3,421 research outputs found
Pathogenesis of leukoaraiosis : a review
Changes in the cerebral hemispheric white matter, detectable with increasing frequency by modern neuroimaging methods, are associated with aging and conceivably may contribute to the development of specific cognitive deficits. The pathogenesis of these cerebral white matter abnormalities (sometimes described as leukoaraiosis) is unknown. This review evaluates the available evidence in support of the hypothesis that the etiology of leukoaraiosis is related to a specific type of cerebral ischemia and highlights mechanisms by which ischemic injury to the brain may induce selected structural alterations limited to the cerebral white matter. Summary of Review The review is based on the critical analysis of over 100 publications (most appearing in the last decade) dealing with the anatomy and physiology of the arterial circulation to the cerebral white matter and with the pathogenesis of leukoaraiosis.
Conclusions A significant number of clues support the hypothesis that some types of leukoaraiosis may be the result of ischemic injury to the brain. Structural changes affecting the small intraparenchymal cerebral arteries and arterioles that are associated with aging and with stroke risk factors, altered cerebral blood flow autoregulation, and the conditions created by the unique arterial blood supply of the hemispheric white matter each seem to contribute to the development of leukoaraiosis. To the best of our ability to interpret current information, the type of ischemic injury that is most likely responsible for these while matter changes involves transient repeated events characterized by moderate drops in regional cerebral blood flow that induce an incomplete form of infarction. This hypothesis could be tested in appropriate experimental models
Physical performance and physical activity in older adults: associated but separate domains of physical function in old age.
Background: Physical Function Is A Crucial Factor In The Prevention And Treatment Of Health Conditions In Older Adults And Is Usually Measured Objectively With Physical Performance Tests And/or Physical Activity Monitoring. Objective: To Examine Whether 1) Physical Performance (PP) And Physical Activity (PA) Constitute Separate Domains Of Physical Function; 2) Differentiation Of PA Classes Is More Informative Than Overall PA. Design: Cross-Sectional Study To Explore The Relationships Within And Among PP And PA Measures. Methods In 49 Older Participants (83±7 Years; M±SD), Performance-based Tests Were Conducted And PA Was Measured For One Week. Activity Monitor Data Were Reduced In Terms Of Duration, Periods, And Mean Duration Of Periods Of Lying, Sitting, Standing And Locomotion. The Relation Between And Within PP Scores And PA Outcomes Were Analysed Using Rank Order Correlation And Factor Analysis. Results: Factor Structure After Varimax Rotation Revealed Two Orthogonal Factors Explaining 78% Of The Variance In The Data: One Comprising All PA Variables And One Comprising All PP Variables. PP Scores Correlated Moderately With PA In Daily Life. Differentiation Of Activity Types And Quantification Of Their Duration, Intensity And Frequency Of Occurrence Provided Stronger Associations With PP, As Compared To A Single Measure Of Acceleration Expressing Overall PA. Limitations: For Independent Validation, The Conclusions About The Validity Of The Presented Conceptual Framework And Its Clinical Implications Need To Be Confirmed In Other Studies. Conclusions: PP And PA Represent Associated But Separate Domains Of Physical Function, Suggesting That An Improvement Of PP Does Not Automatically Imply An Increase Of PA, I.e. A Change To A More Active Lifestyle. Differentiation Of Activity Classes In The Analysis Of PA Provides More Insights Into PA And Its Association With PP Than Using A Single Overall Measure Of Acceleration
Comparison of local pole assignment methods
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76770/1/AIAA-20171-818.pd
Phenomenological constraints on Lemaitre-Tolman-Bondi cosmological inhomogeneities from solar system dynamics
We, first, analytically work out the long-term, i.e. averaged over one
orbital revolution, perturbations on the orbit of a test particle moving in a
local Fermi frame induced therein by the cosmological tidal effects of the
inhomogeneous Lemaitre-Tolman-Bondi (LTB) model. The LTB solution has recently
attracted attention, among other things, as a possible explanation of the
observed cosmic acceleration without resorting to dark energy. Then, we
phenomenologically constrain both the parameters K_1 = -\ddot R/R and K_2 =
-\ddot R^'/R^' of the LTB metric in the Fermi frame by using different kinds of
solar system data. The corrections to the standard
Newtonian/Einsteinian precessions of the perihelia of the inner planets
recently estimated with the EPM ephemerides, compared to our predictions for
them, yield K_1 = (4+8) 10^-26 s^-2, K_2 = (3+7) 10^-23 s^-2. The residuals of
the Cassini-based Earth-Saturn range, compared with the numerically integrated
LTB range signature, allow to obtain K_1/2 = 10^-27 s^-2. The LTB-induced
distortions of the orbit of a typical object of the Oort cloud with respect to
the commonly accepted Newtonian picture, based on the observations of the comet
showers from that remote region of the solar system, point towards K_1/2 <=
10^-30-10^-32 s^-2. Such figures have to be compared with those inferred from
cosmological data which are of the order of K1 \approx K2 = -4 10^-36 s^-2.Comment: LaTex2e, 18 pages, 3 tables, 3 figures. Minor changes. Reference
added. Accepted by Journal of Cosmology and Astroparticle Physics (JCAP
Power Spectrum Analysis of Physikalisch-Technische Bundesanstalt Decay-Rate Data: Evidence for Solar Rotational Modulation
Evidence for an anomalous annual periodicity in certain nuclear decay data
has led to speculation concerning a possible solar influence on nuclear
processes. We have recently analyzed data concerning the decay rates of Cl-36
and Si-32, acquired at the Brookhaven National Laboratory (BNL), to search for
evidence that might be indicative of a process involving solar rotation.
