Metallo-dielectric diamond and zinc-blende photonic crystals

It is shown that small inclusions of a low absorbing metal can have a dramatic effect on the photonic band structure. In the case of diamond and zinc-blende photonic crystals, several complete photonic band gaps (CPBG's) can open in the spectrum, between the 2nd-3rd, 5th-6th, and 8th-9th bands. Unlike in the purely dielectric case, in the presence of small inclusions of a low absorbing metal the largest CPBG for a moderate dielectric constant (epsilon<=10) turns out to be the 2nd-3rd CPBG. The 2nd-3rd CPBG is the most important CPBG, because it is the most stable against disorder. For a diamond and zinc-blende structure of nonoverlapping dielectric and metallo-dielectric spheres, a CPBG begins to decrease with an increasing dielectric contrast roughly at the point where another CPBG starts to open--a kind of gap competition. A CPBG can even shrink to zero when the dielectric contrast increases further. Metal inclusions have the biggest effect for the dielectric constant 2<=epsilon<=12, which is a typical dielectric constant at near infrared and in the visible for many materials, including semiconductors and polymers. It is shown that one can create a sizeable and robust 2nd-3rd CPBG at near infrared and visible wavelengths even for a photonic crystal which is composed of more than 97% low refractive index materials (n<=1.45, i.e., that of silica glass or a polymer). These findings open the door for any semiconductor and polymer material to be used as genuine building blocks for the creation of photonic crystals with a CPBG and significantly increase the possibilities for experimentalists to realize a sizeable and robust CPBG in the near infrared and in the visible. One possibility is a construction method using optical tweezers, which is analyzed here.Comment: 25 pp, 23 figs, RevTex, to appear in Phys Rev B. For more information look at http://www.amolf.nl/research/photonic_materials_theory/moroz/moroz.htm

Multimodal prehabilitation to reduce the incidence of delirium and other adverse events in elderly patients undergoing elective major abdominal surgery: An uncontrolled before-and-after study

Background Delirium is a common and serious complication in elderly patients undergoing major abdominal surgery, with significant adverse outcomes. Successful strategies or therapies to reduce the incidence of delirium are scarce. The objective of this study was to assess the role of prehabilitation in reducing the incidence of delirium in elderly patients. Methods A single-center uncontrolled before-and-after study was conducted, including patients aged 70 years or older who underwent elective abdominal surgery for colorectal carcinoma or an abdominal aortic aneurysm between January 2013 and

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications

Combined strain gradient and concrete strength effects on flexural strength and ductility design of RC columns

The stress-strain relationship of concrete in flexure is one of the essential parameters in assessing the flexural strength and ductility of reinforced concrete (RC) columns. An overview of previous research studies revealed that the presence of strain gradient would affect the maximum concrete stress developed in flexure. However, no quantitative model was available to evaluate the strain gradient effect on concrete under flexure. Previously, the authors have conducted experimental studies to investigate the strain gradient effect on maximum concrete stress and respective strain and developed two strain-gradient-dependent factors k3 and ko for modifying the flexural concrete stress-strain curve. As a continued study, the authors herein will extend the investigation of strain gradient effects on flexural strength and ductility of RC columns to concrete strength up to 100 MPa by employing the strain-gradient-dependent concrete stress-strain curve using nonlinear moment-curvature analysis. It was evident from the results that both the flexural strength and ductility of RC columns are improved under strain gradient effect. Lastly, for practical engineering design purpose, a new equivalent rectangular concrete stress block incorporating the combined effects of strain gradient and concrete strength was proposed and validated. Design formulas and charts have also been presented for flexural strength and ductility of RC columns

An analysis-based model for axially loaded circular CFST columns

Concrete-filled-steel-tube (CFST) columns have been increasingly adopted in many modern structures due to the beneficial composite action between steel tube and core concrete. Previous experimental and theoretical studies have proved this composite action can be further improved by providing external confinement in the form of steel rings, tie bars, spirals or jackets. A theoretical model developed by the authors previously based on (1) an accurate hoop strain equation; (2) an actively confined concrete model; (3) a three-dimensional steel model; (4) Interaction of core concrete, steel tube and external confinement was adopted in this paper to conduct a parametric study, which aims at investigating the effects of steel tube yield strength, concrete compressive strength, steel ratio and external confinement on the uni-axial behaviour of CFST columns. From the results in parametric study, two sets of critical steel ratios based on two different levels of ductility at different steel yield and concrete compressive strengths have been obtained. In addition, the maximum column strength obtained from the model and previous experimental studies was compared with the design strength calculated using different design codes. New design equations that can predict the axial strength more satisfactorily have also been proposed