29 research outputs found
EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial
More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369
Séquence N-terminale de la butyrophiline de la membrane des globules gras du lait de brebis
International audienc
Biological active factors in bovine milk and dairy byproducts: influence on cell culture
International audienc
Séparation rapide des protéines du lactosérum bovin par chromatographie liquide sur membranes à flux convectif, par chromatographie par perfusion, par chromatographie en lit continu et par électrophorèse capillaire
National audienc
Role of the O-phosphorine clusters in the interaction of the bovine milk às1-, á-, -caseins and the PP3 component with immobilized iron (III) ions
International audienc
Antibacterial activity of lactophoricin, a synthetic 23-residues peptide derived from the sequence of bovine milk component-3 of proteose peptone
International audienc
Multiple forms of equine alpha lactalbumin: evidence for N-glycosylated and deaminated forms
International audienc
Proteolysis in samples of quarter milk with varying somatic cell counts. 2. Components PP3 and beta-casein-1P (f29-105 and f29-107) of the proteose-peptone fraction
International audienc
Proteolysis of milk casein micelle and sodium caseinate in oil-in-water emulsions
International audienc