27 research outputs found
Atom capture by nanotube and scaling anomaly
The existence of bound state of the polarizable neutral atom in the inverse
square potential created by the electric field of single walled charged carbon
nanotube (SWNT) is shown to be theoretically possible. The consideration of
inequivalent boundary conditions due to self-adjoint extensions lead to this
nontrivial bound state solution. It is also shown that the scaling anomaly is
responsible for the existence of bound state. Binding of the polarizable atoms
in the coupling constant interval \eta^2\in[0,1) may be responsible for the
smearing of the edge of steps in quantized conductance, which has not been
considered so far in literature.Comment: Accepted in Int.J.Theor.Phy
Laser-noise-induced correlations and anti-correlations in Electromagnetically Induced Transparency
High degrees of intensity correlation between two independent lasers were
observed after propagation through a rubidium vapor cell in which they generate
Electromagnetically Induced Transparency (EIT). As the optical field
intensities are increased, the correlation changes sign (becoming
anti-correlation). The experiment was performed in a room temperature rubidium
cell, using two diode lasers tuned to the Rb line (nm). The cross-correlation spectral function for the pump and probe fields
is numerically obtained by modeling the temporal dynamics of both field phases
as diffusing processes. We explored the dependence of the atomic response on
the atom-field Rabi frequencies, optical detuning and Doppler width. The
results show that resonant phase-noise to amplitude-noise conversion is at the
origin of the observed signal and the change in sign for the correlation
coefficient can be explained as a consequence of the competition between EIT
and Raman resonance processes.Comment: Accepted for publication in EPJ
Time of arrival through interacting environments: Tunneling processes
We discuss the propagation of wave packets through interacting environments.
Such environments generally modify the dispersion relation or shape of the wave
function. To study such effects in detail, we define the distribution function
P_{X}(T), which describes the arrival time T of a packet at a detector located
at point X. We calculate P_{X}(T) for wave packets traveling through a
tunneling barrier and find that our results actually explain recent
experiments. We compare our results with Nelson's stochastic interpretation of
quantum mechanics and resolve a paradox previously apparent in Nelson's
viewpoint about the tunneling time.Comment: Latex 19 pages, 11 eps figures, title modified, comments and
references added, final versio
MGMT gene silencing and benefit from temozolomide in glioblastoma.
BACKGROUND: Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents.
METHODS: We tested the relationship between MGMT silencing in the tumor and the survival of patients who were enrolled in a randomized trial comparing radiotherapy alone with radiotherapy combined with concomitant and adjuvant treatment with temozolomide. The methylation status of the MGMT promoter was determined by methylation-specific polymerase-chain-reaction analysis.
RESULTS: The MGMT promoter was methylated in 45 percent of 206 assessable cases. Irrespective of treatment, MGMT promoter methylation was an independent favorable prognostic factor (P<0.001 by the log-rank test; hazard ratio, 0.45; 95 percent confidence interval, 0.32 to 0.61). Among patients whose tumor contained a methylated MGMT promoter, a survival benefit was observed in patients treated with temozolomide and radiotherapy; their median survival was 21.7 months (95 percent confidence interval, 17.4 to 30.4), as compared with 15.3 months (95 percent confidence interval, 13.0 to 20.9) among those who were assigned to only radiotherapy (P=0.007 by the log-rank test). In the absence of methylation of the MGMT promoter, there was a smaller and statistically insignificant difference in survival between the treatment groups.
CONCLUSIONS: Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylated MGMT promoter did not have such a benefit
Quantum non-demolition (QND) modulation of quantum interference
We propose an experiment where quantum interference between two different
paths is modulated by means of a QND measurement on one or both the arm of the
interferometer. The QND measurement is achieved in a Kerr cell. We illustrate a
scheme for the realisation of this experiment and some further developments.Comment: accepted for publicatio
Machine learning in medical applications
Book synopsis: In recent years machine learning has made its way from artificial intelligence into areas of administration, commerce, and industry. Data mining is perhaps the most widely known demonstration of this migration, complemented by less publicized applications of machine learning like adaptive systems in industry, financial prediction, medical diagnosis and the construction of user profiles for Web browsers.
This book presents the capabilities of machine learning methods and ideas on how these methods could be used to solve real-world problems. The first ten chapters assess the current state of the art of machine learning, from symbolic concept learning and conceptual clustering to case-based reasoning, neural networks, and genetic algorithms. The second part introduces the reader to innovative applications of ML techniques in fields such as data mining, knowledge discovery, human language technology, user modeling, data analysis, discovery science, agent technology, finance, etc