18 research outputs found

    Modified Langevin approach for a stochastic calcium puff model

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    National Institutes of Health USA [GM65830]; National Natural Science Foundation of China [30970970]In many cell types, intracellular calcium is released from internal stores through calcium release channels. Because these channels are distributed in clusters with a few tens of channels, the clusters show a strongly stochastic open and close dynamics, resulting in noisy localized Ca(2+) signals called puffs. Using the Li-Rinzel model we compare the stochastic channel simulations for the Markov method and three different Langevin approaches. We suggest that a modified Langevin approach should be considered in order to more accurately simulate Markov channel noise for puff dynamics
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