Smoothing of the power spectrum by weighted-running-mean analysis leads to a
significant peak at frequency 11.18/yr, which is lower than the equatorial
synodic rotation rates of the convection and radiative zones. This article
concerns measurements of the decay rates of Ra-226 acquired at the
Physikalisch-Technische Bundesanstalt (PTB) in Germany. We find that a similar
(but not identical) analysis yields a significant peak in the PTB dataset at
frequency 11.21/yr, and a peak in the BNL dataset at 11.25/yr. The change in
the BNL result is not significant since the uncertainties in the BNL and PTB
analyses are estimated to be 0.13/yr and 0.07/yr, respectively. Combining the
two running means by forming the joint power statistic leads to a highly
significant peak at frequency 11.23/yr. We comment briefly on the possible
implications of these results for solar physics and for particle physics.Comment: 15 pages, 13 figure
Dynamics of tachyonic preheating after hybrid inflation
We study the instability of a scalar field at the end of hybrid inflation,
using both analytical techniques and numerical simulations. We improve previous
studies by taking the inflaton field fully into account, and show that the
range of unstable modes depends sensitively on the velocity of the inflaton
field, and thereby on the Hubble rate, at the end of inflation. If topological
defects are formed, their number density is determined by the shortest unstable
wavelength. Finally, we show that the oscillations of the inflaton field
amplify the inhomogeneities in the energy density, leading to local symmetry
restoration and faster thermalization. We believe this explains why tachyonic
preheating is so effective in transferring energy away from the inflaton zero
mode.Comment: 12 pages, 10 figures, REVTeX. Minor changes, some references added.
To appear in PR
3D heterotic string theory: new approach and extremal solutions
We develop a new formalism for the bosonic sector of low-energy heterotic
string theory toroidally compactified to three dimensions. This formalism is
based on the use of some single non-quadratic real matrix potential which
transforms linearly under the action of subgroup of the three-dimensional
charging symmetries. We formulate a new charging symmetry invariant approach
for the symmetry generation and straightforward construction of asymptotically
flat solutions. Finally, using the developed approach and the established
formal analogy between the heterotic and Einstein-Maxwell theories, we
construct a general class of the heterotic string theory extremal solutions of
the Israel-Wilson-Perjes type. This class is asymptotically flat and charging
symmetry complete; it includes the extremal solutions constructed before and
possesses the non-trivial bosonic string theory limit.Comment: 20 pages in Late
Tests of Higgs Boson Couplings at a mu+mu- Collider
We investigate the potential of a muon collider for testing the presence of
anomalous Higgs boson couplings. We consider the case of a light (less than
) Higgs boson and study the effects on the Higgs branching ratios and
total width, which could be induced by the non standard couplings created by a
class of dim=6 gauge invariant operators
satisfying the constraints imposed by the present and future hadronic and
colliders. For each operator we give the minimal value of the
integrated luminosity needed for the muon collider () to
improve these constraints. Depending on the operator and the Higgs mass, this
minimal luminosity lies between and .Comment: 18 pages and 4 figures; version to be published in Phys. Rev.D.
e-mail: [email protected]
Radiation Hydrodynamical Instabilities in Cosmological and Galactic Ionization Fronts
Ionization fronts, the sharp radiation fronts behind which H/He ionizing
photons from massive stars and galaxies propagate through space, were
ubiquitous in the universe from its earliest times. The cosmic dark ages ended
with the formation of the first primeval stars and galaxies a few hundred Myr
after the Big Bang. Numerical simulations suggest that stars in this era were
very massive, 25 - 500 solar masses, with H II regions of up to 30,000
light-years in diameter. We present three-dimensional radiation hydrodynamical
calculations that reveal that the I-fronts of the first stars and galaxies were
prone to violent instabilities, enhancing the escape of UV photons into the
early intergalactic medium (IGM) and forming clumpy media in which supernovae
later exploded. The enrichment of such clumps with metals by the first
supernovae may have led to the prompt formation of a second generation of
low-mass stars, profoundly transforming the nature of the first protogalaxies.
Cosmological radiation hydrodynamics is unique because ionizing photons coupled
strongly to both gas flows and primordial chemistry at early epochs,
introducing a hierarchy of disparate characteristic timescales whose relative
magnitudes can vary greatly throughout a given calculation. We describe the
adaptive multistep integration scheme we have developed for the self-consistent
transport of both cosmological and galactic ionization fronts.Comment: 6 pages, 4 figures, accepted for proceedings of HEDLA2010, Caltech,
March 15 - 18, 201
- …