Superficial geology and hydrogeological domains between Durham and Darlington. Phase 1, (Durham South)

The North East Region’s Groundwater Modelling Strategy has identified the need for the development of a conceptual model for the Magnesian Limestone aquifer. In line with the Environment Agency R&D Technical Report W214 (Environment Agency Framework for Groundwater Resources Conceptual and Numerical Modelling), a scoping study was produced, that identified areas of uncertainty and work required for the development of the conceptual model. The purpose of this project is to give the Environment Agency (EA) a regional understanding of the geology and hydrogeology of the Magnesian Limestone and overlying superficial deposits in the North East Region, using information presently held by the British Geological Survey (BGS). This report contributes to the conceptual model and understanding of the Magnesian Limestone aquifer. There is uncertainty in the amount of recharge that the Magnesian Limestone receives from rainfall. The project is designed to gain a greater understanding of the geology of the superficial deposits and their hydrogeological properties. These are the key factors for the calculation of recharge to the Magnesian Limestone aquifer from rainfall. This element of the conceptual model is essential in understanding the potential water resource available within this aquifer

Superficial geology and hydrogeological domains between Durham and Darlington. Phase 2, (Durham North)

The North East Region’s Groundwater Modelling Strategy has identified the need for the development of a conceptual model for the Magnesian Limestone aquifer. In line with the Environment Agency R&D Technical Report W214 (Environment Agency Framework for Groundwater Resources Conceptual and Numerical Modelling), a scoping study was produced, that identified areas of uncertainty and work required for the development of the conceptual model. The purpose of this project is to give the Environment Agency (EA) a regional understanding of the geology and hydrogeology of the Magnesian Limestone and overlying superficial deposits in the North East Region, using information held by the British Geological Survey (BGS). This report contributes to the conceptual model and understanding of the Magnesian Limestone aquifer. There is uncertainty in the amount of recharge that the Magnesian Limestone receives from rainfall. The project is designed to gain a greater understanding of the geology of the superficial deposits and their hydrogeological properties. These are the key factors for the calculation of recharge to the Magnesian Limestone aquifer from rainfall. This element of the conceptual model is essential in understanding the potential water resource available within this aquifer

Construction management and lean thinking in highways maintenance

To realize the benefits of BIM in construction management using (4D and 5D applications), it has to be implemented first. There are various BIM implementation plans to select from; with BIM features and guides, companies better understand BIM concepts and can easily choose a plan to apply in their operations. A literature review was conducted and 15 different definitions of BIM were encountered. Twelve different BIM implementation plans were found in publications by academics, software vendors and Architecture/Engineering/Construction (AEC) industry professionals. Those implementation plans were compared using a matrix which covers the complete building lifecycle. This research concludes that out of the 12 implementations plans, three were equipped with additional guides attached to their plans, simplifying project data collection; namely those by Autodesk, Penn State University and Indiana University. One implementation plan that scored very highly (based on 16 key issues identified from the three categories of stakeholders specified in this project) was the implementation plan proposed by a major software vendor. BIM is poised to solve many of the shortcomings reported in the construction industry. However, before realizing the full potential of BIM in construction management, it needs to be systematically implemented

Genetic determinants of cellular addiction to DNA polymerase theta

Polymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, referred to as Theta Mediated End Joining (TMEJ). Cells with homologous recombination deficiency are reliant on TMEJ for DSB repair. It is unknown whether deficiencies in other components of the DNA damage response (DDR) also result in Pol θ addiction. Here we use a CRISPR genetic screen to uncover 140 Polq synthetic lethal (PolqSL) genes, the majority of which were previously unknown. Functional analyses indicate that Pol θ/TMEJ addiction is associated with increased levels of replication-associated DSBs, regardless of the initial source of damage. We further demonstrate that approximately 30% of TCGA breast cancers have genetic alterations in PolqSL genes and exhibit genomic scars of Pol θ/TMEJ hyperactivity, thereby substantially expanding the subset of human cancers for which Pol θ inhibition represents a promising therapeutic strategy

Quality of life in post-surgical hypoparathyroidism (PoSH) in thyroid and parathyroid surgery

