283 research outputs found
Directional vortex motion guided by artificially induced mesoscopic potentials
Rectangular pinning arrays of Ni dots define a potential landscape for vortex
motion in Nb films. Magnetotransport experiments in which two in-plane
orthogonal electrical currents are injected simultaneously allow selecting the
direction and magnitude of the Lorentz force on the vortex-lattice, thus
providing the angular dependence of the vortex motion. The background
dissipation depends on angle at low magnetic fields, which is progressively
smeared out with increasing field. The periodic potential locks in the vortex
motion along channeling directions. Because of this, vortex-lattice direction
of motion is up to 85o away from the applied Lorentz force direction.Comment: PDF file includes figure
Association of FCGR3A and FCGR3B haplotypes with rheumatoid arthritis and primary Sjögren's syndrome [POSTER PRESENTATION]
Background
Rheumatoid arthritis (RA) is an autoimmune disease that is thought to arise from a complex interaction between multiple genetic factors and environmental triggers. We have previously demonstrated an association between a Fc gamma receptor (FcγR) haplotype and RA in a cross-sectional cohort of RA patients. We have sought to confirm this association in an inception cohort of RA patients and matched controls. We also extended our study to investigate a second autoanti-body associated rheumatic disease, primary Sjögren's syndrome (PSS).
Methods
The FCGR3A-158F/V and FCGR3B-NA1/NA2 functional polymorphisms were examined for association in an inception cohort of RA patients (n = 448), and a well-characterised PSS cohort (n = 83) from the United Kingdom. Pairwise disequilibrium coefficients (D') were calculated in 267 Blood Service healthy controls. The EHPlus program was used to estimate haplotype frequencies for patients and controls and to determine whether significant linkage disequilibrium was present. A likelihood ratio test is performed to test for differences between the haplotype frequencies in cases and controls. A permutation procedure implemented in this program enabled 1000 permutations to be performed on all haplotype associations to assess significance.
Results
There was significant linkage disequilibrium between FCGR3A and FCGR3B (D' = -0.445, P = 0.001). There was no significant difference in the FCGR3A or FCGR3B allele or genotype frequencies in the RA or PSS patients compared with controls. However, there was a significant difference in the FCGR3A-FCGR3B haplotype distributions with increased homozygosity for the FCGR3A-FCGR3B 158V-NA2 haplotype in both our inception RA cohort (odds ratio = 2.15, 95% confidence interval = 1.1–4.2 P = 0.027) and PSS (odds ratio = 2.83, 95% confidence interval = 1.0–8.2, P = 0.047) compared with controls. The reference group for these analyses comprised individuals who did not possess a copy of the FCGR3A-FCGR3B 158V-NA2 haplotype.
Conclusions
We have confirmed our original findings of association between the FCGR3A-FCGR3B 158V-NA2 haplotype and RA in a new inception cohort of RA patients. This suggests that there may be an RA-susceptibility gene at this locus. The significant increased frequency of an identical haplotype in PSS suggests the FcÎłR genetic locus may contribute to the pathogenesis of diverse autoantibody-mediated rheumatic diseases
Temperature dependence and mechanisms for vortex pinning by periodic arrays of Ni dots in Nb films
Pinning interactions between superconducting vortices in Nb and magnetic Ni
dots were studied as a function of current and temperature to clarify the
nature of pinning mechanisms. A strong current dependence is found for a square
array of dots, with a temperature dependent optimum current for the observation
of periodic pinning, that decreases with temperature as (1-T/Tc)3/2. This same
temperature dependence is found for the critical current at the first matching
field with a rectangular array of dots. The analysis of these results allows to
narrow the possible pinning mechanisms to a combination of two: the interaction
between the vortex and the magnetic moment of the dot and the proximity effect.
