Cellular interaction with Si- and Iron-based nanoparticles for bio-imaging. A study of biocompatibility

The overall objective of BONSAI project (FP6, EC) is the development of ultrasensitive bio-imaging techniques based on novel multifunctional nanoparticles (NPs) with tailored optical and magnetic properties for visualizing complex cellular structures (in tissues and organs), receptors, tumour cells and masses. An important aspect to take into consideration involves the cellular responses to the impact of exogenous structures represented by NPs themselves. As a preliminary sign of reaction, we start to investigate the basic cytotoxicity

Advances in the preparation of novel functionalized nanoparticles for bioimaging

The EC BONSAI Project intends to develop multifunctional nanoparticles with tailored optical and/or magnetic properties for visualizing complex cellular structures (in tissues and organs), receptors, tumor cells and masses. In this framework, here we will report on recent advances on the preparation of luminescent silicon nanoparticles, magnetic iron oxide nanoparticles and Au nanorods for bio-imaging applications