation for the T-matrix in
nonrelativistic potential scattering we investigate new variational
approximations in this framework. By means of the Feynman-Jensen variational
principle and the most general ansatz quadratic in the velocity variables --
over which one has to integrate functionally -- we obtain variational equations
which contain classical elements (trajectories) as well as quantum-mechanical
ones (wave spreading).We analyse these equations and solve them numerically by
iteration, a procedure best suited at high energy. The first correction to the
variational result arising from a cumulant expansion is also evaluated.
Comparison is made with exact partial-wave results for scattering from a
Gaussian potential and better agreement is found at large scattering angles
where the standard eikonal-type approximations fail.Comment: 35 pages, 3 figures, 6 tables, Latex with amsmath, amssymb; v2: 28
pages, EPJ style, misprints corrected, note added about correct treatment of
complex Gaussian integrals with the theory of "pencils", matches published
versio
SO(10) unified models and soft leptogenesis
Motivated by the fact that, in some realistic models combining SO(10) GUTs
and flavour symmetries, it is not possible to achieve the required baryon
asymmetry through the CP asymmetry generated in the decay of right-handed
neutrinos, we take a fresh look on how deep this connection is in SO(10). The
common characteristics of these models are that they use the see-saw with
right-handed neutrinos, predict a normal hierarchy of masses for the neutrinos
observed in oscillating experiments and in the basis where the right-handed
Majorana mass is diagonal, the charged lepton mixings are tiny.
In addition these models link the up-quark Yukawa matrix to the neutrino
Yukawa matrix Y^\nu with the special feature of Y^\nu_{11}-> 0 Using this
condition, we find that the required baryon asymmetry of the Universe can be
explained by the soft leptogenesis using the soft B parameter of the second
lightest right-handed neutrino whose mass turns out to be around 10^8 GeV. It
is pointed out that a natural way to do so is to use no-scale supergravity
where the value of B ~1 GeV is set through gauge-loop corrections.Comment: 26 pages, 2 figures. Added references, new appendix of a relevant fit
and improved comment
Protecting the primordial baryon asymmetry in the seesaw model compatible with WMAP and KamLAND
We require that the primordial baryon asymmetry is not washed out in the
seesaw model compatible with the recent results of WMAP and the neutrino
oscillation experiments including the first results of KamLAND. We find that
only the case of the normal neutrino mass hierarchy with an approximate
-symmetry satisfies the requirement. We further derive, depending on the
signs of neutrino mass eigenvalues, three types of neutrino mass matrixes,
where the values of each element are rather precisely fixed.Comment: 21pages; added reference
Relationship between dynamical heterogeneities and stretched exponential relaxation
We identify the dynamical heterogeneities as an essential prerequisite for
stretched exponential relaxation in dynamically frustrated systems. This
heterogeneity takes the form of ordered domains of finite but diverging
lifetime for particles in atomic or molecular systems, or spin states in
magnetic materials. At the onset of the dynamical heterogeneity, the
distribution of time intervals spent in such domains or traps becomes stretched
exponential at long time. We rigorously show that once this is the case, the
autocorrelation function of the renewal process formed by these time intervals
is also stretched exponential at long time.Comment: 8 pages, 4 figures, submitted to PR
Leptogenesis and Neutrino Oscillations Within A Predictive G(224)/SO(10)-Framework
A framework based on an effective symmetry that is either G(224)= SU(2)_L x
SU(2)_R xSU(4)^c or SO(10) has been proposed (a few years ago) that
successfully describes the masses and mixings of all fermions including
neutrinos, with seven predictions, in good accord with the data. Baryogenesis
via leptogenesis is considered within this framework by allowing for natural
phases (~ 1/20-1/2) in the entries of the Dirac and Majorana mass-matrices. It
is shown that the framework leads quite naturally, for both thermal as well as
non-thermal leptogenesis, to the desired magnitude for the baryon asymmetry.
This result is obtained in full accord with the observed features of the
atmospheric and solar neutrino oscillations, as well as with those of the quark
and charged lepton masses and mixings, and the gravitino-constraint. Hereby one
obtains a unified description of fermion masses, neutrino oscillations and
baryogenesis (via leptogenesis) within a single predictive framework.Comment: Efficiency factor updated, some clarifications and new references
added. 19 page
Big Bang Baryogenesis
An overview of baryogenesis in the early Universe is presented. The standard
big bang model including big bang nucleosynthesis and inflation is breifly
reviewed. Three basic models for baryogenesis will be developed: The
``standard" out-of-equilibrium decay model; the decay of scalar consensates
along flat directions in supersymmetric models; and lepto-baryogenesis, which
is the conversion of a lepton asymmetry into a baryon asymmetry via
non-perturbative electroweak interactions.Comment: 36 pages, LaTeX, UMN-TH-1249, Lectures given at the 33rd
International Winter School on Nuclear and Particle Physics, ``Matter Under
Extreme Conditions", Feb. 27 - March 5 1994, Schladming Austri
PREDICTING THE SUMMER TEMPERATURE OF SMALL STREAMS IN SOUTHWESTERN WISCONSIN 1
One of the biggest challenges in managing cold water streams in the Midwest is understanding how stream temperature is controlled by the complex interactions among meteorologic processes, channel geometry, and ground water inflow. Inflow of cold ground water, shade provided by riparian vegetation, and channel width are the most important factors controlling summer stream temperatures. A simple screening model was used to quantitatively evaluate the importance of these factors and guide management decisions. The model uses an analytical solution to the heat transport equation to predict steady-state temperature throughout a stream reach. The model matches field data from four streams in southwestern Wisconsin quite well (typically within 1°C) and helps explain the observed warming and cooling trends along each stream reach. The distribution of ground water inflow throughout a stream reach has an important influence on stream temperature, and springs are especially effective at providing thermal refuge for fish. Although simple, this model provides insight into the importance of ground water and the impact different management strategies, such as planting trees to increase shade, may have on summer stream temperature.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74032/1/j.1752-1688.2005.tb03714.x.pd
Coupling of acoustic cavitation with DEM-based particle solvers for modeling de-agglomeration of particle clusters in liquid metals
The aerospace and automotive industries are seeking advanced materials with low weight yet high strength and durability. Aluminum and magnesium-based metal matrix composites with ceramic micro- and nano-reinforcements promise the desirable properties. However, larger surface-area-to-volume ratio in micro- and especially nanoparticles gives rise to van der Waals and adhesion forces that cause the particles to agglomerate in clusters. Such clusters lead to adverse effects on final properties, no longer acting as dislocation anchors but instead becoming defects. Also, agglomeration causes the particle distribution to become uneven, leading to inconsistent properties. To break up clusters, ultrasonic processing may be used via an immersed sonotrode, or alternatively via electromagnetic vibration. This paper combines a fundamental study of acoustic cavitation in liquid aluminum with a study of the interaction forces causing particles to agglomerate, as well as mechanisms of cluster breakup. A non-linear acoustic cavitation model utilizing pressure waves produced by an immersed horn is presented, and then applied to cavitation in liquid aluminum. Physical quantities related to fluid flow and quantities specific to the cavitation solver are passed to a discrete element method particles model. The coupled system is then used for a detailed study of clusters’ breakup by cavitation
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