Background Post-surgical hypoparathyroidism (PoSH) is often long term, with significant associated morbidity and ongoing treatment. A recent systematic review found impaired quality of life (QoL) in patients with PoSH, despite stable treatment. Most studies did not include an appropriate control arm and further studies were recommended, taking into account underlying disease and comorbidities. This study aims to compare QoL in patients with PoSH with appropriate control groups. Methods This was a cross-sectional observational study using the general quality of life SF-36 tool and a hypocalcaemia symptom score (HcSS) to assess QoL in patients with PoSH and controls (who had similar surgery but without PoSH). Participants were identified from two patient groups (the Butterfly Thyroid Cancer Trust and the Association for Multiple Endocrine Neoplasia Disorders) and a single tertiary centre in the UK. Results Four hundred and thirty-nine responses (female n = 379, PoSH n = 89) were included with a median (range) age of 52 (19–92) years. Reported dates of surgery ranged from 1973 to 2019. HcSS scores showed significantly more associated symptoms in patients with PoSH than those without (p < 0.001). Although there was no overall difference in QoL between groups, patients with PoSH consistently had lower scores (p = 0.008) in the energy/fatigue subdomain of the SF-36. Conclusion Patients with PoSH reported significantly more fatigue and loss of energy compared to appropriately matched controls, but overall QoL was not significantly different. Standardised QoL measures may not be sensitive enough to highlight the impact on QoL in these patients. A disease-specific tool may be required

Ocean warming and acidification have complex interactive effects on the dynamics of a marine fungal disease

Diseases threaten the structure and function of marine ecosystems and are contributing to the global decline of coral reefs. We currently lack an understanding of how climate change stressors, such as ocean acidification (OA) and warming, may simultaneously affect coral reef disease dynamics, particularly diseases threatening key reef-building organisms, for example crustose coralline algae (CCA). Here, we use coralline fungal disease (CFD), a previously described CCA disease from the Pacific, to examine these simultaneous effects using both field observations and experimental manipulations. We identify the associated fungus as belonging to the subphylum Ustilaginomycetes and show linear lesion expansion rates on individual hosts can reach 6.5 mm per day. Further, we demonstrate for the first time, to our knowledge, that ocean-warming events could increase the frequency of CFD outbreaks on coral reefs, but that OA-induced lowering of pH may ameliorate outbreaks by slowing lesion expansion rates on individual hosts. Lowered pH may still reduce overall host survivorship, however, by reducing calcification and facilitating fungal bio-erosion. Such complex, interactive effects between simultaneous extrinsic environmental stressors on disease dynamics are important to consider if we are to accurately predict the response of coral reef communities to future climate change

Geology of the Abu Dhabi 1:100 000 map sheet, 100-16, United Arab Emirates

This Sheet Description describes the Quaternary and solid geology of the Abu Dhabi 1:100 000 scale geological map. The Abu Dhabi district covers 3620 km2 along the Arabian Gulf coast including the northern part of Saadiyat island, Abu Dhabi, part of the Mussafah district and many of the islands to the west. These include Futaisi, Bu Kesheishah, Halat al Bharaini, Al Dabiya, Bu Qumah, Bu Shara, Al Qanatir and Al Rafiq. The sheet also includes a significant part of the coastal plain southwest of Abu Dhabi between Shunayyin in the east to Borquat al Rashid in the west, and south to Maharqah, across which the main E11 coastal highway runs. In the southeast of the district, an area of higher ground is formed of Miocene rocks draped by a variable sequence of cemented and unconsolidated dune sand. The region hosts several major oilfields including the Rumaitha, Shanayel, Al Dabb’iya, Umm al Dalkh, Al Mutarib and Umm al Lulu fields. The region is dominated by a series of offshore islands, part of a chain of barrier islands that extend from north of Abu Dhabi to Marawah Island, west of the present area. These islands, along with the sea-ward margin of the coastal plain are mostly comprised of a thin sequence of intensively studied Holocene marine carbonates termed the Abu Dhabi Formation. These sediments represent a transgressive-regressive sequence, and form the classic carbonate-evaporitic ‘sabkhas’ for which the region is justly famous. The Abu Dhabi Formation includes a range of marine and supratidal facies including coastal spits, bars and beach ridges, lagoonal muds, algal mats and ooidal tidal deltas deposited over the last 10 000 years. The southern limit of the Holocene transgression is marked by a beach ridge running parallel to the coast and clearly visible on satellite imagery. The barrier islands commonly have a core of well-cemented Pleistocene carbonate dune sand (Ghayathi Formation) around which the carbonate spits, bars and ridges of the Abu Dhabi Formation were accreted. The islands have been largely deflated down to the local water-table leading to the development of extensive sabkhas. Consequently, the islands are generally flat but punctuated by small Ghayathi Formation mesas and zeugen, forming mushroom-shaped outcrops rising up to 6 m above sea-level, locally capped with marine limestones of the Late Pleistocene Fuwayrit Formation. Offshore to the north of the island, below low water, is the Great Pearl Bank, an area of reefs and coralgal sands named after the former pearling industry in the region. South of the Holocene beach ridge, much of the onshore area is an extensive, very gently sloping coastal plain, dominated by a deflated planation surface developed on either unconsolidated quartzose aeolian sand or well cemented carbonate grainstones of the Ghayathi Formation. The deflation surface is commonly marked by secondary gypsum forming a sabkha. The Ghayathi Formation palaeodunes are locally well exposed, forming spectacular wind-sculpted mesas and zeugen both on the islands and within the lagoons, but also onshore draping the Miocene rocks in the southeast of the district

