3 research outputs found
Leptogenesis and rescattering in supersymmetric models
The observed baryon asymmetry of the Universe can be due to the
violating decay of heavy right handed (s)neutrinos. The amount of the asymmetry
depends crucially on their number density. If the (s)neutrinos are generated
thermally, in supersymmetric models there is limited parameter space leading to
enough baryons. For this reason, several alternative mechanisms have been
proposed. We discuss the nonperturbative production of sneutrino quanta by a
direct coupling to the inflaton. This production dominates over the
corresponding creation of neutrinos, and it can easily (i.e. even for a rather
small inflaton-sneutrino coupling) lead to a sufficient baryon asymmetry. We
then study the amplification of MSSM degrees of freedom, via their coupling to
the sneutrinos, during the rescattering phase which follows the nonperturbative
production. This process, which mainly influences the (MSSM) flat
directions, is very efficient as long as the sneutrinos quanta are in the
relativistic regime. The rapid amplification of the light degrees of freedom
may potentially lead to a gravitino problem. We estimate the gravitino
production by means of a perturbative calculation, discussing the regime in
which we expect it to be reliable.Comment: (20 pages, 6 figures), references added, typos corrected. Final
version in revte
Nonperturbative production of massless scalars during inflation and generation of gravitational waves
Cold agglutinin disease revisited: a multinational, observational study of 232 patients
We retrospectively studied 232 patients with cold agglutinin disease (CAD) at 24 centers in 5 countries. In Norway and a northern region of Italy, the study was close to being population-based. For the first time, we demonstrate fourfold differences between cold and warmer climates regarding prevalence (20 vs 5 cases/million) and incidence (1.9 vs 0.48 cases/million per year). Mean baseline hemoglobin level was 9.3 g/dL, but 27% had hemoglobin <8 g/dL. Identification of typical features of CAD-associated lymphoproliferative disorder in the bone marrow was greatly increased by centralized biopsy assessment. CAD seems to be associated with a slightly increased risk of venous thrombosis. This work includes a follow-up study of therapies, focusing on the long-term outcomes of the rituximab plus bendamustine and rituximab plus fludarabine regimens. Rituximab plus bendamustine therapy resulted in responses in 35 (78%) of 45 patients; 24 (53%) achieved complete response. Interestingly, these rates were still higher than observed in the original (2017) prospective trial, and we also found a shift toward deeper responses with time. This is explained by the prolonged time to response seen in many patients, probably related to long-lived plasma cells. In patients responding to rituximab-bendamustine, median response duration was not reached after 88 months, and estimated 5-year sustained remission was 77%. The regimen appeared safe regarding late-occurring malignancies. Rituximab plus fludarabine therapy seems to carry a higher risk of long-term adverse effects