Modelling international conflict under conditions of state level economic and political uncertainty

Formal models of international conflict have tended to concentrate on change across the security dimension, assuming that the state level economic and political dimensions are constant. However, the conclusion of the Cold War suggests that over the long run these dimensions are not constant; indeed, the development of economic power, state level limits on defence expenditures, structural impediments to economic change, and several other 'constants' clearly do have an endogenous role in international conflict. This paper suggests one strategy for their inclusion as a causal factor in conflict modelling.Conflict, balance of power, economic and political uncertainty,

The theory of human development: A cross-cultural analysis

This article demonstrates that socioeconomic development, emancipative cultural change and democratization constitute a coherent syndrome of social progress – a syndrome whose common focus has not been properly specified by classical modernization theory. We specify this syndrome as ‘human development’, arguing that its three components have a common focus on broadening human choice. Socioeconomic development gives people the objective means of choice by increasing individual resources ; rising emancipative values strengthen people's subjective orientation towards choice; and democratization provides legal guarantees of choice by institutionalizing freedom rights . Analysis of data from the World Values Surveys demonstrates that the linkage between individual resources, emancipative values and freedom rights is universal in its presence across nations, regions and cultural zones; that this human development syndrome is shaped by a causal effect of individual resources and emancipative values on freedom rights; and that this effect operates through its impact on elite integrity , as the factor which makes freedom rights effective.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74505/1/1475-6765.00086.pd

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death