The purified extract from the medicinal plant Bacopa monnieri, bacopaside II, inhibits growth of colon cancer cells in vitro by inducing cell cycle arrest and apoptosis

Published: 21 July 2018Aquaporin-1 (AQP1), a transmembrane pore-forming molecule, facilitates the rapid movement of water and small solutes across cell membranes. We have previously shown that bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the AQP1 water channel and impairs migration of cells that express AQP1. The aim of this study was to further elucidate the anti-tumour potential of bacopaside II in colon cancer cells. Expression of AQP1 in HT-29, SW480, SW620 and HCT116 was determined by quantitative PCR and western immunoblot. Cells were treated with bacopaside II, and morphology, growth, autophagy, cell cycle and apoptosis assessed by time-lapse microscopy, crystal violet, acridine orange, propidium iodide (PI) and annexin V/PI staining respectively. AQP1 expression was significantly higher in HT-29 than SW480, SW620 and HCT116. Bacopaside II significantly reduced growth at ≥20 µM for HT-29 and ≥15 µM for SW480, SW620 and HCT116. Inhibition of HT-29 at 20 µM was primarily mediated by G0/G1 cell cycle arrest, and at 30 µM by G2/M arrest and apoptosis. Inhibition of SW480, SW620 and HCT116 at ≥15 µM was mediated by G2/M arrest and apoptosis. These results are the first to show that bacopaside II inhibits colon cancer cell growth by inducing cell cycle arrest and apoptosis.Eric Smith, Helen M. Palethorpe, Yoko Tomita, Jinxin V. Pei, Amanda R. Townsend, Timothy J. Price, Joanne P. Young, Andrea J. Yool and Jennifer E. Hardingha

N-body simulations of gravitational dynamics

We describe the astrophysical and numerical basis of N-body simulations, both of collisional stellar systems (dense star clusters and galactic centres) and collisionless stellar dynamics (galaxies and large-scale structure). We explain and discuss the state-of-the-art algorithms used for these quite different regimes, attempt to give a fair critique, and point out possible directions of future improvement and development. We briefly touch upon the history of N-body simulations and their most important results.Comment: invited review (28 pages), to appear in European Physics Journal Plu

The Intentional Use of Service Recovery Strategies to Influence Consumer Emotion, Cognition and Behaviour

Service recovery strategies have been identified as a critical factor in the success of. service organizations. This study develops a conceptual frame work to investigate how specific service recovery strategies influence the emotional, cognitive and negative behavioural responses of . consumers., as well as how emotion and cognition influence negative behavior. Understanding the impact of specific service recovery strategies will allow service providers' to more deliberately and intentionally engage in strategies that result in positive organizational outcomes. This study was conducted using a 2 x 2 between-subjects quasi-experimental design. The results suggest that service recovery has a significant impact on emotion, cognition and negative behavior. Similarly, satisfaction, negative emotion and positive emotion all influence negative behavior but distributive justice has no effect