Moreover, for the rectangular dot array, the temperature dependence of the
crossover between the low field regime with a rectangular vortex lattice to the
high field regime with a square configuration has been studied. It is found
that the crossover field increases with decreasing temperature. This dependence
indicates a change in the balance between elastic and pinning energies,
associated with dynamical effects of the vortex lattice in the high field
range.Comment: 12 text pages (revtex), 6 figures (1st jpeg, 2nd-6th postscript)
accepted in Physical Review
Superconducting Vortices and Elliptical Ferromagnetic Textures
In this article an analytical and numerical study of superconducting thin
film with ferromagnetic textures of elliptical geometries in close proximity is
presented. The screening currents induced in the superconductor due to the
magnetic texture are calculated. Close to the superconducting transition
temperature the spontaneous creation of superconducting vortices becomes
energy favorable depending on the value of the magnetization and the
geometrical quantities of the magnetic texture. The creation of vortices by
elliptic dots is more energy favorable than those created by circular ones. The
superconductor covered by elliptic dots array exhibits anisotropic transport
properties.Comment: 4 pages, 5figure
Transverse Phase Locking for Vortex Motion in Square and Triangular Pinning Arrays
We analyze transverse phase locking for vortex motion in a superconductor
with a longitudinal DC drive and a transverse AC drive. For both square and
triangular arrays we observe a variety of fractional phase locking steps in the
velocity versus DC drive which correspond to stable vortex orbits. The locking
steps are more pronounced for the triangular arrays which is due to the fact
that the vortex motion has a periodic transverse velocity component even for
zero transverse AC drive. All the steps increase monotonically in width with AC
amplitude. We confirm that the width of some fractional steps in the square
arrays scales as the square of the AC driving amplitude. In addition we
demonstrate scaling in the velocity versus applied DC driving curves at
depinning and on the main step, similar to that seen for phase locking in
charge-density wave systems. The phase locking steps are most prominent for
commensurate vortex fillings where the interstitial vortices form symmetrical
ground states. For increasing temperature, the fractional steps are washed out
very quickly, while the main step gains a linear component and disappears at
melting. For triangular pinning arrays we again observe transverse phase
locking, with the main and several of the fractional step widths scaling
linearly with AC amplitude.Comment: 10 pages, 14 postscript figure
Phase-Locking of Vortex Lattices Interacting with Periodic Pinning
We examine Shapiro steps for vortex lattices interacting with periodic
pinning arrays driven by AC and DC currents. The vortex flow occurs by the
motion of the interstitial vortices through the periodic potential generated by
the vortices that remain pinned at the pinning sites. Shapiro steps are
observed for fields B_{\phi} < B < 2.25B_{\phi} with the most pronouced steps
occuring for fields where the interstitial vortex lattice has a high degree of
symmetry. The widths of the phase-locked current steps as a function of the
magnitude of the AC driving are found to follow a Bessel function in agreement
with theory.Comment: 5 pages 5 postscript figure
Vortex Pinball Under Crossed AC Drives in Superconductors with Periodic Pinning Arrays
Vortices driven with both a transverse and a longitudinal AC drive which are
out of phase are shown to exhibit a novel commensuration-incommensuration
effect when interacting with periodic substrates. For different AC driving
parameters, the motion of the vortices forms commensurate orbits with the
periodicity of the pinning array. When the commensurate orbits are present,
there is a finite DC critical depinning threshold, while for the incommensurate
phases the vortices are delocalized and the DC depinning threshold is absent.Comment: 4 pages, 4 postscript figure
Commensurate and Incommensurate Vortex Lattice Melting in Periodic Pinning Arrays
We examine the melting of commensurate and incommensurate vortex lattices
interacting with square pinning arrays through the use of numerical
simulations. For weak pinning strength in the commensurate case we observe an
order-order transition from a commensurate square vortex lattice to a
triangular floating solid phase as a function of temperature. This floating
solid phase melts into a liquid at still higher temperature. For strong pinning
there is only a single transition from the square pinned lattice to the liquid
state. For strong pinning in the incommensurate case, we observe a multi-stage
melting in which the interstitial vortices become mobile first, followed by the
melting of the entire lattice, consistent with recent imaging experiments. The
initial motion of vortices in the incommensurate phase occurs by an exchange
process of interstitial vortices with vortices located at the pinning sites. We
have also examined the vortex melting behavior for higher matching fields and
find that a coexistence of a commensurate pinned vortex lattice with an
interstitial vortex liquid occurs while at higher temperatures the entire
vortex lattice melts. For triangular arrays at incommensurate fields higher
than the first matching field we observe that the initial vortex motion can
occur through a novel correlated ring excitation where a number of vortices can
rotate around a pinned vortex. We also discuss the relevance of our results to
recent experiments of colloidal particles interacting with periodic trap
arrays.Comment: 8 figure
Vortex states in 2D superconductor at high magnetic field in a periodic pinning potential
The effect of a periodic pinning array on the vortex state in a 2D
superconductor at low temperatures is studied within the framework of the
Ginzburg-Landau approach. It is shown that attractive interaction of vortex
cores to a commensurate pin lattice stabilizes vortex solid phases with long
range positional order against violent shear fluctuations. Exploiting a simple
analytical method, based on the Landau orbitals description, we derive a rather
detailed picture of the low temperatures vortex state phase diagram. It is
predicted that for sufficiently clean samples application of an artificial
periodic pinning array would enable one to directly detect the intrinsic shear
stiffness anisotropy characterizing the ideal vortex lattice.Comment: 8 pages, 5 figure
Anisotropic vortex pinning in superconductors with a square array of rectangular submicron holes
We investigate vortex pinning in thin superconducting films with a square
array of rectangular submicron holes ("antidots"). Two types of antidots are
considered: antidots fully perforating the superconducting film, and "blind
antidots", holes that perforate the film only up to a certain depth. In both
systems, we observe a distinct anisotropy in the pinning properties, reflected
in the critical current Ic, depending on the direction of the applied
electrical current: parallel to the long side of the antidots or perpendicular
to it. Although the mechanism responsible for the effect is very different in
the two systems, they both show a higher critical current and a sharper
IV-transition when the current is applied along the long side of the
rectangular antidots
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