1,412 research outputs found
Study of the dependence of 198Au half-life on source geometry
We report the results of an experiment to determine whether the half-life of
\Au{198} depends on the shape of the source. This study was motivated by recent
suggestions that nuclear decay rates may be affected by solar activity, perhaps
arising from solar neutrinos. If this were the case then the -decay
rates, or half-lives, of a thin foil sample and a spherical sample of gold of
the same mass and activity could be different. We find for \Au{198},
, where
is the mean half-life. The maximum neutrino flux at the sample in our
experiments was several times greater than the flux of solar neutrinos at the
surface of the Earth. We show that this increase in flux leads to a significant
improvement in the limits that can be inferred on a possible solar contribution
to nuclear decays.Comment: 5 pages, 1 figur
Neutron beam test of CsI crystal for dark matter search
We have studied the response of Tl-doped and Na-doped CsI crystals to nuclear
recoils and 's below 10 keV. The response of CsI crystals to nuclear
recoil was studied with mono-energetic neutrons produced by the
H(p,n)He reaction. This was compared to the response to Compton
electrons scattered by 662 keV -ray. Pulse shape discrimination between
the response to these 's and nuclear recoils was studied, and quality
factors were estimated. The quenching factors for nuclear recoils were derived
for both CsI(Na) and CsI(Tl) crystals.Comment: 21pages, 14figures, submitted to NIM
Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age-A nd combination-specific phenotypic profiles in Drosophila
A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this expansion is typically hundreds to thousands of repeat units in length. Repeat associated non-AUG translation of the expansion leads to the formation of toxic, pathological Dipeptide-Repeat Proteins (DPRs). To date there remains a lack of in vivo models expressing C9orf72 related DPRs with a repeat length of more than a few hundred repeats. As such our understanding of how physiologically relevant repeat length DPRs effect the nervous system in an ageing in vivo system remains limited. In this study we generated Drosophila models expressing DPRs over 1000 repeat units in length, a known pathological length in humans. Using these models, we demonstrate each DPR exhibits a unique, age-dependent, phenotypic and pathological profile. Furthermore, we show co-expression of specific DPR combinations leads to distinct, age-dependent, phenotypes not observed through expression of single DPRs. We propose these models represent a unique, in vivo, tool for dissecting the molecular mechanisms implicated in disease pathology, opening up new avenues in the study of both MND and FTD
Power Spectrum Analysis of Physikalisch-Technische Bundesanstalt Decay-Rate Data: Evidence for Solar Rotational Modulation
Evidence for an anomalous annual periodicity in certain nuclear decay data
has led to speculation concerning a possible solar influence on nuclear
processes. We have recently analyzed data concerning the decay rates of Cl-36
and Si-32, acquired at the Brookhaven National Laboratory (BNL), to search for
evidence that might be indicative of a process involving solar rotation.
Smoothing of the power spectrum by weighted-running-mean analysis leads to a
significant peak at frequency 11.18/yr, which is lower than the equatorial
synodic rotation rates of the convection and radiative zones. This article
concerns measurements of the decay rates of Ra-226 acquired at the
Physikalisch-Technische Bundesanstalt (PTB) in Germany. We find that a similar
(but not identical) analysis yields a significant peak in the PTB dataset at
frequency 11.21/yr, and a peak in the BNL dataset at 11.25/yr. The change in
the BNL result is not significant since the uncertainties in the BNL and PTB
analyses are estimated to be 0.13/yr and 0.07/yr, respectively. Combining the
two running means by forming the joint power statistic leads to a highly
significant peak at frequency 11.23/yr. We comment briefly on the possible
implications of these results for solar physics and for particle physics.Comment: 15 pages, 13 figure
Arthropathy and cutaneous manifestations in a 28-year-old patient with cystic fibrosis
We report on a 28-year-old man with known cystic fibrosis who presented with pain and cutaneous nodules in the elbow joints. His symptoms had appeared episodically in the previous months, they were always self-limiting, and independent of pulmonary exacerbations. A radiograph of the joints was unremarkable. These findings fit well with a special form of CF-related arthritis. As in the case of classical CF arthritis, the treatment to be considered is, in particular, symptomatic administration of non-steroidal anti-inflammatory drugs and possibly glucocorticoids. Also under discussion as a further possibility is the use of antibiotics. Our patient has always refused medication. The condition again proved to be self-limiting. In contrast to the classical form of CF arthritis, the special form is not associated with either joint swelling or local warmth. In the presence of arthritic symptoms in CF patients, consideration must always be given to a hypertrophic pulmonary osteoarthropathy. The latter, however, shows typical radiological changes and is exacerbated by lung infections. The presence of arthritic pathologies in a patient with CF further underscores the fact that CF is a multiorgan morbid condition
Impact of alcohol use disorder severity on human immunodeficiency virus (HIV) viral suppression and CD4 count in three international cohorts of people with HIV.
Alcohol use has been linked to worse human immunodeficiency virus (HIV) immunologic/virologic outcomes, yet few studies have explored the effects of alcohol use disorder (AUD). This study assessed whether AUD severity is associated with HIV viral suppression and CD4 count in the three cohorts of the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium.
