57 research outputs found
Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease
Background: Insulin-like growth factor (IGF)-1 has been implicated in the pathogenesis of Alzheimer's disease ( AD).
Methods: We compared the level of circulating total and bioavailable IGF-1, by simultaneous measurements of IGF-1 and IGF binding protein ( IGFBP)-3, between 87 patients diagnosed with AD and 126 age and sex matched control subjects without cognitive impairment. Blood samples were collected and IGF-1 and IGFBP-3 measured by ELISA. Subjects were also genotyped for apolipoprotein E.
Results: Total circulating IGF-1 levels were significantly raised in the AD group as compared to the control group (p = 0.022). There was no significant difference in the circulating level of IGFBP-3 between the two groups. When the IGF-1 levels were ratioed against IGFBP-3 levels as an indicator of unbound, bioavailable circulating IGF-1, there was a significant increase in the molar IGF-1:IGFBP-3 ratio in the AD subjects (0.181 +/- 0.006) as compared to the controls (0.156 +/- 0.004) (p < 0.001). Logistic regression analysis revealed that an increase in the IGF-1: IGFBP-3 molar ratio increased the risk of AD significantly.
Conclusion: The results of increased total and free circulating IGF-1 support the hypothesis that in its early stages late-onset AD reflects a state of resistance to IGF-1
Effects of the parasitism of Struthanthus flexicaulis (Mart.) Mart. (Loranthaceae) on the fitness of Mimosa calodendron Mart. (Fabaceae), an endemic shrub from rupestrian fields over ironstone outcrops, Minas Gerais State, Brazil
Rosaramicin and tetracycline in the treatment of non-gonococcal urethritis. A comparison of clinical and microbiological results.
Chlamydial infection in homosexual men. Frequency of isolation of Chlamydia trachomatis from the urethra, ano-rectum, and pharynx.
Chlamydia trachomatis and Ureaplasma urealyticum in men attending a sexually transmitted diseases clinic.
Comparison of tetracycline and minocycline in the treatment of non-gonococcal urethritis.
An association between non-gonococcal urethritis and bacterial vaginosis and the implications for patients and their sexual partners.
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