Particle and Antiparticle sectors in DSR1 and kappa-Minkowski space-time

In this paper we explore the problem of antiparticles in DSR1 and $\kappa$-Minkowski space-time following three different approaches inspired by the Lorentz invariant case: a) the dispersion relation, b) the Dirac equation in space-time and c) the Dirac equation in momentum space. We find that it is possible to define a map $S_{dsr}$ which gives the antiparticle sector from the negative frequency solutions of the wave equation. In $\kappa$-Poincar\'e, the corresponding map $S_{kp}$ is the antipodal mapping, which is different from $S_{dsr}$. The difference is related to the composition law, which is crucial to define the multiparticle sector of the theory. This discussion permits to show that the energy of the antiparticle in DSR is the positive root of the dispersion relation, which is consistent with phenomenological approaches.Comment: 15 pages, no figures, some references added, typos correcte

Characterization of a c-Rel inhibitor that mediates anticancer properties in hematologic malignancies by blocking NF-κB-controlled oxidative stress responses

NF-\u3baB plays a variety of roles in oncogenesis and immunity that may be beneficial for therapeutic targeting, but strategies to selectively inhibit NF-\u3baB to exert antitumor activity have been elusive. Here, we describe IT-901, a bioactive naphthalenethiobarbiturate derivative that potently inhibits the NF-\u3baB subunit c-Rel. IT-901 suppressed graft-versus-host disease while preserving graft-versus-lymphoma activity during allogeneic transplantation. Further preclinical assessment of IT-901 for the treatment of human B-cell lymphoma revealed antitumor properties in vitro and in vivo without restriction to NF-\u3baB-dependent lymphoma. This nondiscriminatory, antilymphoma effect was attributed to modulation of the redox homeostasis in lymphoma cells resulting in oxidative stress. Moreover, NF-\u3baB inhibition by IT-901 resulted in reduced stimulation of the oxidative stress response gene heme oxygenase-1, and we demonstrated that NF-\u3baB inhibition exacerbated oxidative stress induction to inhibit growth of lymphoma cells. Notably, IT-901 did not elicit increased levels of reactive oxygen species in normal leukocytes, illustrating its cancer selective properties. Taken together, our results provide mechanistic insight and preclinical proof of concept for IT-901 as a novel therapeutic agent to treat human lymphoid tumors and ameliorate graft-versus-host disease

Study of optical properties of Zn1−x_{\rm 1-x}Bex_{\rm x}Te mixed crystals by means of combined modulated IR radiometry and photoacoustics

Photothermal experiments using photoacoustic, IR radiometric and piezoelectric detection have been conducted on semiconductors and on metal samples as reference. For the metal samples the IR emissivity has been determined for differently treated surfaces by comparing the photoacoustic and the IR radiometry response. For semiconductor mixed crystals consisting of Zn$_{\rm 1-x}$Be$_{\rm x}$Te information on the composition dependence and depth variation of the IR optical properties has been deduced from combined measurements based on modulated IR radiometry and photoacoustics performed as a function of modulation frequency at one selected excitation wavelength. For the semiconductor mixed crystals, additionally, the optical absorption in the spectral range 350 nm to 900 nm has been determined