People with HIV (PWH) in Uganda (n = 301), Russia (n = 400), and Boston (n = 251), selected in-part based on their alcohol use, were included in analyses. Logistic and linear regressions were used to assess the cross-sectional associations between AUD severity (number of DSM-5 diagnostic criteria) and (1) HIV viral suppression, and (2) CD4 count (cells/mm <sup>3</sup> ) adjusting for covariates. Analyses were conducted separately by site.
The proportion of females was 51% (Uganda), 34% (Russia), and 33% (Boston); mean age (SD) was 40.7 (9.6), 38.6 (6.3), and 52.1 (10.5), respectively. All participants in Uganda and all but 27% in Russia and 5% in Boston were on antiretroviral therapy. In Uganda, 32% met criteria for AUD, 92% in Russia, and 43% in Boston. The mean (SD) number of AUD criteria was 1.6 (2.4) in Uganda, 5.6 (3.3) in Russia, and 2.4 (3.1) in Boston. Most participants had HIV viral suppression (Uganda 92%, Russia 57%, Boston 87%); median (IQR) CD4 count was 673 (506, 866), 351 (201, 542), and 591 (387, 881), respectively. In adjusted models, there were no associations between AUD severity and HIV viral suppression: adjusted odds ratios (AOR) (95%CI) per 1 additional AUD criterion in Uganda was 1.08 (0.87, 1.33); Russia 0.98 (0.92, 1.04); and Boston 0.95 (0.84, 1.08) or CD4 count: mean difference (95%CI) per 1 additional criterion: 5.78 (-7.47, 19.03), -3.23 (-10.91, 4.44), and -8.18 (-24.72, 8.35), respectively.
In three cohorts of PWH, AUD severity was not associated with HIV viral suppression or CD4 count. PWH with AUD in the current era of antiretroviral therapy can achieve virologic control
First limit on WIMP cross section with low background CsI(Tl) crystal detector
The Korea Invisible Mass Search (KIMS) collaboration has been carrying out
WIMP search experiment with CsI(T)crystal detectors at the YanYang
Underground Laboratory. A successful reduction of the internal background of
the crystal is done and a good pulse shape discrimination is achieved. We
report the first result on WIMP search obtained with 237 kgdays data
using one full-size CsI(T)crystal of 6.6 kg mass.Comment: 16 pages, 9 figures, submitted to Physics Letters
The Kuiper Belt and Other Debris Disks
We discuss the current knowledge of the Solar system, focusing on bodies in
the outer regions, on the information they provide concerning Solar system
formation, and on the possible relationships that may exist between our system
and the debris disks of other stars. Beyond the domains of the Terrestrial and
giant planets, the comets in the Kuiper belt and the Oort cloud preserve some
of our most pristine materials. The Kuiper belt, in particular, is a
collisional dust source and a scientific bridge to the dusty "debris disks"
observed around many nearby main-sequence stars. Study of the Solar system
provides a level of detail that we cannot discern in the distant disks while
observations of the disks may help to set the Solar system in proper context.Comment: 50 pages, 25 Figures. To appear in conference proceedings book
"Astrophysics in the Next Decade
Comparing Implicit, Differential, Dimensional and BPHZ Renormalisation
We compare a momentum space implicit regularisation (IR) framework with other
renormalisation methods which may be applied to dimension specific theories,
namely Differential Renormalisation (DfR) and the BPHZ formalism. In
particular, we define what is meant by minimal subtraction in IR in connection
with DfR and dimensional renormalisation (DR) .We illustrate with the
calculation of the gluon self energy a procedure by which a constrained version
of IR automatically ensures gauge invariance at one loop level and handles
infrared divergences in a straightforward fashion. Moreover, using the
theory setting sun diagram as an example and comparing explicitly
with the BPHZ framework, we show that IR directly displays the finite part of
the amplitudes. We then construct a parametrization for the ambiguity in
separating the infinite and finite parts whose parameter serves as
renormalisation group scale for the Callan-Symanzik equation. Finally we argue
that constrained IR, constrained DfR and dimensional reduction are equivalent
within one loop order.Comment: 21 pages, 2 figures, late
Electroweak Radiative Corrections to Neutral-Current Drell-Yan Processes at Hadron Colliders
We calculate the complete electroweak O(alpha) corrections to pp, pbar p ->
l+l- X (l=e, mu) in the Standard Model of electroweak interactions. They
comprise weak and photonic virtual one-loop corrections as well as real photon
radiation to the parton-level processes q bar q -> gamma,Z -> l+l-. We study in
detail the effect of the radiative corrections on the l+l- invariant mass
distribution, the cross section in the Z boson resonance region, and on the
forward-backward asymmetry, A_FB, at the Fermilab Tevatron and the CERN Large
Hadron Collider. The weak corrections are found to increase the Z boson cross
section by about 1%, but have little effect on the forward-backward asymmetry
in the Z peak region. Threshold effects of the W box diagrams lead to
pronounced effects in A_FB at m(l+l-) approx 160 GeV which, however, will be
difficult to observe experimentally. At high di-lepton invariant masses, the
non-factorizable weak corrections are found to become large.Comment: Revtex3 file, 39 pages, 2 tables, 12 figure
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